Brønsted Acid‐Catalyzed General Petasis Allylation and Isoprenylation of Unactivated Ketones

Abstract

Brønsted acid‐catalyzed general Petasis allylation and isoprenylation of unactivated ketones were developed by using o‐hydroxyaniline and the corresponding pinacolyl boronic esters. This robust methodology provided access to a broad variety of quaternary homoallylic amines and dienyl amines in high yields, proved to be applicable to a gram‐scale synthesis, and allowed the synthesis of a potentially bioactive quaternary homoallylic aminodiol.