Brucellosis: An occupational hazard for medical laboratory personnel. Report of five cases

Grüner, Eva; Bernasconi, Enos; Galeazzi, Renato L.; Buhl, Daniela; Heinzle, Reinhilde; Nadal, Deborah

doi:10.1007/bf01780762

Cited by 30 publications

(21 citation statements)

References 9 publications

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“…More than 48 exposure incidents were described. Four reports described secondary exposures involving the same or related isolates (12,(25)(26)(27).…”

Section: Resultsmentioning

confidence: 99%

“…In 5 reports describing 86 exposures, the index cases were immigrants from (27)(28)(29) or travelers to (14,30) a country where the organism is endemic. The index cases in two reports describing eight exposures had consumed unpasteurized dairy products in a country where the organism is endemic (26) or imported the products to the United States (25). Time to bacterial growth was reported for six cases, with a median of 4 days (range 3 to 7).…”

Section: Resultsmentioning

confidence: 99%

“…Some workers experienced more severe signs, including soft tissue abscesses (some of which involved implants or prostheses) (35,37), spondylitis or sacroiliitis (26,33,35), and neurologic brucellosis (45). Chronic fatigue (34) and permanent hearing loss (46) were also reported.…”

Section: Resultsmentioning

confidence: 99%

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A Literature Review of Laboratory-Acquired Brucellosis

et al. 2013

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bBrucellosis is a bacterial zoonotic disease which has been associated with laboratory-acquired infections. No recent reviews have addressed the characteristics of laboratory-acquired brucellosis (LAB). English-language literature was reviewed to identify reports of laboratory exposures to Brucella spp. and LAB cases between 1982 and 2007. Evaluation of 28 case reports identified 167 potentially exposed laboratory workers, of whom 71 had LAB. Nine reports were identified that summarized an additional 186 cases of LAB. Only 18 (11%) exposures were due to laboratory accidents, 147 (88%) exposures were due to aerosolization of organisms during routine identification activities, and the circumstances of 2 (1%) exposures were unknown. Brucella melitensis was the causative agent in 80% (135/167) of the exposures. Workers with high-risk exposures were 9.3 times more likely to develop LAB than workers with low-risk exposures (95% confidence interval [CI], 3.0 to 38.6; P < 0.0001); they were also 0.009 times likelier to develop LAB if they took antimicrobial PEP than if they did not (95% CI, 0 to 0.042; P < 0.0001). The median incubation period in case and summary reports was 8 weeks (range 1 to 40 weeks). Antimicrobial PEP is effective in preventing LAB. The incubation period may be used to identify appropriate serological and symptom surveillance time frames for exposed laboratory workers.

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“…More than 48 exposure incidents were described. Four reports described secondary exposures involving the same or related isolates (12,(25)(26)(27).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A Literature Review of Laboratory-Acquired Brucellosis

et al. 2013

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“…Transmission of the bacteria to human beings occurs through cuts on the skin and direct contact with tissues from contaminated animals 2 . The second category of occupational brucellosis includes those infections acquired in clinical and research laboratories, with microbiologists and laboratory staff members in the corresponding risk group 1,3,6 . Laboratory-acquired infections represent 2% of all brucellosis cases worldwide 3 .…”

Section: Introductionmentioning

confidence: 99%

“…The attack rate after laboratory exposure ranges from 30% to 100% 3 . Most Brucella laboratory infections are caused by B. melitensis 6,9 .…”

Section: Introductionmentioning

confidence: 99%

Outbreak of laboratory-acquired Brucella abortus in Brazil: a case report

Rodrigues

Silva

Pinto

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):791-794, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0160-2013 INTRODUCTION ABSTRACTHuman brucellosis is an occupational disease affecting workers in slaughterhouses, butcher shops and the milk and dairy product industry as well as individuals who work in clinical or research laboratories. We report the fi rst outbreak of a Brucella abortus infection in a Brazilian laboratory and compare the data obtained with reports available in the literature. Exposure was a result of damage to a biological safety cabinet and failure of the unidirectional airfl ow ventilation system. An epidemiological investigation identifi ed 3 seroconverted individuals, 1 of whom had clinical manifestations and laboratory results compatible with infection at the time of exposure (n=11; attack rate=9.1%).

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Brucellosis

Young¹

2009

Bacterial Infections of Humans

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Brucellosis: An occupational hazard for medical laboratory personnel. Report of five cases

Cited by 30 publications

References 9 publications

A Literature Review of Laboratory-Acquired Brucellosis

A Literature Review of Laboratory-Acquired Brucellosis

Outbreak of laboratory-acquired Brucella abortus in Brazil: a case report

Brucellosis

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