Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens

Panzner, Petr; Malkusová, Ivana; Vachová, Martina; Liška, M.; Brodská, Petra; Růžičková, Olga; Malý, Marek

doi:10.1016/j.aller.2013.06.009

Cited by 21 publications

(34 citation statements)

References 38 publications

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“…It has been reported that allergic rhinitis can cause asymptomatic lower airway eosinophilic inflammation and BHR. 9,10 This eosinophilic inflammation was decreased with the avoidance of allergens, 11 and BHR was reversible after corticosteroids treatment. 12 In our study, only a few patients with NAEB or CVA had a history of allergic rhinitis (26.92%, n = 7, data not shown).…”

Section: Discussionmentioning

confidence: 96%

Eosinophilic airway inflammation is common in subacute cough following acute upper respiratory tract infection

et al. 2016

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Background and objective: Patients presenting with refractory postinfectious cough may respond to glucocorticosteroids but it is unclear whether airway eosinophilic inflammation exists in those patients. We aimed to determine the airway inflammation and causes of subacute cough following acute upper respiratory tract infection (AURTI). Methods: One hundred and sixteen patients with persistent cough lasting 3-8 weeks after upper respiratory tract infection were evaluated with differential cell count in induced sputum, spirometry and methacholine bronchial challenge testing. Results: In patients with subacute cough, sputum eosinophilia (median 8.5%,3.0-73.0%) was identified in 35 (33.6%) patients, 22 (18.5%) without bronchial hyperresponsiveness (BHR) were diagnosed as nonasthmatic eosinophilic bronchitis (NAEB), 13 (14.3%) of whom with BHR were diagnosed as cough variant asthma (CVA). Cough in patients with sputum eosinophilia improved after treatment with corticosteroids. Compared with postinfectious cough (PIC) and NAEB, CVA had significantly higher median eosinophil count in induced sputum (0.5% vs 7.5% vs 20.0%, P < 0.01). MMEF in CVA was significantly lower than PIC and NAEB (P < 0.05). The common causes of subacute cough following acute upper respiratory tract infection (AURTI) were PIC (37.8%), NAEB (18.5%), CVA (14.3%) and upper airway cough syndrome (UACS) (10.1%). Atopic cough (AC) (5.2%) and gastroesophageal refluxrelated cough (GERC) (3.4%) were less common in subacute cough following AURTI, while 9 (7.8%) patients had unexplained cough. Conclusion: Subacute cough following AURTI can be attributed to different entities, eosinophilic airway inflammation is common. Induced sputum should be considered when evaluating patients with subacute cough following acute upper respiratory tract infection.

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Section: Discussionmentioning

confidence: 96%

Eosinophilic airway inflammation is common in subacute cough following acute upper respiratory tract infection

et al. 2016

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“…Unfortunately, due to the poor response to the question regarding the specific allergen that patients are allergic to, we could not identify possible environmental allergens in our community beside dust. It is believed that environmental factor play a major role in developing the disease [11]. Education of the disease and its impact on asthmatic patients, their quality of life and the environmental association will increase the awareness and disease prevention [12].…”

Section: Discussionmentioning

confidence: 99%

Cross Sectional Study: Prevalence of Allergic Rhinitis among Adult Asthmatic Patients in Kuwait.

Alkhaldy¹,

Abdelhamy²,

Alsaeedi³

2018

Arch Gen Intern Med

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Background: Allergic rhinitis is prevalent co-morbidity among asthmatic patients. The literature has suggested that it is responsible for poor asthma control. Also, it was found to be an important risk factor for developing of asthma in general population. In Kuwait there are no previous studies that estimated the prevalence of such an association. This study conducted to evaluate the prevalence of allergic rhinitis on adult bronchial asthma in a single center in Kuwait and to examine other common associations.Material and methods: This is a cross sectional study in a single center to evaluate the prevalence and allergic rhinitis and its effect on asthma management among adults. The data was collected through a distribution of an online questionnaire the score for allergic rhinitis (SFAR) to known asthmatic patients who were diagnosed previously with bronchial asthma in a period of six weeks between January and February 2018. Analyzed, discussed and compared to other relevant study.Results: 494 asthmatic patients participated in the questionnaire in a period of 6 weeks. 74.7% were females and 25.3% was males. 39.7% of patients were obese and 13% were smokers. The vast majority of asthmatic patients experienced symptoms of allergic rhinitis in the past 12 months. The most common symptoms experienced were; sneezing (48%), nose itching (45.5%), and cough (35.6%), moreover, 34.4% had runny nose. and 20.9% have had their eyes itching. Interestingly sneezing showed a decreasing prevalence as getting older among males but not females, also runny nose showed biphasic course among age groups. Two thirds (69.4%) of the patients were not using any rhinitis medications.Conclusion: Allergic rhinitis is a common co-morbidity among asthmatic adult patients in our study in Kuwait. The vast majority of patients were not using their rhinitis treatment. Better patient education and adherence to treatment is warranted. Further studies needed to assess the impact of rhinitis treatment on asthma control in Kuwait. AbstractCross sectional study: Prevalence of allergic rhinitis among adult asthmatic patients in Kuwait.

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“…Persistent inflammation of lower airway in periods without allergen exposure was proven in seasonal asthma. This may have implications for the therapy of seasonal allergic rhinitis with and without asthma in terms of promoting long-term anti-inflammatory treatment 20 . Okubo K et al (2014), worked on the Japanese guideline for Allergic Rhinitis 2014 like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease.…”

Section: Drug Utilization Studies In Ent Treatmentsmentioning

confidence: 99%

Drug utilization studies among ENT patients in various clinical settings: A comprehensive review

Rasool¹,

Maqbool

Joshi³

2019

J. Drug Delivery Ther.

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Drug utilization research is thus an all important part of pharmacoepideminology as it explains the extent, nature and determinants of drug exposure. A drug utilization study is a tool for determining the effectiveness of drug use. They have tendency to create sound economic bases for health care. It focuses on various factors related to prescribing, dispensing, and administration of medication and associated events. It is a study which is used for analyzing or describe-quantitatively and qualitatively- the population of users of a given drug (or class of drug) and/or the condition of use (for example, indication, duration of treatment, dosage, previous or associated treatment and compliance). ENT problems have been counted as prominent as well as commonly occurring medical problem for our society. It is a problem of most concern. Drug utilization studies can play a major role to identify the nature of therapy used in their treatment and also helps to promote the rationality and minimizing the errors in the drug therapy. Such kind of studies can be helpful for healthcare practitioners as well as to the society against such health issues. Drug utilization research developed quickly during the following 30 years and soon became a respectable subject for consideration at international congresses in pharmacology, pharmacy and epidemiology. Successful research in drug requires multidisciplinary collaboration between clinicians, clinical pharmacologists, pharmacists and epidemiologists. Without the support of the prescribers, this research effort will fail to reach its goal of facilitating the rational use of drugs. In this review, we will briefly list various Drug utilization studies in ENT Clinical settings. Keywords: Drug utilization studies, ENT, Prescribing patterns, Rational prescribing, Pharmacoepideminology

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Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens

Cited by 21 publications

References 38 publications

Eosinophilic airway inflammation is common in subacute cough following acute upper respiratory tract infection

Eosinophilic airway inflammation is common in subacute cough following acute upper respiratory tract infection

Cross Sectional Study: Prevalence of Allergic Rhinitis among Adult Asthmatic Patients in Kuwait.

Drug utilization studies among ENT patients in various clinical settings: A comprehensive review

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