Bronchopulmonary Aspergillosis: Diagnostic and Therapeutic Considerations

Ikemoto, Hideo

doi:10.1007/978-1-4612-2762-5_3

Cited by 6 publications

(5 citation statements)

References 122 publications

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“…The deep pit or groove of abnormal crown morphology, where saliva, food remnants and bacteria are trapped, make DI teeth susceptible to caries ( 23 , 24 ). If the enamel lining the surface of the invagination is naturally absent or destroyed by caries, bacteria and their products can diffuse to the pulp, leading to pulpitis and periapical periodontitis ( 13 , 25 ). Therefore, early and correct diagnosis of DI is especially important to implement appropriate prevention or treatment strategies for DI.…”

Section: Discussionmentioning

confidence: 99%

Treatment opinions for dens invaginatus: A case series

Wei,

Wang,

Shen

et al. 2024

Exp Ther Med

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Dens invaginatus (DI) is a rare congenital dental malformation characterized by enamel or cementum folded into dentine. Such teeth are susceptible to caries, pulp infection or necrosis and periradicular lesion. The complex anatomy of this disease results in difficult treatment and a high rate of therapeutic failure. Therapeutic options, such as debriding and filling invagination, root canal treatment (RCT) and intentional replantation, vary according to the morphology and infection of the involved tooth. The present study reports five cases of DI with chronic apical periodontitis. The treatment strategies and procedures, including RCT, removing the invagination, intentional replantation and surgical treatment, are discussed according to the classification and the condition of pulp and periapical tissue. The study also reports the prognosis: All patients were followed up for ≥12 months and all teeth demonstrated periapical healing and clinical asymptomatic. In summary, appropriate treatment is based on accurate analysis of the anatomical variation in different types of DI and intentional replantation is a reliable and viable treatment to preserve the tooth.

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Section: Discussionmentioning

confidence: 99%

Treatment opinions for dens invaginatus: A case series

Wei,

Wang,

Shen

et al. 2024

Exp Ther Med

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“…Spontaneous lysis of the fungus ball has been reported in approximately 7% to 10% of patients with pulmonary aspergilloma [18][19][20] and it is therefore difficult to evaluate the efficacy of either intracavitary instillation of antifungals or systemic antifungals. Our data suggest that, during ITCZ treatment, ITCZ may be excreted to sputa.…”

Section: Discussionmentioning

confidence: 99%

Aspergilloma: comparison of treatment methods and prognoses

Mori

Ebe

Isonuma

et al. 2000

Journal of Infection and Chemotherapy

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“…Taking this phenomenon into account, the changes in immunoblot patterns were related to the clinical status, reaction to therapy and time. The value of monitoring Aspergillus-infected patients by measuring antibody responses is still under discussion [1,5,25]. In general, to evaluate antibody responses as a parameter of disease, patients need to have a functioning humoral im-mune system, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Although patients with Aspergillusinduced lung diseases have to be monitored carefully, no single tool is adequate to evaluate the clinical response to treatment. Since the presence of antibodies to Aspergillus is either a feature of or one of the criteria for the diagnosis of Aspergillus-induced lung diseases [1], changes in the levels of specific antibodies could be used to monitor disease activity. Immunodiffusion and enzyme-linked immunosorbent assay (ELISA) are the most widely used methods to detect antibodies to Aspergillus fumigatus (Af).…”

Section: Detection Of Immunoglobulins G and A To Aspergillus Fumigatumentioning

confidence: 99%

“…Inhalation of Aspergillus can result in similar antibody responses. Allergic bronchopulmonary aspergillosis (ABPA) is suggested to be more of a mucosal disease, whereas Aspergillus infection is more of a parenchymal disease, and thus the antibody response is different [1]. Assessment of total IgE and specific IgE antibodies has been successfully used to monitor patients with ABPA [12,13].…”

Section: Detection Of Immunoglobulins G and A To Aspergillus Fumigatumentioning

confidence: 99%

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Detection of immunoglobulins G and A to Aspergillus fumigatus by immunoblot analysis for monitoring Aspergillus-induced lung diseases

Rens

Vernooy-Jeras²,

Ridder³

et al. 1998

Eur Respir J

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The aim of the study was to investigate whether patients with Aspergillus-induced lung disease can be monitored by immunoblot analysis to detect antibodies to Aspergillus fumigatus (Af). Immunoblotting was performed by incubating 57 longitudinally collected sera from 13 patients on nitrocellulose sheets, blotted with Af antigen, separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Bound antibodies were demonstrated by peroxidase-labelled antihuman immunoglobulins (Ig)G and IgA antiserum and diaminobenzidine plus H2O2 as substrate. The immunoblot patterns were related to the patients' clinical status and time. Each patient had a characteristic immunoblot pattern that varied with time. There was a relationship between disease activity or clinical response and changes in immunoblot antibody patterns: a rise in anti-Af IgG and IgA antibodies was seen in sera collected during active disease, compared with before active disease, and a significant decline in anti-Af IgG and IgA was demonstrated in sera collected during recovery, compared with during active disease. Only in the acute stage of allergic bronchopulmonary aspergillosis were IgA antibodies against Af antigens of <20,000 Da demonstrated. Immunoblot analysis can be used to monitor the disease activity and the responses to treatment of patients with Aspergillus-induced lung diseases. Changes in specific immunoglobulin A may be more informative than specific immunoglobulin G.

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Bronchopulmonary Aspergillosis: Diagnostic and Therapeutic Considerations

Cited by 6 publications

References 122 publications

Treatment opinions for dens invaginatus: A case series

Treatment opinions for dens invaginatus: A case series

Aspergilloma: comparison of treatment methods and prognoses

Detection of immunoglobulins G and A to Aspergillus fumigatus by immunoblot analysis for monitoring Aspergillus-induced lung diseases

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