Bronchopulmonary Dysplasia

Keller, Roberta L.; Ballard, Roberta A.

doi:10.1016/b978-0-323-40139-5.00048-6

Avery's Diseases of the Newborn 2018

DOI: 10.1016/b978-0-323-40139-5.00048-6

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Bronchopulmonary Dysplasia

Roberta L. Keller¹,

Roberta A. Ballard²

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Cited by 2 publications

References 246 publications

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Developing a machine learning-based tool to extend the usability of the NICHD BPD Outcome Estimator to the Asian population

2022

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The NICHD BPD Outcome Estimator uses clinical and demographic data to stratify respiratory outcomes of extremely preterm infants by risk. However, the Estimator does not have an option in its pull-down menu for infants of Asian descent. We hypothesize that respiratory outcomes in extreme prematurity among various racial/ethnic groups are interconnected and therefore the Estimator can still be used to predict outcomes in infants of Asian descent. Our goal was to apply a machine learning approach to assess whether outcome prediction for infants of Asian descent is possible with information hidden in the prediction results using White, Black, and Hispanic racial/ethnic groups as surrogates. We used the three racial/ethnic options in the Estimator to obtain the probabilities of BPD outcomes for each severity category. We then combined the probability results and developed three respiratory outcome prediction models at various postmenstrual age (PMA) by a random forest algorithm. We showed satisfactory model performance, with receiver operating characteristics area under the curve of 0.934, 0.850, and 0.757 for respiratory outcomes at PMA 36, 37, and 40 weeks, respectively, in the testing data set. This study suggested an interrelationship among racial/ethnic groups for respiratory outcomes among extremely preterm infants and showed the feasibility of extending the use of the Estimator to the Asian population.

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Developing a machine learning-based tool to extend the usability of the NICHD BPD Outcome Estimator to the Asian population

2022

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An Extremely Preterm Infant Born at 23 Weeks' Gestation With an Interrupted Aortic Arch Complex: A Case Report

Haga¹,

Itoh²,

Ishiguro³

et al. 2023

Cureus

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We present a case of an infant male born at 23 weeks' gestation with an interrupted aortic arch (IAA) complex. We treated the patient with hypoxic gas ventilation to address developing systemic undercirculation in the acute postnatal phase. As the symptoms of bronchopulmonary dysplasia evolved, hypoxic gas ventilation was no longer required to stabilize the hemodynamics. The patient was discharged home after undergoing the palliative surgical procedure of bilateral pulmonary artery banding and ductus arteriosus stent implantation. Although he suffered from pulmonary hypertension, it was controllable with oxygen supplementation and pulmonary vasodilators. There are limited therapeutic options available for extremely preterm infants with critical congenital heart defects (CHDs). Hypoxic gas ventilation might be considered as one of the options, with its risks taken into account, to manage extremely preterm infants with CHDs with pulmonary overcirculation before performing surgical interventions.

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Bronchopulmonary Dysplasia

Cited by 2 publications

References 246 publications

Developing a machine learning-based tool to extend the usability of the NICHD BPD Outcome Estimator to the Asian population

Developing a machine learning-based tool to extend the usability of the NICHD BPD Outcome Estimator to the Asian population

An Extremely Preterm Infant Born at 23 Weeks' Gestation With an Interrupted Aortic Arch Complex: A Case Report

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