Bronchodilator Effect of Infused B-Type Natriuretic Peptide in Asthma

Relaxant effect of brain natriuretic peptide in nonsensitized and passively sensitized isolated human bronchi

“…We completely agree with Candenas et al [30] and Labat et al [31], who suggested that there are no receptors for BNP on human airway smooth muscle and, consequently the We must highlight that we have used isolated bronchi from non atopic patients undergoing surgery because of lung cancer, whereas human recombinant BNP (nesiritide) is a potent bronchodilator in asthmatic patients [29]. These findings fit with the observation of Ohbayashi et al [20], who reported that ANP and BNP failed to relax guinea pig airways but both peptides inhibited antigen-induced bronchoconstriction in sensitized animals, suggesting that natriuretic peptide receptors might be expressed on airway smooth muscle during an inflammatory process.…”

“…In particular, there is documentation that ANP produces significant bronchodilation when given intravenously to both normal [27] and asthmatic subjects [13] and by inhalation in high doses in asthmatics [28]. Moreover, recently it has been documented that human recombinant BNP (nesiritide) is a potent bronchodilator in asthmatic patients [29].…”

Preserved pulmonary vasodilative properties of aerosolized brain natriuretic peptide

“…However, as stated above obstructive lung diseases may also be a target for the use of cGMP enhancing therapies, such as BNP aerosol. For example, in a recent study, the infusion of recombinant BNP (neseritide) led to a significant alleviation of pulmonary obstruction in asthmatic patients [25].…”

Pharmacology and Therapeutics of Bronchodilators

“…The incubation of human ASM with BNP can elicit a significant reduction of cholinergic and histaminergic responses (Matera et al, 2011a). We speculate that the direct activation of the natriuretic peptide receptor-A might influence bronchial tone, inducing bronchodilation, and certainly it has been documented that human recombinant BNP (nesiritide) is a potent bronchodilator in patients with asthma (Akerman et al, 2006).…”