Bronchial Epithelial Alterations and Pulmonary Neoplasia Induced by Ozone

Werthamer, Seymour; Schwarz, Lewis H.; Soskind, Leo

doi:10.1159/000162234

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…However, its long-term toxicity and carcinogenic potential in rodents remains poorly defined. Several early studies suggested that ozone may be carcinogenic in the lungs of experimental animals (17,32,51). More recent studies seemingly confirm the earlier reported carcinogenic effect in certain mouse strains.…”

Section: Introductionmentioning

confidence: 55%

Two-Year and Lifetime Toxicity and Carcinogenicity Studies of Ozone in B6C3F1 Mice

et al. 1996

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To evaluate the toxicity and carcinogenic potential of long-term exposure to ozone, B6C3F1 mice were exposed by whole-body inhalation to 0, 0.12, 0.5, or 1.0 ppm and 0, 0.5, or 1.0 ppm ozone for 24 or 30 mo (lifetime), respectively. The incidence of alveolar/ bronchiolar adenomas and carcinomas (combined) increased (p < 0.05) in female mice exposed to 1.0 ppm for 24 or 30 mo and marginally increased (p > 0.05) in male mice exposed to concentrations of 0.5 or 1.0 ppm. An increased incidence of nonneoplastic lesions were observed in the nasal cavities and in the centriacinar region of the lung of mice exposed to 0.5 or 1.0 ppm for 24 and 30 mo. Nasal cavity lesions were mild and included hyaline degeneration, hyperplasia, squamous metaplasia, fibrosis and suppurative inflammation of the transitional and respiratory epithelium of the lateral wall, and atrophy of the olfactory epithelium. Lung lesions included replacement of the epithelium of the alveolar ducts and adjacent alveolar septa with epithelium similar to that normally found in terminal bronchioles (metaplasia) and associated alveolar histiocytosis. Based on the results of these studies, we conclude that inhalation exposure of B6C3F1 mice to ozone for 24 or 30 mo (a) is carcinogenic in female B6C3F1 mice exposed to 1.0 ppm of ozone based on an increased incidence of alveolar/bronchiolar adenoma or carcinoma and (b) results in mild, site-specific, nonneoplastic lesions in the nasal cavity and centriacinar lung of male and female mice exposed to 0.5 or 1.0 ppm of ozone for 2 yrs, which persist with continued exposure to 30 mo. It is uncertain whether or not the marginal increase (p > 0.05) of alveolar/bronchiolar neoplasms in male B6C3F1 mice resulted from exposure to ozone.

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Section: Introductionmentioning

confidence: 55%

Two-Year and Lifetime Toxicity and Carcinogenicity Studies of Ozone in B6C3F1 Mice

et al. 1996

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Respiratory symptoms of flight attendants during high-altitude flight: Possible relation to cabin ozone exposure

Tashkin¹,

Coulson

Simmons³

et al. 1983

Int. Arch Occup Environ Heath

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The smaller size and lighter weight of the Boeing 747SP aircraft, introduced into passenger service in 1976, permitted higher-altitude flight than older commercial aircraft and thus potentially greater ozone exposure for those of board. Concerned flight attendants distributed questionnaires relating to symptoms experienced on the Boeing 747SP and/or conventional 747 aircraft to Los Angeles- and New York-based flight attendants. Respondents reported symptoms by frequency and severity and by in-flight and after-flight occurrence. Based on the assessment of three health scientists as to ozone-relatedness, the frequency of "definite" and "probable" ozone-related symptoms of any severity reported by both groups of attendants was significantly associated with 747SP flights (chi-squares: P less than 0.05). After-flight symptoms significantly associated with 747SP experience, although fewer in number than in-flight symptoms, were all in the scientists' "definite" category. In 21 flight attendants who complained of moderate to severe symptoms during 747SP flights, a battery of pulmonary function tests performed approximately two weeks after their last 747SP flight failed to reveal abnormalities. The symptom questionnaire results are consistent with possible exposure of cabin attendants to toxic levels of ozone during the higher-altitude flights of the Boeing 747SP compared to conventional 747 aircraft.

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The Use of the single cell gel electrophoresis assay in detecting DNAsingle strand breaks in lung cells in vitro

Lee

Madden

Reed

et al. 1996

Toxicology and Applied Pharmacology

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Bronchial Epithelial Alterations and Pulmonary Neoplasia Induced by Ozone

Cited by 4 publications

References 10 publications

Two-Year and Lifetime Toxicity and Carcinogenicity Studies of Ozone in B6C3F1 Mice

Two-Year and Lifetime Toxicity and Carcinogenicity Studies of Ozone in B6C3F1 Mice

Respiratory symptoms of flight attendants during high-altitude flight: Possible relation to cabin ozone exposure

The Use of the single cell gel electrophoresis assay in detecting DNAsingle strand breaks in lung cells in vitro

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