Bromine in blood, EEG and transaminases in methyl bromide workers.

Verberk, Maarten M.; Rooyakkers-beemster, T.; Vlieger, M. de; Vliet, A. G. M. van

doi:10.1136/oem.36.1.59

Cited by 15 publications

(8 citation statements)

References 4 publications

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“…Currently, there are no reliable biomarkers to assess human exposure to fumigants in epidemiologic studies (Hustinx et al, 1993; Magnavita, 2009; Verberk et al, 1979). Thus, residential proximity to fumigant use is currently the best method to characterize potential exposure.…”

Section: Introductionmentioning

confidence: 99%

Residential proximity to agricultural fumigant use and IQ, attention and hyperactivity in 7-year old children

Gunier

Bradman

Castorina

et al. 2017

Environmental Research

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Objectives Our objective was to examine the relationship between residential proximity to agricultural fumigant use and neurodevelopment in 7-year old children. Methods Participants were living in the agricultural Salinas Valley, California and enrolled in the Center for the Health Assessment of Mothers and Children Of Salinas (CHAMACOS) study. We administered the Wechsler Intelligence Scale for Children (4th Edition) to assess cognition and the Behavioral Assessment System for Children (2nd Edition) to assess behavior. We estimated agricultural fumigant use within 3, 5 and 8 km of residences during pregnancy and from birth to age 7 using California’s Pesticide Use Report data. We evaluated the association between prenatal (n=285) and postnatal (n=255) residential proximity to agricultural use of methyl bromide, chloropicrin, metam sodium and 1,3-dichloropropene with neurodevelopment. Results We observed decreases of 2.6 points (95% Confidence Interval (CI): −5.2, 0.0) and 2.4 points (95% CI: −4.7, −0.2) in Full-Scale intelligence quotient for each ten-fold increase in methyl bromide and chloropicrin use within 8 km of the child’s residences from birth to 7-years of age, respectively. There were no associations between residential proximity to use of other fumigants and cognition or proximity to use of any fumigant and hyperactivity or attention problems. These findings should be explored in larger studies.

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Section: Introductionmentioning

confidence: 99%

Residential proximity to agricultural fumigant use and IQ, attention and hyperactivity in 7-year old children

Gunier

Bradman

Castorina

et al. 2017

Environmental Research

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“…However, no new insights are available for the derivation of a threshold limit value. The BLW is therefore still based on the investigations by Verberk et al (1979) (see BAT Documentation 2002, translated). This study describes the abnormalities in the EEG of workers exposed to methyl bromide in relation to their blood bromide concentrations.…”

Section: Discussionmentioning

confidence: 99%

Addendum to Methyl bromide [BAT Value Documentation 2014]

Hallier

Müller

Drexler

et al. 2017

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the BLW (“Biologischer Leitwert”) for methyl bromide, using bromide in serum/plasma to characterise the internal exposure. The critical effect of methyl bromide is a high acute and chronic neurotoxicity. It can pass through the skin so that biological monitoring is highly recommended. On the basis of results of a human study the occurrence of abnormal findings in the EEG is comparable for unexposed persons and persons with exposure to methyl bromide in concentrations below 12 mg bromide/l plasma. Thus the BLW of 12 mg bromide/l plasma or serum was confirmed. The sampling time for long‐term exposure is at the end of exposure/shift after several previous shifts. The evaluation of an EKA for methyl bromide in the air and S‐methylcysteine‐albumin adducts in blood is not possible as there is insufficient data available.

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“…The levels of bromine found in the present study are within the lower range of those relating to EEG abnormalities in methyl-bromide workers in the earliest stages of bromine intoxication. Verberk et a! (1979) found a geometric mean whole-blood bromine level of l0.9@ig/ml (meanÂ±s.d.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study we, therefore, assessed whether the bromine levels of lithium patients were raised, and if so whether they related to response to lithium treatment. Slightly raised levels of bromine in blood in workers using methyl bromide as a pesticide have been shown to produce electroencephalographic (EEG) abnormalities (Verberk et al, 1979). It is well known that long-term lithium treatment produces EEG abnormalities in some patients, although it is impossible to predict those in whom they will occur.…”

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confidence: 99%

Trace Elements and the Electroencephalogram During Long-term Lithium Treatment

1992

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Endogenous bromine has been found to be raised during lithium treatment, and it has been suggested that it may augment the therapeutic effect of lithium. Our findings in a study of 12 patients and 12 controls support this contention. Electroencephalographic effects of bromine, vanadium and aluminium were studied--higher bromine and vanadium levels were associated with irregular cortical activity. Electroencephalographic abnormalities were associated with more side-effects of lithium.

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Bromine in blood, EEG and transaminases in methyl bromide workers.

Cited by 15 publications

References 4 publications

Residential proximity to agricultural fumigant use and IQ, attention and hyperactivity in 7-year old children

Residential proximity to agricultural fumigant use and IQ, attention and hyperactivity in 7-year old children

Addendum to Methyl bromide [BAT Value Documentation 2014]

Trace Elements and the Electroencephalogram During Long-term Lithium Treatment

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