Bronchoalveolar Lavage Cellular Analysis and Gallium Lung Scan in the Assessment of Patients with Amiodarone-Induced Pneumonitis

Xaubet, Antoni; Roca, Josep; Rodríguez-Roisin, Roberto; Herránz, Jesús; Marín, A.; Lomeña, Francisco; Montserrat, J.M.; Agustí-Vidal, A

doi:10.1159/000195336

Cited by 22 publications

(11 citation statements)

References 14 publications

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“…The quantified lung activity was then compared to the hepatic activity and a lung-hepatic index (LHI) obtained. The uptake of gallium-67 in the pulmonary parenchyma was considered abnormally elevated when the LHI was higher than 0.25 [27].…”

Section: Ga 67 Lung Scanningmentioning

confidence: 99%

Clinical and functional assessment of patients with idiopathic pulmonary fibrosis: results of a 3 year follow-up

Agustı́¹,

Xaubet²,

Agustí³

et al. 1994

Eur Respir J

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The purpose of this study was to analyse the information provided by different techniques used in the assessment of patients with idiopathic pulmonary fibrosis (IPF) and their role in the prediction of lung function decline with the decline. Twenty seven subjects with IPF (55 +/- 14 (mean +/- SD) yrs) were studied at the initial staging. Nineteen of them (70%) were included in a follow-up over 3 yrs (32 +/- 6 months), whilst the remaining 8 patients were lost to follow-up. During the period of the study, 6 of the 19 patients died. A significant correlation between diffusing capacity of the lungs for carbon monoxide (DLCO) (and carbon monoxide transfer coefficient (KCO) = DLCO/alveolar volume (VA)) and the increase in alveolar-arterial oxygen tension difference (A-aPO2) during exercise (delta A-aPO2) was observed at diagnosis (r = -0.58). Despite the treatment with prednisone (1 mg.kg-1 daily during 4 weeks, tapered to an individualized maintenance daily dose of 15-30 mg), the 13 patients controlled throughout the whole period of the study showed a marked impairment in lung volumes; forced vital capacity (FVC) -0.46 +/- 0.09 l, from 69 +/- 16 to 52 +/- 11% of predicted, and total lung capacity (TLC) -0.39 +/- 0.11 l, from 75 +/- 16 to 62 +/- 14%, and in DLCO -0.6 +/- 0.2 mmol.min-1.kPa-1, from 56 +/- 15 to 47 +/- 18%, predicted. By contrast, both mean arterial oxygen tension (PaO2) and A-aPO2 at rest remained unchanged throughout the 3 yrs follow-up.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Ga 67 Lung Scanningmentioning

confidence: 99%

Clinical and functional assessment of patients with idiopathic pulmonary fibrosis: results of a 3 year follow-up

Agustı́¹,

Xaubet²,

Agustí³

et al. 1994

Eur Respir J

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“…Gallium scanning has been used extensively in the staging of interstitial lung disease (Keogh et al 1983;Klech Offprint requests to: M. Yeates, Department of Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia * This work was supported in part by the Australian NH&MRC et al 1987;Xaubet et al 1987;Gibson et al 1988;Pantin et al 1988;Sfakianikas et al 1988;Breit et al 1989) with quantitation of the degree of pulmonary gallium uptake being shown to be useful in some studies (Bisson etal. 1983(Bisson etal.…”

Section: Introductionmentioning

confidence: 99%

Quantitative pulmonary gallium scanning in interstitial lung disease

et al. 1992

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The mechanisms responsible for gallium uptake in chronic, non-infective, diffuse lung disease are not completely understood. This study attempted to clarify some of them. A lung/liver gallium index was calculated in 113 subjects, some normal and some with various interstitial lung diseases, predominantly those associated with connective tissue disease. The mean gallium index was significantly higher in the groups with active interstitial lung disease (5.7) and non-infective bronchiolitis (4.1) compared with non-smoking normals (3.0; P less than 0.05). To investigate the mechanisms responsible for gallium uptake, the gallium index was correlated with bronchoalveolar lavage findings, respiratory function tests and clinical features. Significant correlations (P less than 0.05) were found with age in non-smoking normals; lavage macrophages in smoking normals; age but no other parameter in bronchiolitis; lavage lymphocytes, lavage albumin and improvement in diffusion capacity for carbon monoxide in those with active interstitial lung disease. It is concluded that in normal smokers gallium uptake may be due to a macrophage-mediated process. Gallium uptake in active interstitial lung disease associated with connective tissue disease appears to be an immunological process in which transport and retention of gallium is associated with that of albumin.

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“…The BAL in patients with APT can show an increase in the number of neutrophils, CD8 ϩ lymphocytes and the presence of foamy cells with lamellar inclusions. 17 Biopsy findings include septal thickening, interstitial edema and lipids within endothelial cells and the interstitium. 18,19 Other pathologic findings include acute organizing pneumonia, Type II cell hyperplasia and free foamy intra-alveolar macrophages.…”

Section: Discussionmentioning

confidence: 99%