Brucelld canis: An Infectious Cause of Prolonged Fever of Undetermined Origin

Human Brucella canis Infection and Subsequent Laboratory Exposures Associated with a Puppy, New York City, 2012

“…As was the case with this child, the clinical presentation of human B. canis infection includes non‐specific symptoms (Rumley and Chapman, ; CDC, ). Human B. canis infection is typically milder than infections with other Brucella species; however, serious infections have been described and there is interest in determining whether some culture‐negative cases of endocarditis, osteomyelitis and septic arthritis may be caused by B. canis (Ying et al., ; Pappas et al., ).…”

The first case of Brucella canis in Sweden: background, case report and recommendations from a northern European perspective

“…The clinical presentation is unspecific, including fever (as opposed to the disease in dogs), headache and fatigue, and a history of exposure to dogs is usually needed to raise suspicion of infection with B. canis [68]. The infection may be underdiagnosed due to its rather unspecific symptoms.…”

“…Positive blood cultures confirm the diagnosis, but as the patients have been treated with antibiotics in many cases, the risk of a false negative culture is increased [69]. Furthermore, B. canis is slow-growing and mildly fastidious, producing low-grade bacteremias, decreasing cultural sensitivity [68]. Serodiagnosis is problematic due to a lack of antigenic cross-reactivity with the antigens routinely used, and a case that was serologically negative for B. canis despite positive blood culture has also been described [70].…”

<b>Diagnóstico molecular comparativo da brucelose canina pela aplicação das técnicas de reação em cadeia pela polimerase (PCR) e amplificação isotérmica do DNA mediada por <i>loop</i> (LAMP)</b>

“…No Brasil, a ocorrência da brucelose canina foi mensurada através de estudos soroepidemiológicos, microbiológicos e moleculares em diversas localidades do país e de acordo com os dados obtidos a frequência da B. canis variou de 0,3% a 54,77%, conforme verificado no quadro 1 (CARVALHO et al, 2000;AZEVEDO et al, 2003;ALMEIDA et al, 2004;KEID et al, 2004;AGUIAR et al, 2005;CAVALCANTI et al, 2006;FERREIRA, et al, 2007;MALEK dos REIS et al, 2008;VASCONCELOS et al, 2008;DORNELES et al, 2011;FERNANDES et al, 2011;SILVA et al, 2012;DREER et al, 2013;FERNANDES et al, 2013;MACHADO et al, 2013;SANTANA et al, 2013;PAZ et al, 2015;MASCOLLI et al, 2016). SANFORD, 1975;MUNDFORD et al, 1975;ROXO et al, 1990;AZEVEDO et al, 2003;LUCERO et al, 2005b;CORBEL et al, 2006;DENTINGER et al, 2012;KRUEGER et al, 2014 POLT et al, 1982;TOSI;NELSON, 1982;RUMLEY;CHAPMAN, 1986;ROXO et al, 1990;YING;NGUYEN;JAHRE, 1999;PIAMPIANO et al, 2000;SOLOAGA et al, 2004;WALLACH et al, 2004;LUCERO et al, 2005a;LUCERO et al,...…”