Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of <sup>18</sup>F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Terada, Eriko; Ashida, Kenji; Ohe, Kenji; Sakamoto, Shohei; Hasuzawa, Nao; Nomura, Masatoshi

doi:10.1002/ccr3.2259

Cited by 4 publications

(3 citation statements)

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“…In line with the reversible nature of BAT whitening in mice [39], intermittent cold exposure of adult humans increases cold‐induced BAT activity [62–64]. Given the substantial browning capacity of human adipocytes in vitro (Figs 2 and 4) and the evidence that dormant brown and brite adipocytes appear to be recruitable by thermogenic stimulation throughout the human body [42,44,65,66], achieving meaningful improvements in patient health through thermogenic activation appears to be a realistic and viable opportunity.…”

Section: The Phenotypic Versatility Of Mammalian Adipose Tissuementioning

confidence: 99%

“…Browning of WAT in humans in vivo has been observed in different anatomical locations as a secondary effect of pathophysiological conditions (such as paraganglioma, pheochromocytoma, burn injury, and cancer-associated cachexia), but also in response to change of season and repeated localized cold exposure [42][43][44][45][46][47][48][49][50]. Brite adipocytes are, however, largely absent in the WAT of most adult humans under normal conditions, possibly due to living in thermoneutral conditions.…”

Section: Adipocyte Transdifferentiation In the Human Adipose Organmentioning

confidence: 99%

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The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans

2020

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Brown and brite adipocytes contribute to energy expenditure through nonshivering thermogenesis. Though these cell types are thought to arise primarily from the de novo differentiation of precursor cells, their abundance is also controlled through the transdifferentiation of mature white adipocytes. Here, we review recent advances in our understanding of the regulation of white-tobrown transdifferentiation, as well as the conversion of brown and brite adipocytes to dormant, white-like fat cells. Converting mature white adipocytes into brite cells or reactivating dormant brown and brite adipocytes has emerged as a strategy to ameliorate human metabolic disorders. We analyze the evidence of learning from mice and how they translate to humans to ultimately scrutinize the relevance of this concept. Moreover, we estimate that converting a small percentage of existing white fat mass in obese subjects into active brite adipocytes could be sufficient to achieve meaningful benefits in metabolism. In conclusion, novel browning agents have to be identified before adipocyte transdifferentiation can be realized as a safe and efficacious therapy.

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Section: The Phenotypic Versatility Of Mammalian Adipose Tissuementioning

confidence: 99%

Section: Adipocyte Transdifferentiation In the Human Adipose Organmentioning

confidence: 99%

The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans

2020

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“… 18 , 19 The key similarities and differences between brown and beige adipocytes are summarised in Table 1 . It has been reported that WAT can be converted into beige adipose tissue, 8 , 20 which could represent an additional approach for treating obesity.…”

Section: Brown Adipose Tissue (Bat)mentioning

confidence: 99%

Brown adipose tissue and regulation of human body weight

Harb

Kheder

Poopalasingam

et al. 2022

Diabetes Metabolism Res

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Background Approximately 30% of the global population is affected by obesity. Traditional non‐surgical measures for weight loss have limited efficacy and tolerability. Therefore, there is a need for novel, effective therapies. Brown adipose tissue (BAT) has been implicated in physiological energy expenditure, indicating that it could be targeted to achieve weight loss in humans. The use of 18F‐fluorodeoxyglucose (18F‐FDG) positron emission tomography—computed tomography—(PET‐CT) imaging has enabled the discovery of functionally active BAT in the supraclavicular, subclavian, and thoracic spine regions of human adults. This review aims to discuss the reasons behind the renewed interest in BAT, assess whether it is metabolically important in humans, and evaluate its feasibility as a therapeutic target for treating obesity. Sources of material PubMed Central, Europe PMC, Medline. Findings In vivo studies have shown that BAT activity is regulated by thyroid hormones and the sympathetic nervous system. Furthermore, BAT uniquely contains uncoupling protein 1 (UCP1) that is largely responsible for non‐shivering thermogenesis. Cold exposure can increase BAT recruitment through the browning of white adipose tissue (WAT); however, this technique has practical limitations that may preclude its use. Currently available medicines for humans, such as the β3‐adrenergic receptor agonist mirabegron or the farnesoid X receptor agonist obeticholic acid, have generated excitement, although adverse effects are a concern. Capsinoids represent a tolerable alternative, which require further investigation. Conclusions The use of currently available BAT‐activating agents alone is unlikely to achieve significant weight loss in humans. A combination of BAT activation with physical exercise and modern, successful dietary strategies represents a more realistic option.

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Brown adipose tissue

Paulus

Bauwens

2023

Visceral and Ectopic Fat

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Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Cited by 4 publications

References 18 publications

The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans

The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans

Brown adipose tissue and regulation of human body weight

Brown adipose tissue

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Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of 18F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Cited by 4 publications

References 18 publications

The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans

The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans

Brown adipose tissue and regulation of human body weight

Brown adipose tissue

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Product

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Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report