Bronchogenic Squamous Cell Carcinoma Presenting as Cicatrizing Conjunctivitis

Vroman, David T; Breckenridge, Rebecca Reid; Solomon, Kerry D.; Sandoval, Hugo; Castro, Luis E. Fernández de

doi:10.1097/01.ico.0000196447.79817.ce

Cited by 4 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a similar reported case of paraneoplastic pemphigoid, the diagnosis of squamous cell lung cancer was made 2 months after the patient developed cicatrising conjunctivitis 7. The differential diagnosis for cicatrising conjunctivitis is broad and includes OCP, Stevens Johnsons syndrome, chemical burns, radiation, toxic conjunctivitis, post-infectious conjunctivitis, graft versus host disease, atopic keratoconjunctivitis and conjunctival squamous cell carcinoma 1.…”

Section: Commentmentioning

confidence: 99%

Cicatrising conjunctivitis due to paraneoplastic pemphigoid

Rutar

Chan

Acharya

et al. 2007

British Journal of Ophthalmology

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 99%

Cicatrising conjunctivitis due to paraneoplastic pemphigoid

Rutar

Chan

Acharya

et al. 2007

British Journal of Ophthalmology

View full text Add to dashboard Cite

“…Drugs or medication such as beta(2)-adrenergic agonists and anticholinergic agents, glucocorticoids, phenothiazines, antirheumatic drugs such as quinolines, and allopurinol, psychiatric drugs such as phenothiazine, and chlorpromazine; cardiovascular drugs such as practolol, and amiodarone can also cause ocular inflammatory diseases [11–12]. Also, certain cancers such as lymphoma [58, 59], lung cancer [60] and breast cancer [13, 61] can cause ocular inflammatory diseases [14]. …”

Section: Introductionmentioning

confidence: 99%

Understanding the Role of Aldose Reductase in Ocular Inflammation

Yadav¹,

Srivastava²,

Ramana³

2010

CMM

View full text Add to dashboard Cite

Aldose reductase, although identified initially as a glucose-reducing enzyme via polyol pathway, is believed to be an important component of antioxidant defense system as well as a key mediator of oxidative stress-induced molecular signaling. The dual role played by AR has made it a very important enzyme for the regulation of not only the cellular redox state by detoxifying the reactive lipid-aldehydes generated by lipid peroxidation which is crucial in the cellular homeostasis, but also in the regulation of molecular signaling cascade that may regulate oxidative stress-induced cytotoxic events. Search for the new molecular targets to restrain the oxidative stress-induced inflammation has resulted in the identification of AR as an unanticipated mediator of oxidative stress-induced signaling. Although, in last one decade or so AR has been implicated in various inflammation-related disease conditions ranging from diabetes, sepsis, cancer, cardiovascular and airway inflammation, however, a critical evaluation of the clinical efficacy of AR inhibitors awaits a better understanding of the role of AR in regulating inflammation, especially in ocular inflammation.

show abstract