Brooke–Spiegler Syndrome: Treatment of Cylindromas with CO2 Laser

Abstract

Brooke–Spiegler syndrome is an autosomal dominant inherited disease characterized by the development of multiple trichoepitheliomas and cylindromas. We report two patients with Brooke–Spiegler syndrome whose scalp cylindromas were treated with a high‐energy continous wave CO2 laser after debulking with bipolar scissors in one of the patients. The special feature in our report is the coexistence of three adnexal skin neoplasms in one case, and the close association of cylindroma and eccrine spiradenoma in the same lesion. We also support that debulking with bipolar scissors prior to laser therapy can be a technique of great benefit in large tumors.

Dermoscopy of Cylindroma

“…In addition, successful treatment with lasers such as the argon, CO 2 , and erbium:Yag plus CO 2 have been reported in adnexal tumors of Brooke-Spiegler syndrome [7–9]. Medical treatments for cylindromas that are currently being tested include sodium salicylate and prostaglandin A1, which are thought to restore growth control by inhibiting NF-B activity [2, 10].…”

SkIndia Quiz 14: Solitary painful skin-colored nodule over the chest

“…Debulking with bipolar scissors prior to laser therapy is beneficial in surgical removal of large tumors. [4]…”

Brooke–Spiegler syndrome – report of four families: treatment with CO2 laser

“…Treatments for the above‐mentioned tumors reported in the literature include surgical removal, electrocoagulation, abrasion, cryotherapy, trichloroacetic acid, retinoic acid, and CO 2 laser 6,22 …”