Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment

Zanini, Andrea; Chetta, Alfredo; Saetta, Marina; Baraldo, Simonetta; Castagnetti, Claudia; Nicolini, Gabriele; Neri, Margherita; Olivieri, Dario

doi:10.1136/thx.2009.114629

Cited by 34 publications

(45 citation statements)

References 36 publications

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“…In COPD, vascular remodelling involves angiogenesis, heterogenic bronchial vascularisation and structural changes of the vascular wall [119]. Patients with COPD present vessels with increased arterial stiffness [96]; the vessels are less elastic and correlate with disease severity [120], probably due to altered ECM structure [121].…”

Section: Vascular Changes and Growth Factors In Copdmentioning

confidence: 99%

“…It has been shown that patients with acute exacerbations present high levels of VEGF in the circulation compared to stable COPD patients and healthy individuals [128]. In a small study with bronchial biopsies, patients without glucocorticosteroid treatment showed more bronchial vascularisation, larger vessels and more VEGF receptors expressed in the tissue compared to COPD patients that were treated with inhaled glucocorticosteroids [119]. Interestingly, VEGF has been shown to act both as a promoter of endothelial cell function and a negative regulator of VSMCs and vessel maturation in combination with PDGF [34], highlighting the complex role of VEGF in vascular remodelling.…”

Section: Vascular Changes and Growth Factors In Copdmentioning

confidence: 99%

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Pulmonary vascular changes in asthma and COPD

Harkness

Kanabar

Sharma

et al. 2014

Pulmonary Pharmacology & Therapeutics

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In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.

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Section: Vascular Changes and Growth Factors In Copdmentioning

confidence: 99%

Section: Vascular Changes and Growth Factors In Copdmentioning

confidence: 99%

Pulmonary vascular changes in asthma and COPD

Harkness

Kanabar

Sharma

et al. 2014

Pulmonary Pharmacology & Therapeutics

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“…αvβ3 integrin is an adhesion molecule that is upregulated in new vessel proliferation in response to angiogenic stimuli, while it is downregulated or absent on resting endothelium (34). Zanini et al (15) assessed bronchial vascular remodelling in the central airways of COPD patients and showed that in these subjects the bronchial vascular area and vessel size were increased. Furthermore, they observed an increased expression of VEGF, bFGF, and transforming growth factor-beta (TGF-β) in COPD patients, as compared to controls, providing the evidence of the strong relation between the vascular component of airway remodelling and the bronchial expression of VEGF and TGF-β.…”

Section: Angiogenesis and Bronchial Vascular Remodelling In Copdmentioning

confidence: 99%

“…Most of the literature regarding angiogenesis and bronchial vascular remodelling in chronic airway inflammation arises from studies on asthmatic patients (8)(9)(10)(11)(12). Interestingly, it has been recently shown that bronchial vascular changes may also occur in COPD (13)(14)(15). It is reported that bronchial microcirculation can develop qualitative and quantitative alterations such as vasodilatation, increased permeability and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Angiogenesis and bronchial vascular remodelling in asthma and COPD

Zanini¹

2013

SOB

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“…Notably, an increased bronchial vascular area was a common feature in COPD patients, at least in part as a result of increased expression of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β [14,15,16]. …”

Section: Introductionmentioning

confidence: 99%

Decreased Maturation of Dendritic Cells in the Central Airways of COPD Patients Is Associated with VEGF, TGF-β and Vascularity

et al. 2014

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Background: Dendritic cells (DCs) have a pivotal role in the onset and regulation of innate and adaptive immune responses. Moreover, DCs can interact with angiogenic modulators, resulting in modification of their biology and participation in angiogenesis. Objectives: This study was designed to evaluate the relationship between the density of DCs, vascularity and expression of angiogenic factors [vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β and basic fibroblast growth factor (bFGF)] in the central airways of chronic obstructive pulmonary disease (COPD) patients. Methods: The study included 20 patients with moderate/severe COPD and 8 healthy control subjects. Bronchial biopsies were evaluated by immunohistochemistry. Specimens were examined for CD83 and CD207 to mark mature and immature DCs, respectively, for collagen IV to evaluate vascularity, and for VEGF, TGF-β and bFGF. Results: Compared to controls, COPD patients had a significant reduction of CD83+ cells and an increased CD207/CD83 ratio (p < 0.05). Vascularity, VEGF, TGF-β and bFGF were also significantly increased in COPD patients as compared to controls (p < 0.01). In COPD patients, CD83+ cells were inversely related to VEGF and TGF-β expression (p < 0.05). Moreover, the CD207/CD83 ratio was positively related to VEGF, TGF-β and vascularity (p < 0.05). Finally, CD207+ cells were inversely related to FEV₁ (p < 0.05). Conclusion: Our results show a reduced maturation of DCs in COPD that was related to airway vascularity and angiogenic factors (VEGF and TGF-β). Additionally, immature DCs were significantly related to disease severity. We propose that the interplay between airway vascular changes, on one hand, and DCs maturation on the other, may play a key role in the pathogenetic mechanisms of COPD.

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Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment

Cited by 34 publications

References 36 publications

Pulmonary vascular changes in asthma and COPD

Pulmonary vascular changes in asthma and COPD

Angiogenesis and bronchial vascular remodelling in asthma and COPD

Decreased Maturation of Dendritic Cells in the Central Airways of COPD Patients Is Associated with VEGF, TGF-β and Vascularity

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