Bronchial Hyperresponsiveness in Children with Atopic and Nonatopic Asthma

Mochizuki, Hiroyuki; Mitsuhashi, Masato; Shigeta, Makoto; Tokuyama, Kenichi; Tajima, Kohei; Morikawa, Akihiro; Kuroume, Takayoshi

doi:10.3109/02770908709070924

Cited by 16 publications

(20 citation statements)

References 5 publications

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“…11,15 Recently, van Broekhoven and Wilts reported on the measurement of BHR using the tcPO 2 method; they described its convenience and safety in young children. 12,25 During acute attacks of asthma, it is known that changes in tcPO 2 are linearly related to the severity of the asthma attacks.…”

Section: Discussionmentioning

confidence: 99%

“…Using a tcPO 2 -monitoring method described elsewhere, 11,14 we performed methacholine inhalation challenge on all of the subjects.…”

Section: Methodsmentioning

confidence: 99%

“…A previously described tcPO 2 monitoring system was used to measure the results. 11,15 The challenge was performed during sleep in the supine position after trichlorethyl phosphate monosodium syrup (70 mg/kg) was administered. An oxygen mask allowing a constant bias flow was used.…”

Section: Methacholine Inhalation Challengementioning

confidence: 99%

“…BHR can be shown when tcPO 2 falls. 11 Although changes in tcPO 2 in infants during methacholine challenge only suggest airway smooth muscle constriction, 12 this noninvasive method may be helpful to demonstrate respiratory disorders in infants. In this study we performed methacholine inhalation challenge in infants with CLD and age-matched controls by using tcPO 2 monitoring to assess the degree of airway damage.…”

Section: Introductionmentioning

confidence: 99%

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Transcutaneous oxygen tension measurements during methacholine challenge of prematurity in infants with chronic lung disease

et al. 1998

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Section: Discussionmentioning

confidence: 99%

“…Using a tcPO 2 -monitoring method described elsewhere, 11,14 we performed methacholine inhalation challenge on all of the subjects.…”

Section: Methodsmentioning

confidence: 99%

Section: Methacholine Inhalation Challengementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcutaneous oxygen tension measurements during methacholine challenge of prematurity in infants with chronic lung disease

et al. 1998

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“…Thus, a decrease in Dmin or in PD 35 -Grs indicates an increase in airway hyperresponsiveness, and an increase in Dmin or in PD 35 -Grs indicates a decrease in airway hyperresponsiveness. Previous studies have reported a significant correlation between the bronchial hyperresponsiveness measured by an astograph and those measured by conventional methods, and showed the clinical usefulness of the astograph [14,15,16,17]. …”

Section: Methodsmentioning

confidence: 99%

Once-Daily Administration of Fluticasone Propionate Does Not Worsen Controlled Airway Hyperresponsiveness in Patients with Asthma

Shigyo

Inoue²,

Honda³

et al. 2005

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Background: Inhaled steroids are currently the most important drugs for asthma patients, but compliance tends to be low. Compliance could be improved by reducing the number of daily administrations. Objectives: In the present study, we compared once- and twice-daily administration of fluticasone propionate (FP) to determine the differences in efficacy. Methods: Subjects were 40 patients diagnosed with bronchial asthma with stable symptoms and pulmonary functions who were on twice-daily FP administration of 100 µg. There were 14 men and 26 women ranging from 29 to 72 years of age. After a 4-week observation period, subjects were randomized into two administration groups by the envelope method and followed for 8 weeks: group A, once-daily administration (200 µg of FP at night), and group B, twice-daily administration (100 µg of FP in the morning and at night). Clinical symptoms, pulmonary functions and airway responsiveness were compared between these two groups. Results: No significant deterioration in clinical symptoms, pulmonary functions and airway responsiveness were observed in group A compared with group B. Conclusions: These results demonstrate that once-daily FP administration is as effective as twice-daily administration, and that it may improve the compliance for inhaled steroids.

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Effect of age, height, and prechallenge respiratory resistance on bronchial hyperresponsiveness in childhood asthma using the forced oscillation technique

et al. 1996

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To evaluate the effects of age, height and prechallenge respiratory system resistance (Rrs) on bronchial responsiveness to methacholine inhalation (BRm) as measured by the oscillation technique in children with mild asthma, we studied BRm in 92 atopic children aged from 8 to 13 years (mean ± SD, 10.5 ± 1.7 years). Inhalation challenge was performed by administering progressively doubling doses of methacholine, until a twofold increase in Rrs from baseline had been reached. The minimum cumulative dose of methacholine (Dmin) at which Rrs deviated from baseline was identified by the point of deflection of the continuously recorded Rrs tracing. The Dmin represented the amount of methacholine which elicited BRm. By using single‐regression analysis, height was negatively correlated with Rrs (p < 0.001). Height was positively and Rrs was negatively correlated with age (p < 0.001 and p < 0.001, respectively). Furthermore, height and age were correlated with Dmin (p < 0.001 and p < 0.001, respectively), but prechallenge Rrs was not correlated with Dmin (p > 0.1). To minimize the effect of height and prechallenge Rrs on BRm, the relationships between Dmin and age was studied in a subgroup with a narrow range of heights (135–155 cm, n = 32), and a narrow range of prechallenge Rrs (5.0–6.9 cmH2 O/L/s, n = 42); there remained a statistically significant correlation between Dmin and age in the groups with comparable heights (p = 0.026) and Rrs (p = 0.003). These data suggest that the BHR in childhood asthma may be affected by height and age when measured by the oscillation technique. Considering the many advantages of the oscillation method, this technique may be very suitable for measuring BHR in childhood asthma. Pediatr Pulmonol. 1996;22:1–6. © 1996 Wiley‐Liss, Inc.

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Bronchial Hyperresponsiveness in Children with Atopic and Nonatopic Asthma

Cited by 16 publications

References 5 publications

Transcutaneous oxygen tension measurements during methacholine challenge of prematurity in infants with chronic lung disease

Transcutaneous oxygen tension measurements during methacholine challenge of prematurity in infants with chronic lung disease

Once-Daily Administration of Fluticasone Propionate Does Not Worsen Controlled Airway Hyperresponsiveness in Patients with Asthma

Effect of age, height, and prechallenge respiratory resistance on bronchial hyperresponsiveness in childhood asthma using the forced oscillation technique

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