2001
DOI: 10.1002/ppul.1048
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Bronchoscopic instillation of surfactant in acute respiratory distress syndrome

Abstract: Abnormalities of surfactant action in acute respiratory distress syndrome (ARDS) result in decreased lung compliance and significant hypoxemia. Several case reports and small studies suggest that there is an improvement in patients with ARDS following the administration of surfactant. However, there is no clear-cut ideal method for surfactant administration. The bronchoscopic administration of surfactant may represent an effective method of surfactant delivery in ARDS. Bronchoscopic instillation offers the the… Show more

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Cited by 15 publications
(18 citation statements)
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“…Bronchoscopic administration of surfactant may represent an effective method of delivery in acute respiratory distress syndrome [31]. Furthermore, in persistent atelectasis unresponsive to medical therapy bronchoscopic instillation of recombinant human DNase has been found to be useful [17].…”
Section: Drug Applicationmentioning
confidence: 99%
“…Bronchoscopic administration of surfactant may represent an effective method of delivery in acute respiratory distress syndrome [31]. Furthermore, in persistent atelectasis unresponsive to medical therapy bronchoscopic instillation of recombinant human DNase has been found to be useful [17].…”
Section: Drug Applicationmentioning
confidence: 99%
“…In clinical studies, surfactant is normally instilled as a bolus [7], sometimes bronchoscopically on a segmental or lobar level [15]. The bolus method appears to be more efficacious than slow tracheal instillation or aerosol delivery [16,17], but there are disadvantages.…”
Section: Discussionmentioning
confidence: 99%
“…The aim of bronchoscopic surfactant administration is to achieve an even distribution within the bronchial tree and to avoid preferential surfactant deposition in lung areas without atelectasis, which would further increase the ventilation imbalance. To our knowledge, bronchoscopic surfactant administration for ARDS using a segment-to-segment approach has only been described in a single pediatric case report [26], but it has been studied in adult patients with ARDS [27, 28]. The treatment of atelectasis in pediatric patients, as described in this study, is a new experience.…”
Section: Discussionmentioning
confidence: 99%