Bronchoalveolar lavage in drug-induced lung disease

Costabel, Ulrich; Uzaslan, Esra; Guzman, Josune

doi:10.1016/s0272-5231(03)00143-6

Cited by 104 publications

(55 citation statements)

References 63 publications

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“…Bronchoalveolar lavage in drug-induced pneumonitis may present any type of alveolitis (lymphocytic, neutrophilic, eosinophilic or mixed) or diffuse alveolar haemorrhage. The most frequent finding is a lymphocytic alveolitis with the predominance of CD8+ cells, just as in hypersensitivity pneumonitis [20].…”

Section: Discussionmentioning

confidence: 98%

Hypersensitivity pneumonitis associated with the use of temozolomide

Koschel¹,

Handzhiev²,

Leucht³

et al. 2009

Eur Respir J

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The aim of the present study was to investigate a case of hypersensitivity pneumonitis associated with the use of temozolomide in the treatment of gliosarcoma.A 54-yr-old female developed dyspnoea, cough and hypoxia after surgical resection for gliosarcoma and adjuvant radio-and chemotherapy with temozolomide. A high-resolution computed tomography scan of the thorax showed a bilateral ground-glass pattern. Bronchoscopy with bronchoalveolar lavage and lung biopsies was performed.Bronchoalveolar lavage demonstrated significant lymphocytic alveolitis and transbronchial lung biopsies revealed lymphocytic infiltration with foamy macrophages, consistent with hypersensitivity pneumonitis. There was no evidence of other causes, including infections. After withdrawing temozolomide and initiating prednisolone therapy, the patient had no further pulmonary symptoms.To the present authors' knowledge, this is the first definitively described case of temozolomideassociated hypersensitivity pneumonitis.

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Section: Discussionmentioning

confidence: 98%

Hypersensitivity pneumonitis associated with the use of temozolomide

Koschel¹,

Handzhiev²,

Leucht³

et al. 2009

Eur Respir J

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“…Bronchoalveolar lavage findings may support the likelihood of certain lung diseases; however, the information is not specific, and in order to obtain a definitive diagnosis, further investigations are required [13, 14]. In drug-associated pneumonitis, a predominantly lymphocytic fluid is the most common finding in the bronchoalveolar lavage, but there are cases with normal cell differential [15].…”

Section: Discussionmentioning

confidence: 99%

Rituximab-Induced Hypersensitivity Pneumonitis

et al. 2008

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Rituximab is a chimeric anti-CD20 monoclonal antibody used to treat CD20+ non-Hodgkin’s lymphoma. Although pulmonary adverse reactions such as cough, rhinitis, bronchospasm, dyspnea and sinusitis are relatively common, other respiratory conditions like cryptogenic organizing pneumonia, interstitial pneumonitis and diffuse alveolar hemorrhage have rarely been reported. Only 2 possible cases of rituximab-associated hypersensitivity pneumonitis have been described to date. We present a case of hypersensitivity pneumonitis with classic radiographic and histopathologic findings in a patient treated with rituximab who responded to prednisone.

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“…On the other hand that is elevated for CHP and sarcoidosis (34). In BALF eosinophilia, eosinophilic pneumonia or drug associated ILD is possible (35). BALF analyses have some limitations.…”

Section: Bronchoalveolar Lavage (Bal)mentioning

confidence: 99%

Staging of idiopathic pulmonary fibrosis

Kishaba¹

2017

Int j curr adv res

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Bronchoalveolar lavage in drug-induced lung disease

Cited by 104 publications

References 63 publications

Hypersensitivity pneumonitis associated with the use of temozolomide

Hypersensitivity pneumonitis associated with the use of temozolomide

Rituximab-Induced Hypersensitivity Pneumonitis

Staging of idiopathic pulmonary fibrosis

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