Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation

Lee, Jae Min; Choi, Sun Sil; Park, Mi Hyeon; Jang, Hyunduk; Lee, Yo Han; Khim, Keon Woo; Oh, Sei Ryang; Park, Jiyoung; Ryu, Hyung Won; Choi, Jang Hyun

doi:10.3390/nu12030773

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…Obesity stimulates increase of IR, leading to the fully developed non‐insulin dependent diabetes mellitus 55 . It does so by chronic low‐grade inflammation of adipose tissue, thus the anti‐inflammatory treatment is able to slow its progress 56 . Genetic background of this pathological process is not yet clear, and examining this field might enable prevention of the development of T2DM in children suffering from obesity.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs as the promising markers of comorbidities in childhood obesity—A systematic review

et al. 2021

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Introduction: Rising child obesity rate creates a need for tools quantifying changes in children suffering from obesity, for purposes of detection or prevention of comorbidities. A candidate for such a role seems to be microRNAs, which in vivo serve as the suppressing factors in gene expression.Objectives: This study aimed at reviewing recent discoveries in this field and concluding directions of research or application of studied molecules.Methods: Repeated browsing of databases and screening of results, led to final approval of 16 articles. Filtered studies examined differences in microRNA expression between subjects with obesity and children suffering from its comorbidities. Results: Studies concerning endothelial dysfunction identified molecules miR-320a and miR-630 as a possible diagnosis and treatment option. Search for the alternative markers in diagnosis of non-alcoholic fatty liver disease suggested value of molecules: miR-199a-5p and miR-122. miR-486, miR-146b, and miR-15b may serve in grading the development of type 2 diabetes in children, although further research raised doubts. Panel of molecules was indicated as useful in early detection of metabolic syndrome and insulin resistance associated alterations. No valid link between studied microRNAs and atherosclerosis was found.Conclusions: MicroRNAs seem to be promising prognostic markers for diagnosis of endothelial dysfunction, non-alcoholic fatty liver disease, type 2 diabetes, metabolic syndrome and insulin resistance in children.

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Section: Discussionmentioning

confidence: 99%

MicroRNAs as the promising markers of comorbidities in childhood obesity—A systematic review

et al. 2021

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“…AMPK activity also exerts anti-inflammatory properties and maintains cellular redox balance. Moreover, AMPK also increases inhibitory phosphorylation of glycogen synthase kinase 3 beta (GSK3β), which contributes to mitochondrial protection against iron-induced oxidant stress [97,98].…”

Section: Ampk Activity Opposes the Warburg Effectmentioning

confidence: 99%

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

Uprety

Abrahamse

2022

Cells

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Despite some significant advancements, breast cancer has become the most prevalent cancer in the world. One of the main reasons for failure in treatment and metastasis has been attributed to the presence of cancer initiating cells—cancer stem cells. Consequently, research is now being focussed on targeting cancer cells along with their stem cell population. Non-oncology drugs are gaining increasing attention for their potent anticancer activities. Metformin, a drug commonly used to treat type 2 diabetes, is the best example in this regard. It exerts its therapeutic action by activating 5′ adenosine monophosphate-activated protein kinase (AMPK). Activated AMPK subsequently phosphorylates and targets several cellular pathways involved in cell growth and proliferation and the maintenance of stem-like properties of cancer stem cells. Therefore, AMPK is emerging as a target of choice for developing effective anticancer drugs. Vanadium compounds are well-known PTP inhibitors and AMPK activators. They find extensive applications in treatment of diabetes and obesity via PTP1B inhibition and AMPK-mediated inhibition of adipogenesis. However, their role in targeting cancer stem cells has not been explored yet. This review is an attempt to establish the applications of insulin mimetic vanadium compounds for the treatment of breast cancer by AMPK activation and PTP1B inhibition pathways.

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“…"3 triterpenes, 18b-GC, 18a-GC and 18b-glycyrrhetinic acid (18b-GA), and 13 flavonoids, licochalcone A (LCA), licochalcone B (LCB), licochalcone C (LCC), licochalcone D (LCD), licochal-cone E (LCE), isoliquiritigenin (ISL), echinatin (EC), glabridin (GLD), isoangustone A (ISOA), licoricidin (LID), licorisoflavan A (LIA), dehydroglyasperin C (DGC) as well as dehydroglyas-perin D (DGD), all have been reported to possess anti-inflammatory activity." [356]; contained in root twigs Anti-inflammation [278,360,386] Thymol: 1.71% in oil, 5.08% and 3.77% in fractions at 140C and undistilled oil, respectively [453] Anti-inflammation [275,319,337,389] Anti-viral [408] Paper mulberry (Broussonetia papyrifera) Anti-viral: [411] Kazinol J (CID: 21637732) Anti-inflammation: [320] Anti-viral: [420]…”

Section: Luteolinmentioning

confidence: 99%

Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia

Koyama

Kondo

Ueha

et al. 2021

IJMS

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The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms of the SARS-CoV-2 disease, COVID-19, is the loss of chemical senses, i.e., smell and taste. Smell training is one of the methods used in facilitating recovery of the olfactory sense, and it uses essential oils of lemon, rose, clove, and eucalyptus. These essential oils were not selected based on their chemical constituents. Although scientific studies have shown that they improve recovery, there may be better combinations for facilitating recovery. Many phytochemicals have bioactive properties with anti-inflammatory and anti-viral effects. In this review, we describe the chemical compounds with anti- inflammatory and anti-viral effects, and we list the plants that contain these chemical compounds. We expand the review from terpenes to the less volatile flavonoids in order to propose a combination of essential oils and diets that can be used to develop a new taste training method, as there has been no taste training so far. Finally, we discuss the possible use of these in clinical settings.

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Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation

Cited by 16 publications

References 31 publications

MicroRNAs as the promising markers of comorbidities in childhood obesity—A systematic review

MicroRNAs as the promising markers of comorbidities in childhood obesity—A systematic review

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia

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