Brown tumors in nuclear medicine: a systematic review

Jacquet-Francillon, Nicolas; Prévôt, Nathalie

doi:10.1007/s12149-023-01832-1

Cited by 7 publications

(3 citation statements)

References 77 publications

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“…With parathyroidectomy and improvement of hyperparathyroidism, bone lesions tend to regress [ 9 – 12 ]. They can be found in any bone sites of the skeleton, being most commonly found in ribs, clavicles, spine, skull, and hip long bones [ 9 , 11 , 12 ]. However, atypical locations such as the sellar and parasellar region and sphenoid bone have been reported previously in one case [ 13 ], but without pituitary involvement.…”

Section: Discussionmentioning

confidence: 99%

Hypopituitarism due to a Large Osteoclastoma Arising from the Sphenoid Bone Invading the Pituitary Fossa in a Patient with Parathyroid Carcinoma

Bandeira,

Oliveira,

Lima

et al. 2023

Case Reports in Endocrinology

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Background. Parathyroid carcinoma accounts for <1% of cases of primary hyperparathyroidism (PHPT). This rare condition may present with severe hypercalcemia and bone complications such as osteoclastomas and pathologic fractures. Here, we present a rare condition of panhypopituitarism resulting from an osteoclastoma in the sphenoid bone that invaded the pituitary fossa due to parathyroid carcinoma. Case Report. A 47-year-old woman previously diagnosed with PHPT underwent a parathyroidectomy 6 years earlier, with histological examination indicating a parathyroid adenoma. After surgery, she continued to exhibit high serum parathyroid hormone (PTH) and calcium levels, with the development of bone pain and spontaneous fractures. Imaging exams showed a large osteoclastoma of the sphenoid bone, invading the pituitary fossa, causing hypopituitarism. A new parathyroidectomy was performed, with histological confirmation of parathyroid carcinoma and regression of the osteoclastoma. Conclusion. This case illustrates an unusual presentation of parathyroid carcinoma, in which an osteoclastoma of the sphenoid bone caused hypopituitarism.

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Section: Discussionmentioning

confidence: 99%

Hypopituitarism due to a Large Osteoclastoma Arising from the Sphenoid Bone Invading the Pituitary Fossa in a Patient with Parathyroid Carcinoma

Bandeira,

Oliveira,

Lima

et al. 2023

Case Reports in Endocrinology

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“…Most brown tumors grow slowly, usually in long bones, and typically provoke symptoms when local compression or pathological fractures occur. 1,2 Only few literatures have reported high uptake of brown tumors on 68 Ga-DOTATATE PET/CT, suggesting that they may overexpress somatostatin receptors. 3,4 Our case illustrates that brown tumor can also show high activity on 99m Tc-HYNIC-TOC scintigraphy.…”

Section: Figurementioning

confidence: 99%

“…Four months after the surgery, his bone pain and asthenia did not relieve. Most brown tumors grow slowly, usually in long bones, and typically provoke symptoms when local compression or pathological fractures occur 1,2 . Only few literatures have reported high uptake of brown tumors on 68 Ga-DOTATATE PET/CT, suggesting that they may overexpress somatostatin receptors 3,4 .…”

mentioning

confidence: 99%

Increased Uptake of Brown Tumor in 99mTc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia

Zhang,

Wang,

Liu

et al. 2023

Clin Nucl Med

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A 61-year-old man underwent a resection of tumor in the left tibia that caused osteomalacia 11 years ago. Postoperative bone pain and fatigue symptoms were briefly relieved but then recurred. To identify potential recurrent tumors, 99mTc-HYNIC-TOC scintigraphy was performed. Images revealed an osteolytic lesion in the right tibia with increased uptake. The lesion was subsequently resected, which pathologically proved a brown tumor. Symptoms of bone pain and weakness caused by osteomalacia did not relieve 4 months after the operation. Here, we present a rare case of brown tumor with high activity on 99mTc-HYNIC-TOC SPECT/CT, mimicking a culprit tumor of osteomalacia.

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Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism

Gonnelli,

Briot,

Cormier

et al. 2023

Osteoporos Int

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Brown tumors in nuclear medicine: a systematic review

Cited by 7 publications

References 77 publications

Hypopituitarism due to a Large Osteoclastoma Arising from the Sphenoid Bone Invading the Pituitary Fossa in a Patient with Parathyroid Carcinoma

Hypopituitarism due to a Large Osteoclastoma Arising from the Sphenoid Bone Invading the Pituitary Fossa in a Patient with Parathyroid Carcinoma

Increased Uptake of Brown Tumor in 99mTc-HYNIC-TOC Scintigraphy Mimicking Postoperative Recurrence of Tumor-Induced Osteomalacia

Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism

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