Bromotheoynic acid, a brominated acetylenic acid from the marine sponge<i>Theonella swinhoei</i>

Aoki, Nobuwa; Yamamoto, Kazuhiro; Ogawa, Takayuki; Ohta, Emi; Ikeuchi, Toshitaka; Kamemura, Kazuo; Ikegami, Susumu; Ohta, Shigeru

doi:10.1080/14786419.2012.660636

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…610 Bromoacetylene testafuran A 573 was isolated from Xestospongia testudinaria (Iwo Is., Kagoshima, Japan) along with four other polyacetylenes 574-577, all ve of which induced apidogenesis (stimulation of the differentiation of preadipocytes to adipocytes), and hence may act as leads for treatment of cardiovascular disorders. 611 An inhibitor of starsh egg maturation, bromotheoynic acid 578, was reported from Theonella swinhoei (Tanegashima, Kagoshima, Japan), 612 while two further bromopolyacetylenes 579 and 580 were obtained from Haliclona sp. (Sharm Obhur, Jeddah, Saudi Arabia).…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2015

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This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2015

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“…A collection of the sponge Theonella swinhoei from Japanese waters (Tanegashima, Kagoshima Prefecture) has provided bromotheoynic acid ( 341 ) ( Figure 67 ) [ 134 ]. This new brominated C 17 acetylenic acid inhibits the cell proliferation of U937 and HL60 (human leukemia), A549 and H1299 (human lung), and HEK293 (human embryonic kidney) with values of IC 50 24, 27, 58, 72, and 40 mg/mL, respectively.…”

Section: Antitumor Compoundsmentioning

confidence: 99%

Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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“…Sponges are a prolific source of specialized metabolites including rare fatty acid derivatives such as brominated acetylenic acids (Pham et al 1999;Aoki et al 2013;Ohta et al 2013;Dembitsky et al 2003). Several brominated fatty acids were described from Haliclona sponges (Alarif Walied et al 2013;Aratake et al 2009) including renierins from H. fulva (Cimino and De Stefano 1977).…”

Section: Discussionmentioning

confidence: 99%

Metabolome variability for two Mediterranean sponge species of the genus Haliclona: specificity, time, and space

et al. 2018

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In this study, the intraspecific (temporal and spatial) variability of two Mediterranean Haliclona sponges (H. fulva and H. mucosa) was investigated through an untargeted and then targeted metabolomics approach and further compared to their interspecific variability. Methods Samples of both species were collected monthly during 1 year in the coralligenous habitat of the Northwestern Mediterranean sae at Marseille and Nice. Their metabolomic profiles were obtained by UHPLC-QqToF analyses. Results Marked variations were noticed in April and May for both species including a decrease in Shannon's diversity and concentration in specialized metabolites together with an increase in fatty acids and lyso-PAF like molecules. Spatial variations across different sampling sites could also be observed for both species, however in a lesser extent. Conclusions Synchronous metabolic changes possibly triggered by physiological factors like reproduction and/or environmental factors like an increase in the water temperature were highlighted for both Mediterranean Haliclona species inhabiting close habitats but displaying different biosynthetic pathways. Despite significative intraspecific variations, metabolomic variability remains minor when compared to interspecific variations for these congenerous species, therefore suggesting the predominance of genetic information of the holobiont in the observed metabolome.

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Bromotheoynic acid, a brominated acetylenic acid from the marine spongeTheonella swinhoei

Cited by 6 publications

References 19 publications

Marine natural products

Marine natural products

Biological Activity of Recently Discovered Halogenated Marine Natural Products

Metabolome variability for two Mediterranean sponge species of the genus Haliclona: specificity, time, and space

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