Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors

Ito, Masato; Kato, Shin; Saito, Makoto; Miyahara, Naoyuki; Arai, Hirokazu; Namba, Fumihiko; Ota, Erika; Nakanishi, Hidehiko

doi:10.3390/biomedicines11020553

Cited by 7 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to a retrospective study by Smith et al (14), the incidence of BPD is signi cantly greater in twins (29.9%) than in singletons (23.6%). Another study reported similar results (15). These ndings highlight that twins face unique challenges related to foetal growth, the intrauterine environment, and delivery, which may increase the risk of BPD.…”

Section: Introductionsupporting

confidence: 58%

Differences in Risk Factors and Predictors of Preterm Twin Infants with Bronchopulmonary Dysplasia: A retrospective study

LI,

DUMBUYA,

CHEN

et al. 2024

Preprint

View full text Add to dashboard Cite

Background To evaluate the differences in clinical characteristics, BPD risk factors and predictors in preterm twin infants. Methods A retrospective, single-centre study was conducted on preterm twins admitted to the neonatal intensive care unit (NICU) of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, from January 2021 to December 2022. Data, including perinatal and critical postpartum data, were collected for twin pairs with gestational age (GA) ≤ 31 weeks and birth weight ≤ 2500 g from clinical medical records, including perinatal data and critical postpartum information. Chi-square or nonparametric tests and multiple logistic regression models were used to analyse significant clinical parameters and characteristics for BPD between the two groups and to compare risk factors, respectively. Results A total of 233 twin infants were included in this study. Among them, 183 pairs had BPD, consisting of 366 twin infants. Among twins with BPD, 184 (50.3%) were discordant, and 182 (49.7%) were in one of the twin pairs with BPD. Extremely low birth weight infants (< 1000 g) and extremely preterm infants (GA < 28 weeks) were typical of twin pairs with both BPD (35.9% and 52.7%), while low birth weight infants (< 2500 g) and very preterm infants (GA > 28 < 31 weeks) were more common in one of the twin pairs with BPD (35 .2% and 86.8%). Preterm infants with a length/height between 25 cm and 35 cm were typically twin pairs with BPD (79.7% vs 20.3%). Among the twin pairs with both BPDs, 94 (51.1%) had a head circumference of 22–26 cm compared with 34 (18.7%). Among the risk factors, asphyxia, PDA, RDS, pulmonary hypertension, ROP, IVH, bloodstream infections, hypothyroidism, and hypoproteinaemia were more prevalent in both pairs of twins with BPD. Among the interventions, HFV, IMV, BiPAP, oxygen therapy, and HFNC therapy had significantly different effects on the two groups. The duration of these interventions also significantly differed between the two groups. Conclusions These data demonstrated that risk factors and predictors of BPD in preterm twins vary in magnitude and severity, particularly in extremely low birth weight infants, extremely preterm infants with smaller head circumferences, and infants with short length/height. The need for mechanical ventilation, duration of ventilation, and medication use increased in pairs of twins with both BPD. Thus, this study adds to the existing knowledge on the early detection of risk factors and stratification of clinical management strategies for preterm twins at the individual level.

show abstract

Section: Introductionsupporting

confidence: 58%

Differences in Risk Factors and Predictors of Preterm Twin Infants with Bronchopulmonary Dysplasia: A retrospective study

LI,

DUMBUYA,

CHEN

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…One surprising finding was the statistical significance of a low APGAR score (<7) at 5 min in the BPD group but not in moderate-to-severe BPD/death groups. The impact of a low Apgar score on the development of BPD has yielded inconsistent results across studies [29,30], with the role of a low Apgar score as a risk factor for moderate-to-severe BPD/death remaining inconclusive. However, ETT or CPCR in initial resuscitation was statistical significant in moderate-to-severe BPD/death groups but not in the BPD group.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study

Huang,

Lin,

Lin

et al. 2023

Children

View full text Add to dashboard Cite

Bronchopulmonary dysplasia (BPD) is a major respiratory condition mainly affecting premature infants. Although its occurrence is global, risk factors may differ regionally. This study, involving 3111 infants with birth weight ≤ 1500 gm or gestational age (GA) < 30 weeks, aimed to identify risk factors for BPD and BPD/mortality in Taiwan using data from the Taiwan Neonatal Network. The BPD criteria were based on the National Institute of Child Health and Human Development standards. Average GA was 27.5 weeks, with 23.7% classified as small for GA (SGA). Multivariate analysis highlighted low GA, low birth weight, and other perinatal factors as significant risk indicators for BPD. For moderate-to-severe BPD, additional risk factors included male gender and SGA, endotracheal intubation (ETT) or cardiopulmonary cerebral resuscitation (CPCR) in initial resuscitation. In the moderate-to-severe BPD/death group, SGA and ETT or CPCR in initial resuscitation remained the only additional risk factors. The study pinpoints male gender, SGA and ETT or CPCR as key risk factors for moderate-to-severe BPD/death in low-birth-weight infants in Taiwan, offering a basis for focused interventions and further research.

show abstract

Respiratory care for chronic lung disease

Nakanishi,

Namba,

Nakamura

2025

Neonatal Intensive Care for Extremely Preterm Infants

View full text Add to dashboard Cite

Bronchopulmonary Dysplasia in Extremely Premature Infants: A Scoping Review for Identifying Risk Factors

Cited by 7 publications

References 74 publications

Differences in Risk Factors and Predictors of Preterm Twin Infants with Bronchopulmonary Dysplasia: A retrospective study

Differences in Risk Factors and Predictors of Preterm Twin Infants with Bronchopulmonary Dysplasia: A retrospective study

Comprehensive Analysis of Risk Factors for Bronchopulmonary Dysplasia in Preterm Infants in Taiwan: A Four-Year Study

Respiratory care for chronic lung disease

Contact Info

Product

Resources

About