Bronquiolite aguda por rinovírus em lactentes jovens

Pitrez, Paulo Márcio; Stein, Renato T.; Stuermer, Larissa; Macedo, Izolete Santos; Schmitt, Virgínia M.; Jones, Marcus Herbert; Arruda, Eurico

doi:10.1590/s0021-75572005000600014

Cited by 7 publications

(9 citation statements)

References 19 publications

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“…After the screening by full text process, 136 studies were included for data extraction. During the data extraction process, 62 studies were excluded, leaving 74 for analyses (Figure ). Most studies were performed in pediatric populations from Brazil, Argentina, Chile, Mexico, and Uruguay.…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta‐analysis of respiratory syncytial virus infection epidemiology in Latin America

Bardach

Rey‐Ares

Cafferata

et al. 2013

Reviews in Medical Virology

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Respiratory syncytial virus (RSV) is a frequent cause of acute respiratory infection and the most common cause of bronchiolitis in infants. The aim of this systematic review and meta-analysis was to obtain a comprehensive epidemiological picture of the data available on disease burden, surveillance, and use of resources in Latin America. Pooled estimates are useful for cross-country comparisons. Data from published studies reporting patients with probable or confirmed RSV infection in medical databases and gray literature were included from 74 studies selected from the 291 initially identified. When considering all countries, the largest pooled percentage RSV in low respiratory tract infection patients was found in the group between 0 and 11 months old, 41.5% (95% CI 32.0–51.4). In all countries, percentages were increasingly lower as older children were included in the analyses. The pooled percentage of RSV in LRTIs in the elderly people was 12.6 (95% CI 4.2–24.6). The percentage of RSV infection in hospitalized newborns was 40.9% (95% CI 28.28–54.34). The pooled case fatality ratio for RSV infection was 1.74% (95% CI 1.2–2.4) in the first 2 years of life. The average length of stay excluding intensive care unit admissions among children with risk factors for severe disease was 12.8 (95% CI 8.9–16.7) days, whereas it averaged 7.3 (95% CI 6.1/8.5) days in otherwise healthy children.We could conclude that infants in their first year of age were the most vulnerable population. To our knowledge, this is the first systematic review on RSV disease burden and use of health resources in Latin America.

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Section: Resultsmentioning

confidence: 99%

Systematic review and meta‐analysis of respiratory syncytial virus infection epidemiology in Latin America

Bardach

Rey‐Ares

Cafferata

et al. 2013

Reviews in Medical Virology

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“…In the South Brazilian region, the RV was detected in 17% of samples from infants younger than six months old hospitalized due to acute bronchiolitis. 16 …”

Section: Discussionmentioning

confidence: 99%

Rhinoviruses as critical agents in severe bronchiolitis in infants

Bastos

Simas

Caserta

et al. 2022

Jornal de Pediatria

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“…RVs were shown to have the capacity to infect the lower respiratory tract and to replicate effectively in lower airway cells even at core temperatures of 37uC, although greater viral yields are obtained at lower temperatures [80][81][82][83]. In line with these findings, studies using sensitive molecular viral detection methods have shown that RVs are a common cause of LRTI in infants and young children; including wheezing disorders, bronchiolitis, and pneumonia with potential subsequent hospitalisations [65][66][67][84][85][86][87][88][89][90][91][92]. Both prevalence and severity of LRTI induced by RVs are further increased in high-risk groups, especially in infants and young children with underlying chronic lung disease, such as those with bronchopulmonary dysplasia [93,94], asthma [66,90,95,96] and cystic fibrosis [97][98][99][100][101].…”

Section: Clinical Features Of Rv Infectionsmentioning

confidence: 99%

Rhinovirus infections in infancy and early childhood

et al. 2012

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Rhinovirus (RV) infections occur early and recurrently in life, imposing a significant burden of disease on infants and young children. They are the most frequent causative agents of both upper and lower respiratory tract infections in this age group and are associated with a broad variety of clinical outcomes, ranging from asymptomatic infections to severe respiratory disease requiring hospitalisation. In addition to their impact on short-term morbidity, RVs are also debated as important pathogens in the development of recurrent wheeze and/or asthma. Several studies in infants at high-risk for atopy and asthma and in hospitalised children have demonstrated that recurrent wheezing illnesses induced by RVs early in life are a risk factor for the development of asthma later in childhood. However, underlying mechanisms are poorly understood. The question whether RVs are directly involved in the development of childhood wheeze and asthma, or whether symptomatic RV infections only represent a proxy for infants prone to develop obstructive lung diseases, is still open. In this review we provide an overview on the role of RVs as important disease-causing agents from infancy to early childhood and discuss their contribution to the subsequent development of childhood wheeze and/or asthma.

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Bronquiolite aguda por rinovírus em lactentes jovens

Cited by 7 publications

References 19 publications

Systematic review and meta‐analysis of respiratory syncytial virus infection epidemiology in Latin America

Systematic review and meta‐analysis of respiratory syncytial virus infection epidemiology in Latin America

Rhinoviruses as critical agents in severe bronchiolitis in infants

Rhinovirus infections in infancy and early childhood

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