Bronhoadenitis simplex in mycoplasma pneumonia in the child (differential diagnostics and treatment)

Abstract

Background. Mycoplasma pneumoniae is included in the group of atypical pathogens of acute respiratory diseases. Mycoplasma pneumoniae is characterized by a tendency to prolonged course with progressive changes in the lungs. Main value in the confirmation of mycoplasma infection has microbiome in biosubstrates selection and serological diagnostics: the determination of specific immunoglobulins IgM or IgG in the dynamics to M. pneumoniae. Antibacterial therapy of mycoplasma pneumonia is prescribed based on the sensitivity of the pathogen to them. The duration of antibiotic treatment of mycoplasma pneumonia is determined by the dynamics of clinical and radiological data. Materials and methods. The article describes the features of the clinical course of mycoplasma pneumonia in a patient with tubinfection proceeding with bronchoadenitis and obstruction of the bronchus, which necessitated a differential diagnosis with tuberculosis of the intrathoracic lymph nodes and the appointment of repeated courses of antibiotic treatment.Results. In the described clinical case, the duration of Mycoplasma infection exceeded 3.5 months, during which time the patient received several courses of antibiotics. Mycoplasma pneumonia had a prolonged course, accompanied by bronchoadenitis.Conclusion. Our observations show the need to study the effectiveness of extended courses of antibiotics from the azalid group in the treatment of prolonged and complicated forms of Mycoplasma pneumonia.

Gene therapy for Cystic Fibrosis: recent advances and future prospects

“…Impairment of the transmembrane transport of chlorine ions changes transmembrane conductance for water molecules and, as a result, causes dehydration and increased viscosity of the secretion. This is what determines the organs primarily affected by CF: a thick viscous secretion is formed on the epithelial surface and blocks bronchopulmonary airways and glandular lumens, which interferes with the normal functioning of the respective organs [ 2 ].…”

“…Here, the delivery method should be selected taking into account the significantly reduced efficacy of aerosol administration due to the thick secretion in the bronchioles. The latter also imposes additional restrictions on the gene therapy, since the vector should not only ensure the effective expression of the functional CFTR protein but should also penetrate submucosal glandular cells and the superficial mucosal epithelium covered by the thick secretion [ 2 ].…”

“…This ion channel ensures normal functioning of epithelial cells in the lungs, intestines, pancreas, and some other organs. CFTR regulates sodium and chlorine ion transport across the membrane, as well as water exchange in secretory the epithelial cells in the respiratory, gastrointestinal, hepatobiliary, and reproductive systems [ 2 , 3 ]. Impairment of the protein’s function causes a severe progressive pathology that clinically manifests itself in pulmonary (respiratory failure), pancreatic, and hepatic lesions (sometimes as severe as cirrhosis), as well as increased electrolyte content in the perspiratory secretion.…”

“…The main complications associated with CF include pulmonary and gastric hemorrhages, intestinal ob- struction, bronchial hyperresponsiveness, edemas, abscesses, pneumo- and pyopneumothorax, pulmonary heart disease, maxillary sinusitis, liver cirrhosis, rectal prolapse, developmental impairments, sterility, diabetes mellitus, etc. [ 2 ].…”

A clinical case of plastic bronchitis on the background of community-accombined pneumonia

“…Широко распространены аппаратные методики для эффективного удаления сгустков -«помощники кашля» (CoughAssist devise) и аппарат высокочастотной компрессии грудной клетки (Vest). Также эффективны дыхательные упражнения, лечебная физкультура (ЛФК) и клопф-массаж [27].…”