Bronchiolitis-Associated Hospitalizations Among US Children, 1980-1996

Shay, David K.; Holman, Robert C.; Newman, Robert D.; Liu, Lenna L.; Stout, James; Anderson, Larry J.

doi:10.1001/jama.282.15.1440

Cited by 1,271 publications

(906 citation statements)

References 33 publications

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“…Our results are in accordance with findings in a descriptive analysis of US National Discharge Survey data from 1980 through 1996 [11]. All discharge records from children younger than 5 years of age with an ICD-9 code (ICD-10 codes were not introduced until April 1995) for any respiratory illness among the diagnoses listed were selected for this study.…”

Section: Discussionsupporting

confidence: 87%

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Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995–March 1998

Müller‐Pebody¹,

Edmunds²,

Zambon

et al. 2002

Epidemiol. Infect.

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SUMMARYEstimates of the number of hospitalizations attributable to specific pathogens are required to predict the potential impact of vaccination. All hospital admissions for lower respiratory tract infection (LRI) in children 5 years in England in 1995-8 were reviewed. Most admissions (76n8 %) were not associated with specific organisms. Seasonality in pathogens that cause bronchiolitis and pneumonia was used to predict the proportion of cases with unspecified aetiology attributable to different organisms using multiple linear regression. Of 12 298 admissions for LRI, 17n5 % were due to RSV infection. An estimated 74n8 % (95 % CI, 72n0-77n7 %) of ' unspecified bronchiolitis ' admissions and 16n3 % (95 % CI, 13n7-18n8%) of ' unspecified pneumonia ' admissions were RSV related. The total mean annual incidence of hospital admissions attributable to RSV is 28n3\1000 children 1 year of age, and 1n3\1000 children 1-4 years old. The greater burden of RSV infection than indicated through discharge data is revealed through applying simple statistical methods.

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Section: Discussionsupporting

confidence: 87%

“…However, a substantial increase in rates of hospitalization of infants with bronchiolitis during 1980-96 was also seen in an American study [11]. Furthermore, attendance at a child-care centre is considered to be an independent risk factor for LRI hospitalization in children under 2 years of age [12].…”

Section: Discussionmentioning

confidence: 99%

Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995–March 1998

Müller‐Pebody¹,

Edmunds²,

Zambon

et al. 2002

Epidemiol. Infect.

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“…The incidence rates obtained from confirmed cases in our study are similar to those obtained from estimations based on the number of patients hospitalized with a clinical diagnosis of bronchiolitis and other lower respiratory illnesses in other countries [14 -16]. In the national estimates performed in the USA by Shay et al [14] the annual hospitalization rate for bronchiolitis in 1996 was 31 . 2/1000 in infants younger than 1 year.…”

Section: Discussionsupporting

confidence: 85%

Hospitalization for respiratory syncytial virus in the paediatric population in Spain

et al. 2003

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SUMMARYThe aim of this population-based retrospective study was to determine the incidence of hospitalization for community-acquired, laboratory-confirmed respiratory syncytial virus (RSV) infection in an unselected paediatric population from southern Europe. The study was performed in an area with 15 700 children aged less than 5 years attended by a single hospital. The presence of RSV in nasopharyngeal aspirates from children with acute respiratory infection treated in the hospital was investigated in four seasons (July 1996-June 2000. A total of 390 episodes of hospitalization for RSV infection were detected and 83 . 3% of the children were aged less than 1 year old. The annual hospitalization rate was 37/1000 for infants aged less than 6 months and 25/1000 for those aged less than 1 year. During the study period, 2 . 5 % of the infants younger than 1 year and approximately 5 % of those younger than 3 months were hospitalized for RSV infection. The mean length of hospital stay was 5 . 9 days. Seven per cent of the patients required admission to the intensive care unit and more than half of these children were aged less than 1 month. In Spain, community-acquired RSV infection is a highly frequent cause of hospitalization in young children, especially in those aged less than 1 year. Prevention of RSV infection, through the development of vaccines and/or other strategies, should be a public health priority.

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“…1 In the United States, RSV-associated bronchiolitis has been estimated as the cause of up to 126 300 hospitalizations annually for children younger than 5 years 1 and is the leading cause of hospitalization for infants younger than 1 year. 2 The RSV-associated all-cause mortality rate is 5.4 per 100 000 person-years for infants younger than 1 year.…”

Section: Introductionmentioning

confidence: 99%

Prevention of hospitalization due to respiratory syncytial virus: results from the Palivizumab Outcomes Registry

Frogel

Nerwen

Cohen³

et al. 2008

J Perinatol

103

108

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Objective: The Palivizumab Outcomes Registry contains data on infants and young children who received palivizumab for the prevention of respiratory syncytial virus (RSV) that causes serious lower respiratory tract illness.Study Design: Prospective observational registry enrolling those who received X1 dose of palivizumab during any RSV season (2000 to 2004) at participating US sites.Result: Of 19 548 subjects enrolled, 40% were born before 32 weeks', 48% between 32 and 35 weeks' and 12% after 35 weeks' gestation. Risk factors included child-care attendance, prematurity, chronic lung disease (CLD) and congenital heart disease (CHD). The RSV hospitalization rate of palivizumab recipients was 1.3%. Gender, gestational age <32 weeks, CLD, CHD, congenital airway abnormality, severe neuromuscular disease, Medicaid insurance and >2 children in household were associated with significantly higher rates. Home-care prophylaxis with palivizumab was associated with reduced hospitalization rates.Conclusion: Data on the use of palivizumab prophylaxis in primarily high-risk infants confirm low RSV hospitalization rates.

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Bronchiolitis-Associated Hospitalizations Among US Children, 1980-1996

Cited by 1,271 publications

References 33 publications

Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995–March 1998

Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995–March 1998

Hospitalization for respiratory syncytial virus in the paediatric population in Spain

Prevention of hospitalization due to respiratory syncytial virus: results from the Palivizumab Outcomes Registry

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