Brown rice (Oryza sativa L. cv. Hiami) extract promotes cellular growth by upregulation of GH and IGF-1 expression and secretion

Abstract

The effects of the ethanolic extract of brown rice (BRE, L. cv. Hiami) on cellular growth were investigated. Gene expression analysis by qPCR showed that the expression of the mRNA expressions of growth hormone (GH) and insulin-like growth factor (IGF)-1 genes was significantly induced in cells stimulated with BRE compared with controls, and the effects were dose dependent. In addition, the hormone secretion of GH and IGF-1 was significantly induced in GH3 and HepG2 cells stimulated with BRE in line with the qPCR results. Collectively, these results suggest that BRE induces the expression and secretion of GH and IGF-1; therefore, application may promote cellular growth.