Bronchiectasis

Kartagener's Syndrome - Revisited

“…Coordinated sliding and bending action cannot OCGur in the absence of dynein arms or radial spokes. Such abnormalities prevent normal transport of mucus from the bronchial tree to the mouth and result in a serious impairment of the lung's normal, de› fence system [2].…”

“…The clinical features are a result of defec› tive mucociliary clearance from the respira› tory tracts, the para-nasal sinuses and the middle ear [1][2][3][4]. Repeated insults by viruses, bacteria and other microorganisms over a pe› riod of time, with delayed clearance of the mucopurulent material leads to increasing damage of respiratory epithelium, thereby re› sulting in bronchiectasis.…”

“…artagener's syndrome belongs to the 'dyskinetic cilia syndrome' group and is a syndromal association of bron› chiectasis, sinusitis and dextrocardia [1,2]. The dextrocardia in over half the cases is associated with situs inversus, and only about 12 to 25% cases exhibit the complete triad.…”

“…The dextrocardia in over half the cases is associated with situs inversus, and only about 12 to 25% cases exhibit the complete triad. The other reported associations are oti› tis media with mild conductive deafness [2], infertility in males due to immotile sperma› tozoa, and in females due to tube dysfunction.…”

Chronic pulmonary suppuration

“…The differential diagnoses to be considered in a patient with chronic pulmonary suppurative symptoms include bronchiectasis, lung abscess, and cystic fibrosis, The causes of bronchiectasis can be congenital or acquired1 as shown in box 1.…”