Bromonitromethane

Resolving Bromonitromethane Sourcing by Synthesis: Preparation at the Decagram Scale

“…Bromonitromethane is a versatile reagent used in the preparation of nitroheterocycles, nitrocyclopropanes, α-functionalized terminal nitroalkanes and, to a limited extent, 1,3-dipolar cycloaddition products . Advances in the synthesis of enantiopure amines, amides, and peptides have increasingly relied on the reagent, , which was commercially available at a reasonable cost for many years. More recently, our work leveraging bromonitromethane as a reagent was stymied by the need to contract with a supplier for amounts both smaller and more expensive (ranging USD from $0.48 to >$6 per millimole) than those previously available.…”