Bronchial Nitric Oxide Flux and Alveolar Nitric Oxide Concentration After Exposure to Hyperoxia

Abstract

This file was dowloaded from the institutional repository Brage NIH -brage.bibsys.no/nih Caspersen, C., Stensrud, T., Thorsen, E. (2011)

Application of Exhaled Nitric Oxide in Pulmonary Oxygen Toxicity

“…Consistent with their previous fi ndings (3;Ref. 27), a single 90-min HBO treatment session could reduce FeNO.…”

Assessment of pulmonary oxygen toxicity: Relevance to professional diving; a review

“…To distinguish between the conductive and alveolar compartment the multiple exhalation flow technique must be used with an exhalation flow rate of at least 250 mL s −1 (Geigel et al, 1999;George et al, 2004;Hogman et al, 2009;Shin et al, 2001;Tsoukias et al, 2001). Using this multiple exhalation flow technique significant decreases in FE NO from solely the conductive compartment were found (Caspersen et al, 2011). However, as oxygen was breathed in a dry environment it remains unclear whether these results also apply for submerged oxygen breathing divers.…”

Oxygen Toxicity and Special Operations Forces Diving: Hidden and Dangerous

“…The current prediction model (UPTD) was developed in dry setting during a time when capabilities to measure lung parameters were limited. Newer parameters, such as, the ratio between diffusion capacity of carbon monoxide and nitric oxide (DL NO/CO ), fraction of exhaled nitric oxide (FE NO ) or volatile organic compounds (VOCs), might be more accurate in determining POT, but these tests have yet to be validated (Shykoff, 2008a,b; Caspersen et al, 2011; van Ooij et al, 2014b,a, 2016; Vermeulen et al, 2016). Especially the VOCs are of interest because, in the field of pulmonology, this noninvasive diagnostic modality is increasingly utilized for diagnosing asthma, acute respiratory distress syndrome and lung cancer (Bos et al, 2014, 2016; Boots et al, 2015).…”