Bronchopulmonary dysplasia: Clinical presentation

Bancalari, Eduardo; Abdenour, George E.; Feller, Rosalyn; Gannon, J.

doi:10.1016/s0022-3476(79)80442-4

Cited by 454 publications

(191 citation statements)

References 11 publications

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“…Bronchopulmonary dysplasia (BPD) was defined as an oxygen requirement at 28 days of life and chronic radiographic changes. 13 Oxygen dependency at 36 weeks postmenstrual age was considered a separate diagnosis. The diagnosis of intraventricular hemorrhage (IVH) was made by cranial ultrasonography (this was carried out at least twice, in the first week of life, and at 3 to 4 weeks age) or by autopsy and was classified according to Papile et al 14 Periventricular leukomalacia (PVL) was diagnosed by the presence of focal echolucencies on the cranial ultrasound.…”

Section: Methodsmentioning

confidence: 99%

A New Score for Predicting Neonatal Very Low Birth Weight Mortality Risk in the NEOCOSUR South American Network

et al. 2005

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in infants with birth weight 500 to 1500 g were employed. A testing sample and crossvalidation techniques were used to validate a statistical model for risk of in-hospital mortality. The new risk score was compared with two existing scores by using area under the receiver operating characteristic curve (AUC). RESULTS:The new NEOCOSUR score was highly predictive for in-hospital mortality (AUC ¼ 0.85) and performed better than the Clinical Risk Index for Babies (CRIB) and the NICHD risk models when used in the NEOCOSUR Network. The new score is also well calibrated F it had good predictive capability for in-hospital mortality at all levels of risk (HL test ¼ 11.9, p ¼ 0.85). The new score also performed well when used to predict in hospital neurological and respiratory complications. CONCLUSIONS:A new and relatively simple VLBW mortality risk score had a good prediction performance in a South American network population. This is an important tool for comparison purposes among NICUs. This score may prove to be a better model for application in developing countries.

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Section: Methodsmentioning

confidence: 99%

A New Score for Predicting Neonatal Very Low Birth Weight Mortality Risk in the NEOCOSUR South American Network

et al. 2005

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“…Three widely used clinically validated definitions of BPD were included in the analysis: i) chronic supplemental oxygen needs for at least 28 days (BPD-28DAYS) 10 ; ii) chronic supplemental oxygen needs at either 36 weeks post menstrual age (PMA) or discharge home whichever came first (BPD-36WKS) 11 ; and iii) BPD as categorically defined (mild, moderate or severe) based on the NICHD consensus definition (BPD-NICHD). 8 In accordance with the NICHD consensus definitions "mild BPD" was defined as the need for supplemental oxygen for at least 28 days.…”

Section: Definitionsmentioning

confidence: 99%

Heritability of Bronchopulmonary Dysplasia, Defined According to the Consensus Statement of the National Institutes of Health

2008

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Objective-The goal was to determine the magnitude of genetic effects on susceptibility and risk factors for bronchopulmonary dysplasia by using the clinically validated National Institutes of Health consensus definition as a demonstrated proxy for long-term respiratory and neurodevelopmental outcomes in extremely low birth weight infants.Methods-We analyzed clinical data from twin pairs born at ≤30 completed weeks gestation in British Columbia, Canada, between 1993 and 2006. Differences in correlations between monozygotic (MZ) and dizygotic (DZ) twin pairs and model-fitting approaches were used to quantify the relative contribution of genetic, shared environmental and non-shared environmental effects.Results-Among 318 twins of known zygosity, monozygotic twin pair similarities were greater than those observed for dizygotic pairs, which suggest significant heritability for bronchopulmonary dysplasia. Model-fitting analyses confirmed that genetic effects accounted for 82% and 79% of the observed variance in bronchopulmonary dysplasia susceptibility, defined on the basis of the need for supplemental oxygen at 36 weeks or the National Institutes of Health consensus definition, respectively. Variations in rates of hemodynamically significant PDA were largely accounted for by genetic effects, whereas variance in susceptibility to blood-borne bacterial infections was largely attributable environmental factors both common and unique to each infant.Conclusions-Susceptibility to BPD and persistence of PDA are both significantly heritable. Our study strengthens the case for investigating further genetic risk stratification markers useful for predicting the most significant long-term respiratory and neurodevelopmental consequences of bronchopulmonary dysplasia in premature neonates.

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“…Several definitions of CLD in the newborn are commonly used. [38][39][40] Both oxygen dependency at 28 days with a compatible chest X-ray and oxygen dependency at 36 weeks PCA predict long-term adverse outcomes. 40 As a result of this, cytokine genotypes were correlated to both of these outcomes.…”

Section: Ta Cytokine Determinationmentioning

confidence: 99%

The TNF−α –308, MCP−1 –2518 and TGF−β1 +915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants

et al. 2003

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Chronic lung disease (CLD) in premature newborns is associated with increased concentrations of inflammatory cytokines in tracheal aspirates (TA). We determined if polymorphisms of cytokine genes influence the risk of developing CLD by genotyping 178 mechanically ventilated very low birth weight (VLBW) infants for the tumor necrosis factor-a (TNF-a) À308 G/A, transforming growth factor-b 1 (TGF-b 1 ) +915 G/C and monocyte chemoattractant protein-1 (MCP-1) À2518 A/G polymorphisms. Genomic DNA was isolated from TA and genotypes determined by restriction length polymorphism. There was no effect of any of these polymorphisms on the development of CLD (29 vs 23%, P ¼ 0.371, TNF-a À308 AA/AG vs TNF-a À308 GG; 23 vs 26%, P ¼ 0.681, MCP-1 À2518 GG/AG vs MCP-1 À215-8 AA; 24 vs 24%, P ¼ 0.978, TGF-b 1 +915 CG vs TGF-b 1 +915 GG). TA IL-8 and MCP-1 concentrations were not different between genotype groups. Infants with the TNF-a À308 A allele had increased risk of IVH (RR 2.07; 95% CI 1.02-4.18, P ¼ 0.041) and infants with the TGF-b 1 +915 C allele were at greater risk of death (32 vs 9%, P ¼ 0.016). These data suggest that these polymorphisms do not play a significant role in determining risk for CLD in preterm infants, but may play a role in other complications in the neonatal period.

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Bronchopulmonary dysplasia: Clinical presentation

Cited by 454 publications

References 11 publications

A New Score for Predicting Neonatal Very Low Birth Weight Mortality Risk in the NEOCOSUR South American Network

A New Score for Predicting Neonatal Very Low Birth Weight Mortality Risk in the NEOCOSUR South American Network

Heritability of Bronchopulmonary Dysplasia, Defined According to the Consensus Statement of the National Institutes of Health

The TNF−α –308, MCP−1 –2518 and TGF−β1 +915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants

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