Bronchodilator responsiveness in patients with chronic heart failure

Minasian, Armine G.; Elshout, Frank J.J. van den; Dekhuijzen, P.N.R.; Vos, Petra J.E.; Willems, Frank F.; Bergh, Paul J.P.C. van den; Heijdra, Yvonne F.

doi:10.1016/j.hrtlng.2012.11.007

Cited by 24 publications

(14 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After administration of bronchodilators (400 µg of salbutamol and 80 µg of ipratropium), FEV 1 and the FEV 1 /FVC ratio, but not the FVC, increased slightly but significantly: pre‐ vs. post‐bronchodilator FEV 1 /FVC 0.68 ± 0.8 vs. 0.71 ± 0.8, P <0.001. In 22%, post‐bronchodilator FEV 1 /FVC values increased to >0.7, thus reducing the percentage of patients with obstruction to 33% . Patients with HFrEF and clinical signs of pulmonary congestion ( n = 16) more often had a FEV 1 /FVC <0.7 after bronchodilation than the remaining 100 HF patients without such signs (56% vs. 30%, P = 0.04) .…”

Section: Reversibility Testing In Patients With Heart Failurementioning

confidence: 99%

“…Differences in these rates may be due to numerous factors such as geographical region, age and sex distribution, urban environment, and smoking prevalence of the study population, but importantly also depend on the diagnostic criteria and definition of COPD applied, and whether patients underwent spirometry while in a euvolaemic and stable condition of HF . Surprisingly, only a few studies included spirometry to determine the presence of COPD ( Table ) . Most studies relied rather on medical recordings or patients self‐report to diagnose COPD .…”

Section: Prevalence Of Chronic Obstructive Pulmonary Disease In Patiementioning

confidence: 99%

“…An increase of >12% or >200 mL in the baseline FEV 1 after inhalation of a bronchodilator (usually a beta‐2‐agonist) is an accepted positive bronchodilator response indicating reversibility of obstruction . A recent study conducted in 116 patients with stable chronic HFrEF and no history of asthma or COPD detected a pre‐bronchodilator airway obstruction in 55% . After administration of bronchodilators (400 µg of salbutamol and 80 µg of ipratropium), FEV 1 and the FEV 1 /FVC ratio, but not the FVC, increased slightly but significantly: pre‐ vs. post‐bronchodilator FEV 1 /FVC 0.68 ± 0.8 vs. 0.71 ± 0.8, P <0.001.…”

Section: Reversibility Testing In Patients With Heart Failurementioning

confidence: 99%

See 2 more Smart Citations

Chronic obstructive pulmonary disease in heart failure: accurate diagnosis and treatment

Güder

Brenner

Störk

et al. 2014

European J of Heart Fail

View full text Add to dashboard Cite

Coincidence of COPD and heart failure (HF) is challenging as both diseases interact on multiple levels with each other, and thus impact significantly on diagnosis, disease severity classification, and choice of medical therapy. The current overview aims to educate caregivers involved in the daily management of patients with HF and (possibly) concurrent COPD in how to deal with clinically relevant issues such as interpreting spirometry, the potential role of extensive pulmonary function testing, and finally, the potential beneficial, but also detrimental effects of medication used for HF and COPD on either disease.

show abstract

Section: Reversibility Testing In Patients With Heart Failurementioning

confidence: 99%

Section: Prevalence Of Chronic Obstructive Pulmonary Disease In Patiementioning

confidence: 99%

Section: Reversibility Testing In Patients With Heart Failurementioning

confidence: 99%

See 1 more Smart Citation

Chronic obstructive pulmonary disease in heart failure: accurate diagnosis and treatment

Güder

Brenner

Störk

et al. 2014

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

“…[8][9][10][11][12] Moreover, pulmonary function impairment increases with the severity of heart failure, 9,11 provides important prognostic information, [39][40][41][42] and may ameliorate or normalize with several treatment modalities, such as pharmacologic and nonpharmacologic treatment of heart failure 2,28,43-46 and antiobstructive therapy with bronchodilators. [47][48][49][50][51][52][53] Pulmonary function might thus be used as a guide for the evaluation of patients with chronic heart failure, with respect to severity of disease, prognosis, and response to treatment.…”

Section: Discussionmentioning

confidence: 99%

Using the Lower Limit of Normal Instead of the Conventional Cutoff Values to Define Predictors of Pulmonary Function Impairment in Subjects With Chronic Heart Failure

Minasian¹,

Elshout²,

Dekhuijzen

et al. 2015

Respir Care

View full text Add to dashboard Cite

BACKGROUND: Using the newer lower limit of normal criterion instead of the conventional cutoff values to define pulmonary function abnormalities may result in different predictors of pulmonary function impairment in patients with heart failure. Therefore, we assessed predictors of pulmonary function impairment in subjects with chronic heart failure according to the lower limit of normal in comparison with conventional cutoff values. METHODS: In this prospective cross-sectional study, 164 chronic heart failure subjects (age 68 ؎ 10 y, 78% men, 88% New York Heart Association class I-II) with left ventricular ejection fraction <40% underwent pulmonary function tests. Predictors of pulmonary function impairment were assessed using the lower limit of normal and conventional cutoff values (ie, 80% predicted value and the fixed ratio of FEV 1 /FVC <0.7). RESULTS: The lower limit of normal criterion identified an extra independent predictor of diffusion impairment compared with the 80% predicted value; in addition to body mass index, pack-years, and alveolar volume, female sex also turned out to be an independent predictor. A smoking history of >10 pack-years was a significant predictor of diffusion impairment and airway obstruction using the lower limit of normal criterion but not using the conventional cutoff values. However, lowering the cutoff points of conventional criteria to match the more stringent lower limit of normal and thus avoid overdiagnosis of diffusion impairment and airway obstruction in the elderly produced similar results as the lower limit of normal. CONCLUSIONS: The lower limit of normal identifies more predictors of diffusion impairment and airway obstruction compared with conventional cutoff values in subjects with chronic heart failure with left ventricular systolic dysfunction. However, lowering the conventional cutoff points yielded similar results as the lower limit of normal. (ClinicalTrials.gov registration NCT01429376.) Key words: Chronic heart failure, conventional cutoff values, lower limit of normal, predictors, pulmonary function impairment. [Respir Care 2016;61(2):173-183.

show abstract

“…1 The authors aimed to evaluate the effect of inhaled bronchodilators on pulmonary function and dyspnea in patients with chronic heart failure (HF). They concluded that inhaled bronchodilators have the potential to improve pulmonary function in patients with chronic HF, especially in those with airway obstruction.…”

mentioning

confidence: 99%

Heart failure: Not only reduced left ventricular ejection fraction but also reserved ejection fraction!

et al. 2013

View full text Add to dashboard Cite

Bronchodilator responsiveness in patients with chronic heart failure

Cited by 24 publications

References 28 publications

Chronic obstructive pulmonary disease in heart failure: accurate diagnosis and treatment

Chronic obstructive pulmonary disease in heart failure: accurate diagnosis and treatment

Using the Lower Limit of Normal Instead of the Conventional Cutoff Values to Define Predictors of Pulmonary Function Impairment in Subjects With Chronic Heart Failure

Heart failure: Not only reduced left ventricular ejection fraction but also reserved ejection fraction!

Contact Info

Product

Resources

About