Bronchopulmonary precapillary blood flow during cardiopulmonary bypass

Deal, Cedric W.; Louis, Eugene L. St.; Kerth, William J.; Osborn, John J.; Gerbode, Frank

doi:10.1016/0002-8703(68)90115-4

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…10 Bronchial arterial blood flow has been measured previously in animals with a variety of techniques. [11][12][13][14][15] However, the results of these studies are inconclusive. Bronchial arterial blood flow was found to be increased 10 or decreased 16 after acute obstruction of the PA. During CPB, an estimate of bronchial blood flow is possible by collecting the blood returning to the vent catheter.…”

Section: Discussionmentioning

confidence: 99%

Cardiopulmonary bypass reduction of bronchial blood flow: A potential mechanism for lung injury in a neonatal pig model

Schlensak

Doenst

Preusser

et al. 2002

The Journal of Thoracic and Cardiovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Cardiopulmonary bypass reduction of bronchial blood flow: A potential mechanism for lung injury in a neonatal pig model

Schlensak

Doenst

Preusser

et al. 2002

The Journal of Thoracic and Cardiovascular Surgery

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“…Flow values of 140 Ϯ 182 (SD) ml/min (3.23-4.15% of the pump flow) were recorded. During the same conditions, Deal et al (14) found the flow to be 3.8 Ϯ 2.7% of the pump flow. Although measurements were made under nonphysiological conditions, they appear more reliable than previous ones using Fick's principle.…”

Section: Discussionmentioning

confidence: 87%

Human bronchial artery blood flow after lung Tx with direct bronchial artery revascularization

Nørgaard¹,

Hove

Efsen

et al. 1999

Journal of Applied Physiology

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The inaccuracy of measuring human bronchial artery blood flow has previously been considerable. En bloc double-lung transplantation with bronchial artery revascularization (BAR) using a single conduit offers the unique opportunity of direct measurement of the total bronchial artery blood flow. In eight en bloc double-lung-transplanted patients with complete BAR, the basal blood flow was measured by using a 0.014-in. Doppler guide wire and arteriography. The average peak velocity in the conduit was 12-73 cm/s [+/-2.1 (SD) cm/s], and the conduit diameter was 1.7-3.1 mm [+/-0.10 (SD) mm], giving individual basal flow values between 19 and 67 ml/min [+/-5 (SD) ml/min], or 0.2-1.9% of estimated cardiac output. In three patients basal measurements were followed by injection of nitroglycerin and verapamil into the conduit. This increased the bronchial artery flow to 121-262% of basal values (31-89 ml/min). The measured values appear more physiologically plausible than previous bronchial artery blood flow measurements in humans.

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“…Indeed the presence of collateral aortic to pulmonary blood flow is essential for survival in patients with Tetralogy of Fallot with pulmonary atresia and pulmonary stenosis (12), and this flow may well be greater than that originating from the right ventricle. Deal has reported in patients with Tetralogy of Fallot that the amount of bronchopulmonary precapillary flow could be as great as 11% of the patients flow during bypass (30). Figures 6 and 7 are angiograms of significant collateralization of a patient with Tetralogy of Fallot with pulmonary atresia which show both direct and non-direct aortic branch communications with the pulmonary system.…”

Section: Discussionmentioning

confidence: 99%

Does Cardioplegic Protection of the Pediatric Patient Heart Vary According to the Cardiac Defect?

Stammers,

Riley

1991

J Extra Corpor Technol

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The technique of myocardial protection utilized during pediatric cardiac surgery may be influenced by the congenital lesion, and be related to the pathophysiological changes associated with myocardial dysfunction and altered systemic and pulmonary circulations. The present study is a retrospective examination of the cardioplegic and cardiopulmonary bypass parameters utilized during pediatric cardiac surgery. 1016 pediatric patients were subdivided according to cardiac lesion, with the following parameters recorded: Age at operation, weight, body surface area, cardioplegia (CP) volume administered, cardioplegia dose schedule, cardiopulmonary bypass and cross clamp times, and low perfusate temperature. Cardioplegia volume administration was indexed according to weight and body surface area and patients were categorized as being either acyanotic or cyanotic The following results (Mean ±SEM) were obtained between groups not significantly different in respect to weight and body surface area: Defect CP/Unit Weight (ml/Kg) P Value ASD vs Pulmonary Stenosis 26.7+0.8 vs 38.0±2.6 .001 ASD vs Pulmonary Atresia 26.7+0.8 vs 34.1+3.4 .001 A/VSD vs Truncus Arteriosus 30.5+2.1 vs 48.1+4.5 .009 VSD vs Tetralogy of Fallot 36.3+4.2 vs 35.2+1.1 .79 LV Outflow vs RV Outflow Lesions 32.3+2.8 vs 35.5+0.9 .27 Patients with pulmonary obstructive lesions had significantly more cardioplegic volume administered than certain acyanotic lesions. This may reflect a greater susceptibility to ischemic and reperfusion related phenomena in cyanotic compared to acyanotic patients. Cardioplegic protection of the pediatric heart may be influenced by multiple factors related to the cardiac lesion, necessitating preferential preservation strategies.

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Bronchopulmonary precapillary blood flow during cardiopulmonary bypass

Cited by 9 publications

References 8 publications

Cardiopulmonary bypass reduction of bronchial blood flow: A potential mechanism for lung injury in a neonatal pig model

Cardiopulmonary bypass reduction of bronchial blood flow: A potential mechanism for lung injury in a neonatal pig model

Human bronchial artery blood flow after lung Tx with direct bronchial artery revascularization

Does Cardioplegic Protection of the Pediatric Patient Heart Vary According to the Cardiac Defect?

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