Bronchospasm during excretory urography: lack of specificity for the methylglucamine cation

Mr, Littner; Ulreich, Sidney; Ce, Putman; At, Rosenfield; Meadows, G.A.

doi:10.2214/ajr.137.3.477

Cited by 23 publications

(6 citation statements)

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Contrasting

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“…94,97,99,167 These reactions are compounded by the fact that contrast agents may also produce direct effects on various cellular and/or humoral systems. 76,120,127,130,135,144,203 An immediate dis continuation of contrast agent infusion is absolutely necessary during these reactions. Various measures, such as restoration of cardiac action, monitoring of blood pressure, and administration of steroids and other adjunct drugs, are useful.…”

Section: Fig 23 Reactions To Contrast Media and Their Manage Mentmentioning

confidence: 99%

Molecular Markers of Contrast Media-Induced Adverse Reactions

Fareed¹,

Moncada²,

Messmore³

et al. 1984

Semin Thromb Hemost

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Currently used routine laboratory screening methods are not reliable in the prediction of contrast media-related adverse reactions. Cost-effective laboratory methods for various molecular markers of pathophysiologic activation have now become available. In vitro activation tests in high-risk patients may prove to be useful in the prediction of contrast-induced activation of various adverse reactions. If prior clinical evaluation of a patient suggests an ongoing pathologic process, profiling of the following molecular markers may prove to be useful and helpful in avoiding contrast-induced adverse reactions: Fibrinopeptide A, platelet factor 4, thromboxane B2, 5-HETE, physiologic inhibitors of proteases, B beta 15-42 related peptides, bradykinin/kininogen, and anaphylactozins. In patients suspected of reacting to contrast agents, a small dose of 1 to 5 ml can be injected as a bolus and molecular marker profiling on blood drawn after the infusion may prove to be useful screening tests. Additional clinical studies are needed to prove this. However, this screening test should be performed with extreme caution, since some of the patients are known to react to as little as 1 ml dose. The safety of newly developed nonionic contrast agents can be readily assessed by profiling various molecular markers of adverse reactions, which provide a more reliable and quantitative assessment of contrast-induced adverse reactions. Based on molecular marker profiling, various prophylactic agents can be given to high-risk patients to avoid contrast-induced adverse reactions.

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Section: Fig 23 Reactions To Contrast Media and Their Manage Mentmentioning

confidence: 99%

Molecular Markers of Contrast Media-Induced Adverse Reactions

Fareed¹,

Moncada²,

Messmore³

et al. 1984

Semin Thromb Hemost

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show abstract

“…Lung is a key target for water soluble ICM, and this is reflected by bronchospasm, that constitutes the most common adverse event, among respiratory reactions, to ICM (8), with a reported occurrence of 23% and 5% cases of moderate and severe reactions, respectively (9). Although symptomatic / severe bronchospasm seems to be rare, sub-clinical bronchospasm assessed by a fall in FEV1 values is quite common, particularly in patients with an history of allergy and /or asthma (10). Furthermore, a bronchospasm can develop both during systemic reactions (e.g., IgE / non IgE-mediated anaphylaxis) and as isolated events (10).…”

Section: A) Bronchospasm As a Respiratory Adverse Event To Icmmentioning

confidence: 99%

Bronchospasm and iodinated contrast media (ICM): an accurate evaluation is mandatory

Liccardi¹,

Martini²,

Bilò³

et al. 2024

Eur Ann Allergy Clin Immunol

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“…While symptomatic bronchospasm is rare, occurring in 0.01 % of patients (Morcos 2003), subclinical bronchospasm, detected by a fall in forced expiratory volume in 1 s (FEV1), is common. It tends to be less pronounced with lowosmolar non-ionic contrast media (Littner et al 1977(Littner et al , 1981Dawson et al 1983a;Longstaff and Henson 1985). However, Wilson and Davis (1988) found that both high-osmolar ionic and low-osmolar non-ionic contrast media produce a comparable fall in FEV and forced vital capacity.…”

Section: Effects Of Contrast Media On Airways Resistancementioning

confidence: 99%

“…The adverse respiratory reactions that have been reported with the intravascular use of contrast media include apnea, dyspnea, and bronchospasm (Littner et al 1977(Littner et al , 1981Dawson et al 1983a;Longstaff and Henson 1985;Wilson and Davis 1988;Morcos 2000Morcos , 2003. Bronchospasm has been reported to be a contributory factor in 23 % of moderate and 5 % of severe adverse reactions to intravascular administration of radiographic contrast media (Morcos 2003).…”

Section: Effects Of Contrast Media On Airways Resistancementioning

confidence: 99%

Pulmonary Effects of Iodine-Based Contrast Media

Morcos

2014

Medical Radiology

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Bronchospasm during excretory urography: lack of specificity for the methylglucamine cation

Cited by 23 publications

References 0 publications

Molecular Markers of Contrast Media-Induced Adverse Reactions

Molecular Markers of Contrast Media-Induced Adverse Reactions

Bronchospasm and iodinated contrast media (ICM): an accurate evaluation is mandatory

Pulmonary Effects of Iodine-Based Contrast Media

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