Bronchoalveolar Lymphocytosis in Patients with Tropical Spastic Paraparesis Associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)

Couderc, Louis Jean; Caubarrere, I.; Venet, Alain; Magdeleine, J.; Jouanelle, A.; Danon, F; Buisson, G; Vernant, Jean‐Claude

doi:10.7326/0003-4819-109-8-625

Cited by 50 publications

(29 citation statements)

References 18 publications

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“…Recent studies have also linked HTLV-I infec tion to a variety of inflammatory diseases such as arthritis (4,5), broncho-alveolitis (6), and Sjogren's syndrome (7,8). Previous epidemiologic studies also have shown that HTLV-I is associated closely with polymyositis (9,10).…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte Subsets in Muscle Biopsies of Human T-Lymphotropic Virus Type I Carriers with Polymyositis.

et al. 1992

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Recent epidemiologic studies have shown that human T-lymphotropic virus type I (HTLV-I) is associated with polymyositis. To clarify the histological features of HTLV-I positive polymyositis, we studied muscle tissue from two groups of patients with polymyositis, those seropositive for HTLV-I (5 patients) and those seronegative (5 patients). We examined the lymphocyte subsets in muscle biopsies using monoclonal antibodies. In the endomysium, a variable number of T-lymphocytes and macrophages and a smaller proportion of B-lymphocytes were found in both groups. In both HTLV-I positive and negative patients a variable number of T-lymphocytes and macrophages, with a smaller number of B-lymphocytes, were found in the perimysium. As a whole, the T-lymphocytes were predominantly of the helper/inducer phenotype in both groups. We failed to find any specific phenotype distribution among T-cells infiltrating the muscle of HTLV-I carriers with polymyositis. (Internal Medicine 31: 973-977, 1992)

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Section: Introductionmentioning

confidence: 99%

Lymphocyte Subsets in Muscle Biopsies of Human T-Lymphotropic Virus Type I Carriers with Polymyositis.

et al. 1992

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“…The mechanism by which spinal cord degeneration is caused by HTLV-I infection is considered to be immunologic (8,9). The association of Graves' disease with HAM is not incidental, because the incidence of manyother autoimmunediseases or immune-mediated diseases are high in HAM patients or HTLV-I carriers (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Development of Graves' Ophthalmopathy and Uveitis after Radioiodine Therapy for Graves' Disease in a Patient with HTLV-I Associated Myelopathy (HAM).

et al. 1994

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HTLV-I carriers or patients with HTLV-I associated myelopathy (HAM)are prone to immune-mediated inflammatory disorders. Wepresent a 44-year-old female with HAMwho developed Graves' disease. She developed severe Graves' ophthalmopathy shortly after 131I therapy, concurrently with a remarkable increase in TSH-receptor antibody titer. Ophthalmopathy was aggravated in spite of prednisolone therapy and euthyroidism being maintained by thyroxine replacement. Uveitis also developed after 131I therapy and iridocyclitis finally required trabeculotomy. This case suggests that HAM patients may have a higher risk of immune-mediated Graves' ophthalmopathy after 131I therapy. (Internal Medicine 33: 564-568, 1994)

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“…In the first paper that identified pulmonary involvement in patients with HAM in South America 8 , we showed that seven of eight patients had lymphocytosis in the bronchoalveolar fluid. Sugimoto et al described T-lymphocytosis in the BAL fluid of 80% of the 15 patients with HAM in Japan 13,14 and Couderc et al 1 reported 76% of T-lymphocyte alveolitis of the 21 patients from Africa. These findings indicate that the lung represents an important organ in the pathogenesis of HAM.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that patients with HTLV-I associated myelopathy (HAM) are frequently associated with vasculitis, ichtiosis, Sjogren syndrome, and other immunological diseases 3,4,6 . Gessain et al 2 have reported evidence of pulmonary involvement in patients with HAM and subsequently several authors described lymphocytosis in the bronchoalveolar lavage (BAL) fluid of patients with HAM 1,8,13 . The proliferation of peripheral blood mononuclear cells (PBMC), production of interleukin-2 (IL-2), polyclonal Federal University of Bahia (UFBA).…”

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confidence: 99%

Pulmonary involvement in patients with HTLV-I associated myelopathy

Mattos

Melo

Publio

et al. 1995

Arq. Neuro-Psiquiatr.

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Pulmonary involvement in HTLV-I patients has been identified by several authors in Africa, Japan and Brazil. The objective of this controlled study is to establish an association between HAM and lymphocytosis in the bronchoalveolar fluid (BAL). Thirty-five adult patients with non-traumatic and non-tumoral myelopathy filled out a detailed historical survey and underwent a neurological examination, a thoracic radiological evaluation and a CSF examination. Of the patients in this sample, 22 were diagnosed with HTLV-I associated myelopathy and 13 had myelopathies with other etiologies. Lymphocytosis in the BAL fluid was detected in 18 (82%) of the HAM patients and in 2 (15%) of non-HAM patients. We concluded that the lung represents an important organ in the pathogenesis of HAM.

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Bronchoalveolar Lymphocytosis in Patients with Tropical Spastic Paraparesis Associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)

Abstract: Excessive absolute numbers and percentages of alveolar lymphocytes were observed in 18 and 16 patients, respectively. Most alveolar lymphocytes were CD8+ cells.

Cited by 50 publications

References 18 publications

Lymphocyte Subsets in Muscle Biopsies of Human T-Lymphotropic Virus Type I Carriers with Polymyositis.

Lymphocyte Subsets in Muscle Biopsies of Human T-Lymphotropic Virus Type I Carriers with Polymyositis.

Development of Graves' Ophthalmopathy and Uveitis after Radioiodine Therapy for Graves' Disease in a Patient with HTLV-I Associated Myelopathy (HAM).

Pulmonary involvement in patients with HTLV-I associated myelopathy

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