Brucellosis in Patients with Inflammatory Modic Changes: Results from Cross-sectional and Case–Control Comparisons

Delen, Veysel; Alpaycı, Mahmut

doi:10.1007/s42399-022-01319-6

Cited by 2 publications

(2 citation statements)

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“…However, grade 1 and grade 2 spondylolisthesis groups were similar to each other for the proportion of type 1 MCs. It is known that type 1 and type 2 MCs have interconvertible properties, and type 2 MCs has more stable structure (9,17). Therefore, the increased type 2 MCs seen in patients with grade 2 spondylolisthesis may be due to a conversion of type 1 and the stability of type 2 MCs.…”

Section: Discussionmentioning

confidence: 99%

“…The classification of MCs is based on the T1 and T2 weighted images (WI) of MRI sequences, and also the histopathological meanings (5). Although the exact etiopathogenesis underlying MCs is not fully understood, segmental instability, increased mechanical loading, and degenerative immune reaction following infections in the spine are suggested mechanisms (6)(7)(8)(9). There is no DOI: 10.37990/medr.1295316 consensus on the best effective treatment option for MCs, but it has been found that nonoperative therapy is useful for low back pain patients with MCs (10,11).…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between Spondylolisthesis and Modic Changes: An MRI Study

Yetişgin

Satış

et al. 2023

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Aim: We aimed to investigate the relationship between the presence of spondylolisthesis and its type with Modic changes by using lumbar magnetic resonance imaging (MRI). Methods: The study included 139 adult patients aged 18-65 years with lumbar spondylolisthesis detected on lumbar MRI. Demographic characteristics such as age, gender, and levels and degrees of spondylolisthesis and presence of lumbar Modic lesions/types were recorded. Results: A total of 75.7% of patients with stage 1 spondylolisthesis had Modic changes, while all patients with stage 2 spondylolisthesis had Modic changes (p=0.001). When only patients with Modic changes were examined, we found that the number of patients with stage 1 spondylolisthesis was higher than that of stage 2 (p0.05). Conclusion: We found that there was a relationship between lumbar spondylolisthesis type and presence of Modic changes. In the future, studies involving multicenter and high number of MRI examinations, this issue and the factors that may be effective can be examined in more details.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Relationship between Spondylolisthesis and Modic Changes: An MRI Study

Yetişgin

Satış

et al. 2023

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Can Hematological Inflammatory Indices Be Used to Differentiate Modic Type 1 Changes from Brucella Spondylodiscitis?

Şah,

Baran

2024

Medicina

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Background and Objectives: Differentiation between brucella spondylodiscitis and Modic type I changes (MC1) includes difficulties. Hematological inflammatory indices (HII) such as neutrophil to lymphocyte ratio (NLR) and aggregate index of systemic inflammation (AISI) are suggested as indicators of inflammation and infection and have diagnostic, prognostic, and predictive roles in various diseases. This study aimed to evaluate differences between brucella spondylodiscitis and MC1 in terms of HII. Materials and Methods: Thirty-five patients with brucella spondylodiscitis and thirty-seven with MC1 were enrolled in the study. Brucella spondylodiscitis and MC1 were diagnosed by microbiological, serological, and radiological diagnostic tools. HII (NLR, MLR, PLR, NLPR, SII, SIRI, AISI) were derived from baseline complete blood count. Results: The two groups were similar for age (p = 0.579) and gender (p = 0.092), leukocyte (p = 0.127), neutrophil (p = 0.366), lymphocyte (p = 0.090), and monocyte (p = 0.756) scores. The Brucella spondylodiscitis group had significantly lower pain duration (p < 0.001), higher CRP and ESR levels (p < 0.001), and lower platelet count (p = 0.047) than the MC1 group. The two groups had similarity in terms of HII: NLR (p = 0.553), MLR (p = 0.294), PLR (p = 0.772), NLPR (p = 0.115), SII (p = 0.798), SIRI (p = 0.447), and AISI (p = 0.248). Conclusions: Increased HII can be used to differentiate infectious and non-infectious conditions, but this may be invalid in brucellosis. However, pain duration, CRP and ESR levels, and platelet count may be useful to distinguish brucella spondylodiscitis from MC1.

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Brucellosis in Patients with Inflammatory Modic Changes: Results from Cross-sectional and Case–Control Comparisons

Cited by 2 publications

References 21 publications

The Relationship between Spondylolisthesis and Modic Changes: An MRI Study

The Relationship between Spondylolisthesis and Modic Changes: An MRI Study

Can Hematological Inflammatory Indices Be Used to Differentiate Modic Type 1 Changes from Brucella Spondylodiscitis?

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