Bronchial hyperresponsiveness to 4.5% hypertonic saline indicates a past history of asthma-like symptoms in children

Meta-analysis of the association of β2-adrenergic receptor polymorphisms with asthma phenotypes

“…44 Importantly, bronchial hyperresponsiveness seems related to wheezing and dyspnea but not to nocturnal cough. 43 Misclassification of phenotypes is also a concern to some extent for the other phenotypes examined here, because the original study definitions were sometimes described in suboptimal detail.…”

“…Nevertheless, airway hyperresponsiveness is not equivalent to asthma. Bronchial hyperresponsiveness correlates modestly with past history of asthma-like symptoms 43 and subsequent development of asthma. 44 Importantly, bronchial hyperresponsiveness seems related to wheezing and dyspnea but not to nocturnal cough.…”

Are oral contraceptive use and pregnancy complications risk factors for atopic disorders among offspring?

“…Nevertheless, the validity of ‘early morning coughing’ as a marker for asthma has been found to be sufficient (45, 46). Furthermore, it has been shown that bronchial hyper‐reactivity was not related to dry cough or to nocturnal cough (47). According to Chang, coughing and bronchoconstriction may be caused by different mechanisms.…”

Guidelines for Evaluating Chronic Cough in Pediatrics

“…Furthermore, other than the validity of using dry/wet cough and brassy/nonbrassy in children, 17 there are few data on the validity of other cough characteristics and/or clinical examination. 66,73,74,79,80,88,89,94,103,105,106,117,[252][253][254][255][256][257][258][259][260][261] As chronic cough can be associated with significant consequences (eg, a retained foreign body causing bronchiectasis), each child with chronic cough should be thoroughly reviewed and when appropriate relevant investigations should be performed. The data are summarized in Table 2.…”