Bronchodilator and antiallergy activity of forskolin

Kreutner, William; Chapman, Richard W.; Gulbenkian, A.; Tozzi, Salvatore

doi:10.1016/0014-2999(85)90106-2

Cited by 29 publications

(20 citation statements)

References 18 publications

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“…A similar observation has been made for forskolin. 23 In view of these data, our finding that AA 861 had no effect on bronchoconstriction, while almost abolishing leukotriene production, supports the prevailing notion that leukotrienes have little significance in early anaphylactic bronchoconstriction in the rat. 24,25 In conclusion, all cAMP mediated drugs reduced antigen induced bronchoconstriction and the production of eicosanoids in isolated rat lungs.…”

Section: Introductionsupporting

confidence: 74%

Cyclic‐AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

Post¹,

Biesebeek

Wemer³

et al. 1992

Mediators of Inflammation

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Section: Introductionsupporting

confidence: 74%

Cyclic‐AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

Post¹,

Biesebeek

Wemer³

et al. 1992

Mediators of Inflammation

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“…Therefore, these drugs dramatically inhibit PCA and, in our study, potent dose-dependent inhibitions were observed in the histamine-, serotonin-and LTC4-induced cutaneous reactions. Since similar effects have been obtained with forskolin [32,33] which activates adenyl cyclase to increase the intracellular cyclic AMP level despite the lack of action on (3 receptors [34], a drug which increases intracellular cyclic AMP may not only reduce the release of mediators but also unspecifically inhibit the reactions induced by the re leased mediators [34], From the results obtained here, we think that we can evaluate the properties of anti-allergic drugs rather easily using a method in which PCA and me diator-induced cutaneous reactions are induced simultaneously and the effects of a drug on these reactions are determined.…”

Section: Discussionmentioning

confidence: 50%

A Method for Evaluating Anti-Allergic Drugs by Simultaneously Induced Passive Cutaneous Anaphylaxis and Mediator Cutaneous Reactions

Koda

Miura

Inagaki

et al. 1990

Int Arch Allergy Immunol

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Homologous passive cutaneous anaphylaxis (PCA) was induced by IgE antibody and, simultaneously, cutaneous reactions were induced by some allergic mediators such as histamine, serotonin and leukotriene (LT) C₄ on rat back skin. Disodium cromoglycate and tranilast with inhibitory actions on mediator release inhibited PCA specifically, whereas antihistaminics, including ketotifen, azelastine, mequitazine and diphenhydramine, inhibited histamine- and serotonin-induced cutaneous reactions as well as PCA. Anti-slow-reacting substance of anaphylaxis drugs, KC-404 and FPL-55712, significantly inhibited PCA and histamine-and serotonin-induced reactions, but at the same doses they did not produce significant inhibition of the LTC₄-induced reaction. All reactions tested were strongly inhibited dose dependently with the β stimulants, salbutamol and isoproterenol, and a xanthine derivative, theophylline, which are known to increase the intra-cellular cyclic AMP level. We think that this method enables the determination of the properties of anti-allergic drugs.

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“…The allergen-induced release of these mediators is af fected by agents that increase the intracellular con centration of cAMP [4,11,12]. Inhibitors of arachidonic acid generation or metabolism block histamine release as well as LTC4 generation [13][14][15], although AA-861, a selective 5-lipoxygenase inhibitor, failed to inhibit histamine release from human basophils and human lung tissues [16], In addition, indomethacin, a cyclooxygenase inhibitor, produces an enhancement of both histamine release and LTC4 generation from allergen-challenged human basophils [2,17].…”

Section: Discussionmentioning

confidence: 99%

Effect of Deuterium Oxide on Leukotriene C<sub>4</sub> Generation in Immunologically Stimulated Human Leukocytes

Mita¹,

Yui²,

Yasueda³

et al. 1988

Int Arch Allergy Immunol

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Addition of deuterium oxide (D₂O), 6–36%, resulted in a dose-dependent increase in allergen- or anti-IgE-induced leukotriene C₄ (LTC₄) generation from human basophils. In the presence of 36% D₂O, the enhancement was 260 ± 135% for allergen stimulation and 480 ± 152% for anti-IgE stimulation as compared with the control incubated in normal buffer. The increasing effect of D₂O on LTC₄ generation from basophils was completely reversed by washing the cells before incubation with allergen. Vinblastine as well as colchicine, at a concentration of 100 μM, counteracted the effect of D₂O. The enhanced release of histamine and LTC₄ from basophils challenged with allergen was suppressed by Dimaprit, a histamine H₂ receptor agonist, at a concentration required to inhibit the release by 50% of 5 × 10^––5M for histamine and 10^––5M for LTC₄. These observations suggest that microtubules may be involved in LTC₄ generation from immunologically stimulated basophils.

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Bronchodilator and antiallergy activity of forskolin

Cited by 29 publications

References 18 publications

Cyclic‐AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

Cyclic‐AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

A Method for Evaluating Anti-Allergic Drugs by Simultaneously Induced Passive Cutaneous Anaphylaxis and Mediator Cutaneous Reactions

Effect of Deuterium Oxide on Leukotriene C<sub>4</sub> Generation in Immunologically Stimulated Human Leukocytes

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