Let A ∈ B(X), B ∈ B(Y ) and C ∈ B(Y, X) where X and Y are infinite Banach or Hilbert spaces. Let M C =A C 0 B be 2 × 2 upper triangular operator matrix acting on X ⊕ Y . In this paper, we consider some necessary and sufficient conditions for M C to be generalized Drazin-Riesz invertible. Furthermore, the set C∈B(Y,X) σ gDR (M C ) will be investigated and their relation between C∈B(Y,X) σ b (M C ) will be studied, where σ gDR (M C ) and σ b (M C ) denote the generalized Drazin-Riesz spectrum and the Browder spectrum, respectively.2010 Mathematics Subject Classification. 47A10, 47A53.