1981
DOI: 10.1016/0014-2999(81)90239-9
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Bronchospasm and pressor effects induced in the guinea-pig by leukotriene C4 are probably due to release of cyclooxygenase products

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1983
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Cited by 55 publications
(16 citation statements)
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“…In fact, with this tissue there was an increase in the time required to reach maximal contraction. Since leukotrienes are known to induce some thromboxane A2 (TXA2) release in lung tissue (Piper & Samhoun, 1981;Schiantarelli et al, 1981;Zijlstra et al, 1984), it is possible that TXA2 contributes to the early phase (-10 min) of the OAinduced contraction of parenchyma and that this contribution, although small, is eliminated by indomethacin. Although cyclo-oxygenase inhibitors enhance leukotriene release from chopped lung challenged with antigen or A23187 (Piper & Seale, 1979), enhancement of contraction is never seen when lung is examined as a parenchymal strip preparation (Burka, 1983).…”
Section: Discussionmentioning
confidence: 99%
“…In fact, with this tissue there was an increase in the time required to reach maximal contraction. Since leukotrienes are known to induce some thromboxane A2 (TXA2) release in lung tissue (Piper & Samhoun, 1981;Schiantarelli et al, 1981;Zijlstra et al, 1984), it is possible that TXA2 contributes to the early phase (-10 min) of the OAinduced contraction of parenchyma and that this contribution, although small, is eliminated by indomethacin. Although cyclo-oxygenase inhibitors enhance leukotriene release from chopped lung challenged with antigen or A23187 (Piper & Seale, 1979), enhancement of contraction is never seen when lung is examined as a parenchymal strip preparation (Burka, 1983).…”
Section: Discussionmentioning
confidence: 99%
“…Although this BC is not inhibited by a cyclotravenously into the anaesthetized guinea-pig inoxygenase inhibitor, such as aspirin, or by the simul-taneous addition of the 5-hydroxytryptamine (5-HT) antagonist methysergide with mepyramine, a histamine antagonist, the combination of aspirin, methysergide and mepyramine will abolish BC induced by Paf-acether (Vargaftig et al, 1980;, suggesting an indirect involvement of thromboxane A2 (TXA2). This led us to study whether Paf-acether releases TXA2 from guinea-pig lungs, and since it did so, to compare its effectiveness with that of bradykinin (Bk) and leukotriene (LT) C4, two recognised mediators of BC and TXA2 release, (Collier & Shorley, 1960;Piper & Vane, 1969;Schiantarelli et al, 1981;Sirois et al, 1982), Bk being known to act through the activation of lung phospholipase A2 (Vargaftig & DaoHai, 1972;Damas & Bourdon, 1975;Blackwell et al, 1978).…”
Section: Introductionmentioning
confidence: 99%
“…19 - 21 The hypotensive shock observed in the SHR appears to be a unique phenomenon, since the cysteinyl leukotrienes are only constrictor agents when tested on vas-VOL. 7, No 4, JULY- AUGUST 1985 cular smooth muscles in vitro, 4 7 and the moderate degree of pressor responses seen in vivo in other species 8 -"• "• M - 2I would not be expected to produce prolonged hypotension and shock.…”
mentioning
confidence: 99%