Bromophycolide A Targets Heme Crystallization in the Human Malaria Parasite Plasmodium falciparum

Bromophycoic Acids: Bioactive Natural Products from a Fijian Red Alga Callophycus sp.

“…3 Bromophycoic acid C ( 3 ), with modest activity against MRSA, was most active among bromophycoic acids and callophycoic acids against the malaria parasite P. falciparum with an IC 50 of 8.7 μM. Compared with macrocyclic bromphycolide A (IC 50 = 0.5 μM), 17 however, this activity is modest. Nevertheless, it is the first among non-macrocyclic benzoic acid-diterpene metabolites to show appreciable activity against a protozoan parasite.…”

The Hybrid Pyrroloisoindolone–Dehydropyrrolizine Alkaloid (−)‐Chlorizidine A Targets Proteins within the Glycolytic Pathway

“…Using a carbodiimide coupling (Scheme 2), a mono -labeled probe 8 was prepared by esterification of 1 with acid 6 . [9] NMR analysis indicated that while probe 8 was pure (purity was also confirmed via LC/MS and HPLC analyses), it was likely a mixture of the C6 and C8 isomers (Supporting Information). We have previously observed a similar lack of selectivity in labeling polyphenolic natural products.…”

Fluorescent kapakahines serve as non-toxic probes for live cell Golgi imaging

“…Our studies began by applying our recently developed immunoaffinity fluorescent (IAF) system to prepare active kapakahine probes (Kumar et al, 2011;Yu et al, 2012;Stout et al, 2011;Yu et al, 2011, Hughes et al, 2009. We installed an IAF tag containing a fluorescent 7-(dimethylamino)coumarin-4-acetic acid reporter at the amino group of the tryptophan residue.…”