Bronchiolitis Obliterans with Organizing Pneumonia in a Dog

Phillips, Stephanie L.; Barr, Stephen C.; Dykes, Nathan L.; Scrivani, Peter V.; Kraus, Marc S.; Rishniw, Mark; Valentine, Beth A.

doi:10.1111/j.1939-1676.2000.tb02238.x

Cited by 8 publications

(12 citation statements)

References 19 publications

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“…The mean age in human beings who develop COP is 50–60 years (Cordier 2006), but this case report included a young dog. In the previous two canine reports, the ages were eight years in the single case report and a mean age of 7.7 years (range 2–16 years) in the case series (Phillips and others 2000, Norris and others 2002). Both the dogs in this study had presented with symptoms virtually identical to each other as well as persistent pyrexia and cough, reduced exercise tolerance and submandibular lymphadenopathy, which were included in the previous reports.…”

Section: Discussionmentioning

confidence: 97%

“…Additionally, the human cases show complete resolution of CT lesions after corticosteroid therapy with only, in a few cases, small residual remnant consolidations. The CT findings in the first reported case of canine COP were bilateral asymmetric areas of air space consolidation (Phillips and others 2000). A CT performed in Case 1 had typical multifocal subpleural and peribronchial poorly defined nodular opacities, ground glass opacities as well as parenchymal bands.…”

Section: Discussionmentioning

confidence: 99%

“…The pathology was described as alveolitis with typical fibrovascular polyps, high-density capillary vasculature, necrosis and mixed inflammatory cells with intra-alveolar type II pneumocytes, foamy macrophages, protein-rich fluid and neutrophils. Additionally, there was bronchiolar wall smooth muscle hypertrophy with the lumen often obliterated by fibroblasts and exudate (Phillips and others 2000, Norris and others 2002, Li and others 2006). …”

Section: Introductionmentioning

confidence: 99%

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Steroid‐responsive idiopathic interstitial lung disease in two dogs

Köster

Kirberger

2014

Vet Record Case Reports

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Two dogs had a history of persistent pyrexia, reduced exercise tolerance, inappetence and coughing and failed to respond to repeated courses of antibiotics. Clinical examination detected adventitious lung sounds, pyrexia and submandibular lymphadenopathy. Haematology revealed an inflammatory leucogram. Both dogs had radiological abnormalities consistent with a multifocal interstitial lung pattern. CT performed in one dog had characteristic changes of cryptogenic organising pneumonia (COP), an extremely rare idiopathic interstitial lung disease. Findings included several parenchymal bands, multifocal patchy ground-glass opacities and multifocal subpleural and peribronchial hyperattenuating poorly defined nodular opacities throughout the lungs. Bronchoalveolar lavage revealed a sterile suppurative exudate, excluding eosinophilic bronchopneumopathy. There was rapid resolution of clinical and radiological signs, with corticosteroids and relapse in one dog after discontinuation of steroids supporting the diagnosis of this rare condition. Lung biopsy, which was not performed in either case, is definitive but considered invasive with major complications reported including death.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Steroid‐responsive idiopathic interstitial lung disease in two dogs

Köster

Kirberger

2014

Vet Record Case Reports

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“…Chronic obstructive pulmonary disease (COPD) has been reported sporadically in dogs 10,11 . In people it is more prevalent and is oftentimes associated with exposure to cigarette smoke.…”

Section: Diagnosis/outcomementioning

confidence: 99%

Characterization of Severe Small Airway Disease in a Puppy Using Computed Tomography

Winters

Tidwell

Rozanski

et al. 2006

Vet Radiology Ultrasound

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A young Golden Retriever dog developed severe respiratory distress following an initial clinical diagnosis of infectious tracheobronchitis. Severe expiratory flow limitation, associated with exertional respiratory distress and hypoxemia was present. Thoracic images obtained with conventional radiography were characterized by hyperinflation and abnormal bronchial and alveolar patterns. Computed tomography was performed and in conjunction with pulmonary functional changes was diagnostic of small airway disease. The dog was treated with a variety of antibiotics, anti-inflammatory agents, and antitussives, but the clinical signs worsened and the puppy was euthanized. Pathologic examination confirmed severe small airway disease, with emphysema and bronchiolitis.

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“…Several types of ILD, including IPF, bronchiolitis obliterans with organizing pneumonia (cryptogenic organizing pneumonia), eosinophilic pneumonia, endogenous lipid pneumonia, and pulmonary alveolar proteinosis, have been previously reported in dogs [ 6 , 14 , 24 , 25 , 26 , 30 ]. In this case, the histopathological findings were inconsistent with those previously reported for ILD.…”

mentioning

confidence: 99%

Pulmonary hypertension due to unclassified interstitial lung disease in a Pembroke Welsh corgi

Morita

Nakamura

Osuga

et al. 2018

The Journal of Veterinary Medical Science

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A 12 year-old intact male Pembroke Welsh corgi weighing 10.8 kg was presented for evaluation of a 3-month history of dyspnea, and a 1-week history of exercise intolerance and anorexia. Severe hypoxemia (PaO2 56 mmHg), diffuse lung alveolar infiltration, and severe pulmonary hypertension (PH) (tricuspid regurgitation pressure gradient was 81 mmHg) were identified. A tentative diagnosis of severe PH due to lung disease or pulmonary thromboembolism was made and treated intensively. After 5 days of hospitalization, the dog died despite oxygen supplementation and anticoagulant therapy. This dog was diagnosed as unclassified interstitial lung disease based on histopathological findings.

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Bronchiolitis Obliterans with Organizing Pneumonia in a Dog

Cited by 8 publications

References 19 publications

Steroid‐responsive idiopathic interstitial lung disease in two dogs

Steroid‐responsive idiopathic interstitial lung disease in two dogs

Characterization of Severe Small Airway Disease in a Puppy Using Computed Tomography

Pulmonary hypertension due to unclassified interstitial lung disease in a Pembroke Welsh corgi

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