Brucellosis in children: clinical observations in 115 cases

Shaalan, Mohamed; Memish, Ziad A.; Mahmoud, S.Al; Alomari, Ali; Khan, Mohammed Y.; Almuneef, Maha; Al-Alola, Suleiman A.

doi:10.1016/s1201-9712(02)90108-6

Cited by 140 publications

(167 citation statements)

References 18 publications

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“…Therefore, these circumstances place the nomads at increased risk of exposure to infected goats and related dairy products. Similar results were reported by other investigators (3,(17)(18)(19). We believe that slaughtering of infected animals is not the sole independent risk factor for brucellosis in Khuzestan (17).…”

Section: Discussionsupporting

confidence: 91%

“…Transmission of brucellosis in rural households is widespread, where close contact between human and domestic animals is high. Brucellosis is a prevalent disease in areas where B. mellitensis infection in animals is endemic and animals cohabit living quarters with people (18,19). Brucellosis in nomads and rural communities in the studied is likely to be transmitted by animals kept in homes, by the way of homemade dairy products that have not been treated or obtained from neighboring or village shops.…”

Section: Discussionmentioning

confidence: 99%

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Brucellosis Risk Factors in the Southwestern Province of Khuzestan, Iran

Alavi¹,

Mugahi²,

Nashibi³

et al. 2014

Int J Enteric Pathog

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Background: Brucellosis is an endemic infectious disease in Iran. Prevention strategies are based upon identification of risk factors for brucellosis. Objectives: The purpose of this study was to determine the principal risk factors for brucellosis in Khuzestan Province, Southwestern Iran. Patients and Methods: In this retrospective study, the medical records of 162 admitted patients, 81 brucellosis cases and 81 controls with other unrelated conditions, were reviewed. The study was undertaken in the Razi Hospital, Teheran, I.R. Iran, a university hospital where infected patients throughout Khuzestan are refereed. The diagnostic criteria of the disease were the Wright test and 2-Mercaptoethanol (2ME) agglutinin assay with titers greater than 1:160 and 1:80, respectively, and clinical symptoms compatible with brucellosis. Statistical analyses were performed with the SPSS 16.0 software. Univariate analysis was performed by calculating the odds ratio (OR) and the 95% confidence interval (CI) to compare cases and controls for each variable. Results: Of a total of 81 patients with brucellosis, 38 (46.8%) had had direct contact with animals, 47 (58%) had consumed high risk foods, and 48 (59.2%) were from rural areas. Analysis showed that brucellosis had a significant association with untreated milk consumption (OR 5.57, 95% CI = 1.77-17.08, P = 0.002), slaughtered meat (OR: 8.77, 95% CI = 1.07-71.81, P = 0.03), direct contact with animals and individuals who had a nomadic lifestyle (OR: 3.57, 95% CI = 1.34-9.54, P = 0.01). Conclusions: In the studied region, the main risk factors for brucellosis are: consumption of untreated milk/dairy products, slaughtered meat and direct contact with animals. Therefore, improved veterinary services and public health education are a requisite to control the disease.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Brucellosis Risk Factors in the Southwestern Province of Khuzestan, Iran

Alavi¹,

Mugahi²,

Nashibi³

et al. 2014

Int J Enteric Pathog

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“…Çalışmamızda %82.5 olguda çiğ süt ve süt ürünleriyle beslenme öyküsü bulunurken, hayvancılıkla uğraş öyküsüne %50.9 olguda rastlanmıştır. 115 olguluk bir seride ise %85 oranında çiğ sütle bulaş oranı saptanmıştır (6). 190 olguluk bir başka seride ise, hayvan ve çiğ süt ile bulaş oranı %91 bulunmuştur (7).…”

Section: Discussionunclassified

The Retrospective Evaluation Of 57 Cases With Brucellosis In Childhood

Helvacı¹,

Atila²,

Barışık³

2011

Tepecik Dergisi

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ÖZETAmaç: Kliniğimize 8 yıla yakın bir sürede başvuran 57 Brusellozlu çocuğun dosyasını geriye dönük incelemek. Gereç ve Yöntem: Bu çalışmada Tepecik Eğitim ve Araştırma Hastanesi Çocuk Findings:The mean age was 8.75±3.54 years and 63.2% of the patients were male. 82.5% of 57 cases had a history of consumption of unpasteurized milk and ingestion of contaminated dairy products, 50.9% of cases had a history contact with infected animal. Complication was found in 18 out of 57(31.6 percent) patient. Osteomyelitis, arthritis and menengitis was presented in 21.1%, 5.3% and 5.3% of the patients, respectively.

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“…Daha az sıklıkta eklem şişliği-ağrısı ve karın ağrısı ile karşılaşıldı. Literatürde en sık başvuru şikâyeti ateş olmasına rağmen (13,(18)(19)(20) bizim çalışmamızda en sık başvuru şikâyeti halsizlik (%100), kas ağrısı (% 100) ve kilo kaybı (% 86) idi. Bu neticeler hastaların belki de en çok rahatsız oldukları şikâyet ile hastaneye başvurmaları ile ilgili olabilir.…”

Section: Minimumunclassified

The evaluation of brucellosis in children in an endemic region of Turkey, Van

Sarı¹,

Sarı²,

Say³

et al. 2013

Gaziantep Med J

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ÖzetBruselloz özellikle ülkemizin doğu ve güneydoğu kesimlerinde endemik olarak görülen önemli bir enfeksiyon hastalığıdır. Bu makalede çocuklarda brusellozun klinik ve laboratuvar bulgularının ve tedavi sonuçlarının etkinliğini değerlendirmek amaçlandı.Eylül 2010 ile Şubat 2011 tarihleri arasında yaklaşık 6 aylık dönemde çocuk polikliniğine bruselloz düşündüren şikayetlerle başvuran çocuklar tetkik edildi. Tetkik edilen hastaların 43'üne bruselloz tanısı konuldu ve başvuru şikayetleri, fizik muayene bulguları ve laboratuvar sonuçları değerlendirildi. Olguların 22'si erkek (%51) olup ortalama yaşları 9.3 yaş (4 yaş-13 yaş) arasında idi. En sık başvuru yakınmaları; halsizlik olguların tamamı (%100), kas ağrısı olguların tamamı (%100) ve kilo kaybı (%86) idi. Olguların fizik muayenelerinde; artrit (%48), lenfadenopati (%6) ve splenomegali (%13) saptandı. Laboratuvar bulgularında olguların %51'inde sedimantasyon yüksekliği, %65'inde ALT/AST yüksekliği ve %72'sinde ise CRP pozitifliği vardı. Brusella aglütinasyon testleri olguların tamamında pozitifti. Kan kültüründe üreme olguların %6'sında tespit edildi. Olguların tamamına en az ikili antibiyotik tedavisi verildi. Rölaps %11 (n=5) oranında görüldü, mortalite gözlenmedi. Bruselloz özellikle hastalığın yaygın olduğu bölgelerde sağlık ekiplerinin üzerinde durması gereken ve koruyucu tedbirlerin alınması ve etkin tedavinin uygulanması gereken toplum sağlığı problemidir. Anahtar kelimeler: Bruselloz; çocuk; laboratuvar bulguları; tedavi. AbstractBrucellosis is an important infectious disease especially endemic in Eastern and Southeastern Turkey. In this study, we aimed to evaluate the clinical, laboratory and treatment results of Brucellosis in children. Children with nonspecific findings suggestive of Brucellosis were included from September 2010 to February 2011 from the outpatient clinic. The symptoms, physical findings and laboratory values are analyzed in 43 children who were diagnosed as Brucellosis.The mean age of children was 9.3 years (range: 4-13 years), 51%n:22) were male. Most common complaint was fatigue (100%), myalgia (100%) and weight loss (86%). Arthritis (48%), lymphadenopathy (6%), and splenomegaly (13%) has been identified. Laboratory values revealed high sedimentation rates (51%), high AST/ALT (65%), high CRP levels (72%). Brucella agglutination test was positive in all of the patients. Brucella was identified in 6% of blood cultures. All of the patients were treated with antibiotics of least two-drug combination. The relapse rate was 11% (n=5) and no mortality was observed. Brucellosis is an important health issue, especially in endemic regions, necessitating preventive measures and effective treatment.

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Brucellosis in children: clinical observations in 115 cases

Abstract: Brucellosis presents in various ways and should be included in the differential diagnosis of arthritis in endemic countries. Prevention should rely on education including on boiling raw milk.

Cited by 140 publications

References 18 publications

Brucellosis Risk Factors in the Southwestern Province of Khuzestan, Iran

Brucellosis Risk Factors in the Southwestern Province of Khuzestan, Iran

The Retrospective Evaluation Of 57 Cases With Brucellosis In Childhood

The evaluation of brucellosis in children in an endemic region of Turkey, Van

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