Bromine Deficiency and Insomnia in Patients on Dialysis

Oe, Pridatko; Vis, Roeland; Meijer, Janne‐Mieke; Langevelde, F. Van; V., Allon, W. M. er, C.; Verheul, Henk M.W.

doi:10.1007/978-3-642-68269-8_133

Cited by 7 publications

(5 citation statements)

References 2 publications

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“…Patients receiving total parenteral nutrition (TPN) are reported to have low plasma Br − levels due to lower dietary Br consumption (Dahlstrom et al, 1986), and end-stage renal disease patients have enhanced Br − losses as a consequence of dialysis (Miura et al, 2002; Oe et al, 1981; Wallaeys et al, 1986). Since Br has not been considered an essential trace element, systematic investigations on Br − replacement have not been pursued in these disease states.…”

Section: Discussionmentioning

confidence: 99%

Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture

McCall

Cummings

Bhave

et al. 2014

Cell

324

275

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Summary Bromine is ubiquitously present in animals as ionic bromide (Br−) yet has no known essential function. Herein, we demonstrate that Br− is a required cofactor for peroxidasin-catalyzed formation of sulfilimine crosslinks, a post-translational modification essential for tissue development and architecture found within the collagen IV scaffold of basement membranes (BMs). Bromide, converted to hypobromous acid, forms a bromosulfonium-ion intermediate that energetically selects for sulfilimine formation. Dietary Br-deficiency is lethal in Drosophila while Br-replenishment restores viability, demonstrating its physiologic requirement. Importantly, Br-deficient flies phenocopy the developmental and BM defects observed in peroxidasin mutants and indicate a functional connection between Br−, collagen IV, and peroxidasin. We establish that Br− is required for sulfilimine formation within collagen IV, an event critical for BM assembly and tissue development. Thus, bromine is an essential trace element for all animals and its deficiency may be relevant to BM alterations observed in nutritional and smoking related disease.

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Section: Discussionmentioning

confidence: 99%

Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture

McCall

Cummings

Bhave

et al. 2014

Cell

324

275

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show abstract

“…Interestingly, the possible association between bromine deficiency and insomnia in hemodialysis patients was suggested more than 40 years ago, but later seems to have been forgotten [ 54 ]. Many years later (in 2006), Canavese et al [ 55 ] raised the question again, noting that bromine is associated with brain metabolism, is used as a sedative to induce sleep, and increases in animals during hibernation as well as in sleeping humans, further highlighting the discovery of a bromine compound with REM-sleep-inducing and anti-cholinesterase activities that was isolated from human cerebrospinal fluid and identified as 1-methylheptyl gamma-bromoacetoacetate The authors concluded with a strong suggestion “that further studies address the evaluation of bromine status in dialysis patients”, which was what we intended in this study.…”

Section: Discussionmentioning

confidence: 99%

Serum Iodine and Bromine in Chronic Hemodialysis Patients—An Observational Study in a Cohort of Portuguese Patients

Novakova

Bonev

Duro

et al. 2023

Toxics

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Background: Patients on chronic hemodialysis therapy are at high risk of disturbances in trace element status due to both the underlying disease and the hemodialysis process itself. Data on iodine and bromine levels in these patients are scarce. Methods: Using an ICP-MS analytical procedure, serum iodine and bromine levels were determined in a cohort (n = 57) of end-stage renal disease patients on chronic hemodialysis. The results were compared with those of a control group (n = 59). Results: Hemodialysis patients presented serum iodine levels within the normal range, slightly lower than in controls, but without reaching a statistically significant difference (67.6 ± 17.1 µg/L vs. 72.2 ± 14.8 µg/L; p = 0.1252). In contrast, serum bromine levels were much lower in patients (1086 ± 244 µg/L vs. 4137 ± 770 µg/L; p < 0.0001), at values only about 26% of the values observed in controls. Conclusions: Hemodialysis patients had normal serum iodine levels, but highly decreased serum bromine levels. The clinical significance of this finding requires further investigation, but it may be associated with sleep disturbances and fatigue that affect hemodialysis patients.

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“…In contrast, Br levels in both serum and packed blood cells are far below normal values in both hemodialysis (15,17) and peritoneal dialysis patients (18). Br is readily removed by both HD and CAPD.…”

Section: Brominementioning

confidence: 94%

“…Br is readily removed by both HD and CAPD. Subnormal blood levels of Br have been hypothetically related as a cause for insomnia of dialysis patients (17).…”

Section: Brominementioning

confidence: 99%

Does Abnormal Trace Element Metabolism Contribute to Dialysis Patient Morbidity? Opinion

Lameire¹,

Cornelis²,

Vanholder³

1999

Seminars in Dialysis

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Bromine Deficiency and Insomnia in Patients on Dialysis

Cited by 7 publications

References 2 publications

Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture

Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture

Serum Iodine and Bromine in Chronic Hemodialysis Patients—An Observational Study in a Cohort of Portuguese Patients

Does Abnormal Trace Element Metabolism Contribute to Dialysis Patient Morbidity? Opinion

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