Bronchial Hyperreactivity to Methacholine in Atopic Versus Nonatopic Asthmatic Schoolchildren and Preschoolers

Castro-Rodriguez, José A.; Navarrete-Contreras, Pamela; Holmgren, Linus; Sánchez, Ignacio; Caussade, Solange

doi:10.3109/02770903.2010.504875

Cited by 11 publications

(7 citation statements)

References 33 publications

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“…Therefore, a significant difference in BHR in the general population might be reflected in studies on asthmatic patients. Indeed, in the aforementioned studies, the frequency of using controller medications was higher in atopic than in non-atopic groups,38 and the prevalence of positive BHR was lower (atopic, 78%; non-atopic, 48.5%) 39. In another study, asymptomatic patients thought to be asthmatic also showed a lower prevalence of BHR (atopic, 41/81 vs. non-atopic, 7/37), which suggests that not all of the subjects were in fact asthmatic patients 44.…”

Section: Bhr In Subjects With Atopic or Non-atopic Asthmamentioning

confidence: 89%

“…In a study on 214 ten-year-old current wheezers (113 atopic, 101 non-atopic), the prevalence of subjects who had a methacholine PC20 of <4 mg/mL was higher in atopic than in non-atopic asthmatics 38. A recent study on 136 school-aged asthmatics also reported a higher prevalence of BHR to methacholine and a lower PC20 in atopic asthmatics than in non-atopic asthmatics 39. In contrast, in one study, the prevalence of BHR to methacholine in adult asthmatics was not different between atopic and non-atopic groups 40.…”

Section: Bhr In Subjects With Atopic or Non-atopic Asthmamentioning

confidence: 96%

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Relationship Between Atopy and Bronchial Hyperresponsiveness

Suh

Koh

2013

Allergy Asthma Immunol Res

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Both atopy and bronchial hyperresponsiveness (BHR) are characteristic features of asthma. They are also found among non-asthmatic subjects, including allergic rhinitis patients and the general population. Atopy and BHR in asthma are closely related. Atopy induces airway inflammation as an IgE response to a specific allergen, which causes or amplifies BHR. Moreover, significant evidence of the close relationship between atopy and BHR has been found in non-asthmatic subjects. In this article, we discuss the relationship between atopy and BHR in the general population, asthmatic subjects, and those with allergic rhinitis. This should widen our understanding of the pathophysiology of atopy and BHR.

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Section: Bhr In Subjects With Atopic or Non-atopic Asthmamentioning

confidence: 89%

Section: Bhr In Subjects With Atopic or Non-atopic Asthmamentioning

confidence: 96%

Relationship Between Atopy and Bronchial Hyperresponsiveness

Suh

Koh

2013

Allergy Asthma Immunol Res

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“…Several studies have reported that responsiveness to methacholine and AMP are indicators of BHR, but there are discrepancies in the reported prevalence rates of responsiveness to these tests in patients with atopic and non-atopic asthma 5,14. However, a recent study of 93 children with recurrent wheezing reported similar BHR to methacholine in children with atopic and non-atopic disease 6.…”

Section: Discussionmentioning

confidence: 99%

Bronchial Hyperresponsiveness to Methacholine and AMP in Children With Atopic Asthma

Kang

Kim

Seo

et al. 2012

Allergy Asthma Immunol Res

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PurposeBronchial hyperresponsiveness (BHR) is typically measured by bronchial challenge tests that employ direct stimulation by methacholine or indirect stimulation by adenosine 5'-monophosphate (AMP). Some studies have shown that the AMP challenge test provides a better reflection of airway inflammation, but few studies have examined the relationship between the AMP and methacholine challenge tests in children with asthma. We investigated the relationship between AMP and methacholine testing in children and adolescents with atopic asthma.MethodsThe medical records of 130 children with atopic asthma (mean age, 10.63 years) were reviewed retrospectively. Methacholine and AMP test results, spirometry, skin prick test results, and blood tests for inflammatory markers (total IgE, eosinophils [total count, percent of white blood cells]) were analyzed.ResultsThe concentration of AMP that induces a 20% decline in forced expiratory volume in 1 second [FEV1] (PC20) of methacholine correlated with the PC20 of AMP (r2=0.189, P<0.001). No significant differences were observed in the levels of inflammatory markers (total eosinophil count, eosinophil percentage, and total IgE) between groups that were positive and negative for BHR to methacholine. However, significant differences in inflammatory markers were observed in groups that were positive and negative for BHR to AMP (log total eosinophil count, P=0.023; log total IgE, P=0.020, eosinophil percentage, P<0.001). In contrast, body mass index (BMI) was significantly different in the methacholine positive and negative groups (P=0.027), but not in the AMP positive and negative groups (P=0.62). The PC20 of methacholine correlated with FEV1, FEV1/forced vital capacity (FVC), and maximum mid-expiratory flow (MMEF) (P=0.001, 0.011, 0.001, respectively), and the PC20 of AMP correlated with FEV1, FEV1/FVC, and MMEF (P=0.008, 0.046, 0.001, respectively).ConclusionsOur results suggest that the AMP and methacholine challenge test results correlated well with respect to determining BHR. The BHR to AMP more likely implicated airway inflammation in children with atopic asthma. In contrast, the BHR to methacholine was related to BMI.

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“…The conclusion of the MAS study agrees very well with the study of Castro-Rodriguez and our results. 34 Castro-Rodriguez et al showed that atopic asthmatic school children have greater BHR than nonatopic children. However, at infancy, both groups had similar BHR to methacholine.…”

Section: Discussionmentioning

confidence: 99%

Severe bronchial hyperresponsiveness along with house dust mite allergy indicates persistence of asthma in young children

Donath,

Klenner,

Hutter

et al. 2023

Pediatric Allergy Immunology

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BackgroundSignificant risk factors for persistence of asthma later in life are family history of allergies, early allergic sensitization and bronchial hyperresponsiveness (BHR). The evolution of BHR in young children without allergic sensitization and with house dust mite allergy (HDM) was investigated.MethodsIn this retrospective analysis, electronic charts of 4850 young children with asthma and wheezy bronchitis between 2005 and 2018 were reviewed in order to study all patients ≤6 years with BHR assessed by methacholine provocation tests (MCT) at least once (n = 1175). Patients with more than two follow‐up measurements were divided in group 1 (no allergic sensitization; n = 110) and group 2 (HDM allergy; n = 88). Additionally, skin prick test, exhaled nitrite oxide (eNO), and asthma treatment were analyzed.ResultsForty‐seven patients of group 1 aged median 4.3 years and 48 patients of group 2 aged median 4.7 years showed initially severe BHR <0.1 mg. At follow‐up, patients with HDM were more likely to show persistence of severe BHR than non‐sensitized patients (severe BHR group 1: n = 5 (10.6%) vs. group 2: n = 21 (43.8%), p < .001). In addition, 89.4% of group 1 had mild to moderate or no BHR, compared to only 56.2% of group 2. There was a significant difference in eN0 (median group 1: 9 ppb vs. group 2: 26 ppb, p < .001), at last follow‐up. Age, sex, and asthma therapy had no effect on BHR.ConclusionIn young children without sensitization BHR normalizes, whereas HDM allergy indicates a persistence of asthma beyond infancy.

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Bronchial Hyperreactivity to Methacholine in Atopic Versus Nonatopic Asthmatic Schoolchildren and Preschoolers

Cited by 11 publications

References 33 publications

Relationship Between Atopy and Bronchial Hyperresponsiveness

Relationship Between Atopy and Bronchial Hyperresponsiveness

Bronchial Hyperresponsiveness to Methacholine and AMP in Children With Atopic Asthma

Severe bronchial hyperresponsiveness along with house dust mite allergy indicates persistence of asthma in young children

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