Bronchial hyperresponsiveness as a phenotypic feature of chronic obstructive pulmonary disease

Трофименко, И. Н.; Черняк, Б. А.

doi:10.18093/0869-0189-2011-0-4-49-53

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…On the one hand, these pathological characteristics are relevant to disease symptoms, aggravation, treatment response, disease progression rate, and mortality and can evaluate the prognosis of the disease [ 23 ]. On the other hand, they can reflect the differences among COPD patients, including differences in the prognosis and treatment schemes, which are conducive to guiding individualized treatment of the disease [ 4 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Evaluation of Chronic Obstructive Pulmonary Disease and Risk Prediction of Acute Exacerbation by High-Resolution Computed Tomography

Hua

Chen

Yin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. It is imperative to popularize the tertiary prevention of chronic obstructive pulmonary disease (COPD) and to improve the diagnosis and treatment. Methods. COPD patients were divided into mild (n = 18), moderate (n = 20), severe (n = 24), and extremely severe (n = 22) groups for performing high-resolution computed tomography (HRCT) and pulmonary function test. Serum procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) were detected, and the occurrence rate of acute exacerbation COPD (AECOPD) was recorded during a 12-months follow-up period. Results. With an increase in the severity grade, the HRCT indexes, including emphysema index (EI), 1st and 15th percentile of inspiratory attenuation distribution (Perc1 and Perc15), ratio of expiratory/inspiratory mean lung density (MLDex/in) and lung volume (LVex/in), and ratio of the wall thickness to the outer diameter of the lumen (TDR), as well as percentage of the wall area to the total cross-sectional area (WA%) were increased with a decreased change in relative lung volume with attenuation values between −860 and −950 HU (RVC−860to −950) and lumen area (Ai). These were correlated with the ratio of forced expiratory volume in 1 sec (FEV1) over forced vital capacity (FVC) (FEV1/FVC), the percentage of FEV1 the predicted value (FEV1%), and ratio of residual volume to total lung volume (RV/TLC). Body mass index, MLDex/in, FEV1%, FEV1/FVC, and PCT had a predictive value to AECOPD, with the combined AUC of 0.812. Conclusions. HRCT imaging effectively classifies the severity of COPD, which combined with BMI, PFT, and serum PCT can predict the risk of AECOPD.

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Section: Discussionmentioning

confidence: 99%

Quantitative Evaluation of Chronic Obstructive Pulmonary Disease and Risk Prediction of Acute Exacerbation by High-Resolution Computed Tomography

Hua

Chen

Yin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Main scintigraphic parameters of patients with chronic obstructive pulmonary disease

Lishmanov¹,

Кривоногов²,

Ageyeva³

et al. 2012

Bûll. sib. med.

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У 25 пациентов с хронической обструктивной болезнью легких (ХОБЛ) I-II стадии изучены диагностические возможности вентиляционно-перфузионной пульмоносцинтиграфии в оценке нарушений легочной микроциркуляции и вентиляции. Сцинтиграфические исследования выполнены на гамма-камере «Омега-500» (Technicare, США -Германия). При ХОБЛ обнаружено двухстороннее увеличение апикально-базального градиента перфузии и замедление альвеолярнокапиллярной проницаемости. Выявленные изменения сцинтиграфических показателей могут быть использованы в диагностике ХОБЛ.Ключевые слова: хроническая обструктивная болезнь легких, альвеолярно-капиллярная проницаемость, апикальнобазальные градиенты перфузии и вентиляции.We examined 25 patients with Stage I-II COPD to study diagnostic capabilities of ventilation-perfusion pulmoscintigraphy in relation to the assessment of lung microcirculation and ventilation disorders. Scintigraphic studies were performed by means of the Omega 500 gamma camera (Technicare, USA -Germany). COPD is characterized with the bilateral increase in the apical-basal grade of perfusion and deceleration of the alveolar-capillary permeability. The detected changes of scintigraphic parameters can be used in COPD diagnostics.

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Bronchial hyperresponsiveness as a phenotypic feature of chronic obstructive pulmonary disease

Cited by 2 publications

References 17 publications

Quantitative Evaluation of Chronic Obstructive Pulmonary Disease and Risk Prediction of Acute Exacerbation by High-Resolution Computed Tomography

Quantitative Evaluation of Chronic Obstructive Pulmonary Disease and Risk Prediction of Acute Exacerbation by High-Resolution Computed Tomography

Main scintigraphic parameters of patients with chronic obstructive pulmonary disease

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