Bronchiolitis

Dalziel, Stuart R; Haskell, Libby; O’Brien, Sharon; Borland, Meredith L; Plint, Amy C.; Babl, Franz E; Oakley, Ed

doi:10.1016/s0140-6736(22)01016-9

Cited by 92 publications

(85 citation statements)

References 127 publications

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“…Fever and WBC count both represent the inflammatory reaction of the body. The clinical manifestations of bronchiolitis include cough, wheezing and fever ( 1 ). Prolonged fever indicates that patients are suffering from severe disease with a long course.…”

Section: Discussionmentioning

confidence: 99%

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A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis

et al. 2022

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ObjectivesPrediction of the efficacy of continuous positive airway pressure (CPAP) on bronchiolitis is necessary for timely treatment. This study aims to establish a nomogram for efficacy of CPAP on bronchiolitis, and compares accuracy with Pediatric Risk of Mortality III (PRISM III), Brighton Pediatric Early Warning Score (Brighton PEWS) and Pediatric Critical Illness Score (PCIS).MethodsFrom February 2014 to December 2020, data on children diagnosed with bronchiolitis and treated with CPAP in Chongqing was collected. The nomogram was evaluated by using multivariate logistic regression analysis. We compared the predictive value of model with PRISM III, PEWS and PCIS.ResultsA total of 510 children were included. The nomogram prediction model including fever, APTT, white blood cells, serum potassium concentration, lactic acid, immunodeficiency, atelectasis, lung consolidation, congenital airway dysplasia and congenital heart disease was established. The AUC of the nomogram was 0.919 in the training set and 0.947 in the validating set. The model fitted well, as evidenced by the calibration curve and Hosmer-Lemeshow goodness-of-fit test. We discovered that the nomogram significantly performed better than PRISM III, PCIS and PEWS.ConclusionsA nomogram including ten factors for predicting the efficacy of CPAP on bronchiolitis was established. It had higher performance than the PRISM III, PCIS, and PEWS in terms of clinical benefits.

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Section: Discussionmentioning

confidence: 99%

“…Bronchiolitis is a respiratory disease specific to children under 2 years old, which peaks in the fall and winter ( 1 ). It is a major cause of illness and hospitalization in infants and children.…”

Section: Introductionmentioning

confidence: 99%

A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis

et al. 2022

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“…Acute bronchiolitis is an acute infection of the lower respiratory tract resulting in obstruction or dyspnea, with major symptoms including cough, runny nose, paroxysmal wheezing, and in severe cases, hypoxemia, which affects infants and children worldwide ( Dalziel et al, 2022 ). It is most often caused by human respiratory syncytial virus (RSV) and the lung epithelium and alveolar macrophages are the first cells to be infected during RSV infection ( Blanco et al, 2002 ).…”

Section: Ferroptosis and Infectious Airway Inflammatory Diseasesmentioning

confidence: 99%

The link between ferroptosis and airway inflammatory diseases: A novel target for treatment

Lin

Yang

Guan

et al. 2022

Front. Mol. Biosci.

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Ferroptosis is an iron-dependent mode of cell death characterized by intracellular lipid peroxide accumulation and a redox reaction imbalance. Compared with other modes of cell death, ferroptosis has specific biological and morphological features. The iron-dependent lipid peroxidation accumulation is manifested explicitly in the abnormal metabolism of intracellular lipid oxides catalyzed by excessive iron ions with the production of many reactive oxygen species and over-oxidization of polyunsaturated fatty acids. Recent studies have shown that various diseases, which include intestinal diseases and cancer, are associated with ferroptosis, but few studies are related to airway inflammatory diseases. This review provides a comprehensive analysis of the primary damage mechanisms of ferroptosis and summarizes the relationship between ferroptosis and airway inflammatory diseases. In addition to common acute and chronic airway inflammatory diseases, we also focus on the progress of research on COVID-19 in relation to ferroptosis. New therapeutic approaches and current issues to be addressed in the treatment of inflammatory airway diseases using ferroptosis are further proposed.

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“…Acute viral bronchiolitis is one of the leading causes of hospitalization in the first 12–24 months of life ( 8 ). Airway cleansing, oxygen support and rehydration represent the main strategy suggested by international guidelines to manage viral bronchiolitis ( 9 ). As recent studies describe different phenotype corresponding to specific endotypes, trial with bronchodilator has been proposed in children with phenotype of bronchiolitis more strongly associated with asthma features.…”

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confidence: 99%