Bronchopulmonary Dysplasia in Preterm Neonates in a Level III Neonatal Unit in India

Bhunwal, Savita; Mukhopadhyay, Kanya; Bhattacharya, Saurav; Dey, Pranab; Dhaliwal, Lakhbir Kaur

doi:10.1007/s13312-018-1319-z

Cited by 20 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…to 50%, likely because of differences in gestational age or birth weight criteria for confirmed a BPD diagnosis [5][6][7][8][9][10]. A multicenter retrospective analysis from China showed that the incidence of BPD decreases with increase in gestational age and weight [11], which is consistent with the results of previous studies.…”

Section: Discussionsupporting

confidence: 80%

Risk factors of bronchopulmonary dysplasia in premature infants under 32 weeks of gestation: A retrospective case-control study

Cui

2020

Preprint

View full text Add to dashboard Cite

Background: Bronchopulmonary dysplasia (BPD) in preterm infants is one of the most serious complications in neonatology, as it significantly affects the quality of life of preterm children. We retrospectively analyze the incidence and risk factors of BPD in premature infants under 32 weeks of gestation age.Methods: Clinical data of premature infants with gestational age ≤32 weeks admitted to the neonatal intensive care unit of the First Affiliated Hospital of Nanjing Medical University from 2015 to 2017 were selected for this retrospective case-control study. The patients were classified into the BPD and control groups based on the clinical diagnosis. We compared the general condition, treatments, complications, and clinical outcome of premature infants in both groups. Student’s t-test, non-parametric test, and binary logistic regression were used to analyze the occurrence of BPD and its potential risk factors.Results: A total of 213 premature infants aged ≤32 gestational weeks were included in the study; of these, 81 (38%) were diagnosed with BPD. The gestational age (29.14±1.88 weeks vs. 30.82±0.98 weeks, P<0.001) and weight (1240±314.87 g vs. 1584.77±318.18 g, P<0.001) in the BPD group were lower than those in the control group. The liquid quantity, urine volume, and calorie intake of preterm infants in the BPD group within one week after birth were significantly lower than those of infants in the control group. Logistic regression analysis showed that invasive mechanical ventilation (OR=5.065, 95% CI: 1.680–15.266); use of erythrocyte suspension (OR=10.146, 95% CI: 1.860–55.336); and PCO2 in early postnatal arterial blood gas (OR=1.122, 95% CI: 1.024–1.229) were risk factors for BPD. On the other hand, gestational age (OR=0.657, 95% CI: 0.460–0.937); calorie intake (OR=0.917, 95% CI: 0.874–0.963); PO2 (OR=0.925, 95% CI: 0.870–0.985); and pH in early postnatal arterial blood gas (OR<0.001, 95% CI: 0.000–0.156) were protective factors for BPD.Conclusion: The incidence of BPD in very low and extremely low birth weight infants is high. Maintaining early internal environment stability, increasing early calorie intake, shortening invasive mechanical ventilation time, reducing blood transfusion, and closing patent ductus arteriosus could likely reduce the incidence of BPD.

show abstract

Section: Discussionsupporting

confidence: 80%

Risk factors of bronchopulmonary dysplasia in premature infants under 32 weeks of gestation: A retrospective case-control study

Cui

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…EPICure 2 study [4] showed nearly 60% of babies ≤26 weeks had BPD. Studies from India [20,21] reported an incidence of BPD of 28.7%, 10.7% & 11.2% in infants less than 28 weeks, 29-30 weeks and 31-32 weeks respectively The BPD rates from Indian centre in this study is lower than reported studies from India. Necrotising enterocolitis ≥stage 2 is 11.5% and 12.6% in U.K and Indian cohort, results are comparable to the previous studies [23].Number of babies with severe Retinopathy of Prematurity (ROP) and number of ROP needing treatment with laser or Avastin was signi cantly higher in Indian centre (12.9% vs 7.7%) despite higher gestational age of cohort than the UK centre possibly explained by difference in practices or higher risk factors.…”

Section: Discussioncontrasting

confidence: 71%

Comparitive Study Of Short-Term Outcomes Of Preterm Babies ≤30 Weeks In A Tertiary Care Hospital Between India And The U.K

Diggikar¹,

Nagesh²,

Kumar³

et al. 2020

Preprint

View full text Add to dashboard Cite

Large numbers of preterm babies are born in middle income countries and neonatal care is improving in these countries. However, comparative clinical outcomes of preterm babies between a tertiary neonatal unit from middle income country and higher income country is limited. Objective: To compare the clinical profile and short-term outcomes of preterm babies ≤ 30 weeks gestation admitted to a tertiary care hospital in India and the U.K. Design: Retrospective cohort observational study using anonymised data from Electronic Patient Records. Setting: Regional tertiary neonatal intensive care unit (NICU) of Manipal Hospitals, Bangalore, India and Homerton University Hospital, London, UK. Participants: Preterm babies born at ≤ 30 weeks gestation admitted to NICUs over five year period (January 2011 to December 2015). Infants with major congenital abnormalities were excluded. Intervention: This is an observational study and routine care was provided as per departmental standard protocols. Main outcome measures: Comparison of neonatal unit mortality between two centres, infant morbidities till discharge from neonatal unit. Results: A total of 740 babies from the U.K centre and 294 babies from Indian centre were enrolled into the study. The mean gestational age in the U.K cohort was 26.6 ± 2.16 weeks, whereas in Indian cohort was 28.4 ± 1.66 weeks (p,<0.001). A significantly lower number of mothers received antenatal steroid (37% v 73%), and higher number of babies were inborn (78.6%) in Indian centre compared to the UK centre (67.3%; p < 0.001). Incidence of BPD and IVH ≥ grade 2 was significantly lower, and ROP needing treatment was significantly higher in Indian centre. Higher number of babies were treated for ductus arteriosus and incidence of culture positive sepsis was significantly high in Indian cohort babies. Survival of babies born at gestational age > 28 weeks was comparable between the U.K and Indian centres. Survival of babies born at ≤ 28 weeks gestation was lower in Indian centre. Conclusions and relevance: The survival of babies above 28 weeks prematurity was comparable between a tertiary care centre in India and the U.K. However, survival of babies ≤ 28 weeks gestation was lower in Indian centre. Incidence of ROP and sepsis was higher in Indian centre.

show abstract

“…This low incidence may be because of inclusion of moderate preterm infants in the study, exclusion of infants with gestation <25 weeks and increased overall mortality. Bhunwal et al 19 reported almost similar incidence (11.2%) of infants requiring oxygen for ≥28 days among the infants with gestation <33 weeks and requiring respiratory support in the first 3 days of life. De Campos Bannwart et al 8 developed two predicting models for LOS in infants with very low birth weight.…”

Section: Discussionmentioning

confidence: 88%

“…Apart from the weight and gestational age at birth, in our study, many other antenatal factors (doppler abnormalities, severe SGA status at birth) and neonatal morbidities (need for resuscitation, RDS, seizures, sepsis, NEC, major malformations and BPD) independently influenced hospital duration (Tables 5 and 6). Among the perinatal factors, severe SGA status had the highest influence on LOS with an increase of 21 (19)(20)(21)(22)(23) days. As foetal growth restriction is more common in developing countries like India, severe SGA status at birth should be considered as an important factor in influencing the LOS.…”

Section: Discussionmentioning

confidence: 99%

Predictors of length of hospital stay among preterm infants admitted to neonatal intensive care unit: Data from a multicentre collaborative network from India (INNC: Indian National Neonatal Collaborative)

Murki

Vardhelli

Deshabhotla

et al. 2020

J Paediatrics Child Health

View full text Add to dashboard Cite

Aim: Prediction of length of stay (LOS) among preterm neonates is important for counselling of parents and for assessing neonatal intensive care unit (NICU) census and economic burden. The aim of this study is to evaluate perinatal and postnatal factors that influence LOS in preterm infants (25-33 weeks of gestation) admitted to participating NICUs of Indian National Neonatal Collaborative (INNC). Methods: From the INNC database, the data which were prospectively entered using uniformed pre-defined criteria were analysed. Results: A total of 3095 infants were included from 12 centres. Every week decrease in gestation increased LOS by 9 days.

show abstract

Bronchopulmonary Dysplasia in Preterm Neonates in a Level III Neonatal Unit in India

Abstract: Chorioamnionitis, PDA and sepsis were significantly associated with BPD.

Cited by 20 publications

References 12 publications

Risk factors of bronchopulmonary dysplasia in premature infants under 32 weeks of gestation: A retrospective case-control study

Risk factors of bronchopulmonary dysplasia in premature infants under 32 weeks of gestation: A retrospective case-control study

Comparitive Study Of Short-Term Outcomes Of Preterm Babies ≤30 Weeks In A Tertiary Care Hospital Between India And The U.K

Predictors of length of hospital stay among preterm infants admitted to neonatal intensive care unit: Data from a multicentre collaborative network from India (INNC: Indian National Neonatal Collaborative)

Contact Info

Product

Resources

About