Brucellosis

Glynn, M. Kathleen; Lynn, Tracey V.

doi:10.2460/javma.233.6.900

Cited by 83 publications

(71 citation statements)

References 86 publications

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“…The finding of a relationship between pregnancy and Brucella antibody in Australian fur seals is not consistent with findings in many terrestrial species in which antibody-positive individuals have a higher rate of infertility (Glynn and Lynn, 2008;Rhyan et al, 2009;Neta et al 2010). Infertility in terrestrial species is due to chronic infection with Brucella, and presence of antibody is positively correlated with the likelihood of isolating the pathogen (Roffe et al, 1999).…”

Section: Discussionmentioning

confidence: 72%

“…Factors that influence antibody prevalence estimates include the duration of antibody following exposure, the ability of the bacteria to establish chronic infection, and the frequency of repeated exposures to the bacteria. In terrestrial animals, Brucella antibody duration in the absence of chronic infection or repeated exposure is 1-2 yr (Glynn and Lynn, 2008). Longitudinal data were only available from one individual in our study, and this adult female changed from antibody-positive to antibody-negative over 6 yr.…”

Section: Discussionmentioning

confidence: 97%

“…Routes of infection for Brucella spp. include inhalation, ingestion, and venereal transmission (Nicoletti, 1980;Glynn and Lynn, 2008). Timing of antibody status conversion in Australian fur seals might be explained by age at weaning in this species.…”

Section: Discussionmentioning

confidence: 99%

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Epizootiology of Brucella Infection in Australian Fur Seals

Lynch

Duignan

Taylor

et al. 2011

Journal of Wildlife Diseases

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ABSTRACT:Novel members of the bacterial genus Brucella have recently emerged as pathogens of various marine mammal species and as potential zoonotic agents. We investigated the epizootiology of Brucella infection in Australian fur seals (Arctocephalus pusillus doriferus) by establishing demographic and temporal variations in antibody prevalence, attempting isolation of the causative agent, and determining whether this potential pathogen is involved in frequent abortions observed in this pinniped species. Two competitive enzyme-linked immunosorbent assays (cELISAs), an indirect ELISA, and a fluorescence polarization assay (FPA) were used to test sera for Brucella antibodies. The FPA and cELISA proved suitable for use in this species. Significant differences in antibody prevalence were found between age classes of seals sampled between 2007 and 2009 at one colony. Pups sampled at this site (n5134) were negative for Brucella antibodies by all serologic tests but 17 of 45 (38%) of juveniles were antibody-positive. Antibody prevalence in adult females was significantly higher than in juveniles (P50.044). . Inflammatory lesions suggestive of infectious agents were found in 14 of 39 aborted Australian fur seal pups, but pathologic changes were not uniformly consistent for Brucella infection. Culture and PCR investigations on fetal tissues were negative for Brucella. Culture and PCR on selected fresh or frozen tissues from 36 juvenile and adult animals were also negative. We suspect that the prevalence of active infection with Brucella in Australian fur seals is low relative to antibody prevalence.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 97%

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Epizootiology of Brucella Infection in Australian Fur Seals

Lynch

Duignan

Taylor

et al. 2011

Journal of Wildlife Diseases

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“…The most likely source of infection in these herds is believed to be infected freeranging elk (Van Campen and Rhyan, 2010). Control of brucellosis among domestic animals in the United States faces continued pressure from the presence of brucellosis in US wildlife and also in domestic livestock (especially cattle and goats) across the southern border in Mexico where eradication programs of bovine brucellosis (B. abortus infection) have made substantial progress whereas control of brucellosis among domestic goat herds (B. melitensis infection) has proven more challenging (Glynn and Lynn, 2008). …”

Section: Control Of Brucellosismentioning

confidence: 99%

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

Godfroid

Scholz²,

Barbier

et al. 2011

Preventive Veterinary Medicine

350

312

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“…Infection in humans occurs through direct contact with infected animals and from ingestion of contaminated dairy products (Glynn and Lynn 2008). Furthermore, there are no human vaccines currently available (Gorvel 2008).…”

Section: Introductionmentioning

confidence: 99%

A DNA vaccine encoding p39 and sp41 of Brucella melitensis induces protective immunity in BALB/c mice

2014

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ResuMeNLas especies de Brucella son bacterias gram-negativas intracelulares facultativas que pueden multiplicarse dentro células fagocíticas y no-fagocíticas en hospederos finales tanto humanos como animales. B. melitensis causa aborto en animales y fiebre ondulante en humanos. Una proteína de superficie de 41 kDa (sp41) está asociado con la adherencia bacteriana e invasión de células HeLa. El rol de esta proteína es importante para la interacción con células hospederas. Previamente se ha descrito el antígeno inmunodominante p39, medido por células T. Ambos vectores (pCIsp41 y pCIp39) indujeron la formación de inmunoglobulinas séricas antígeno-específicas así como una respuesta proliferativa de células T y una fuerte producción de interferon gamma luego de la re-estimulación, ya sea con los antígenos específicos o con extracto de Brucella. El nivel de protección fue significativo en ratones tratados con pCIp39 y pCIsp41, pero fue inferior al nivel requerido.Palabras claves: vacuna DNA, Brucella, proteina, protectiva. suMMARyBrucella species are facultative intracellular gram-negative bacteria that can multiply within phagocytic and non-phagocytic cells of humans or animals as end hosts. B. melitensis causes abortion in pregnant animals and undulant fever in humans. A 41 kDa surface protein (sp41) is associated with bacterial adherence and invasion of HeLa cells. The role of this protein a is important for the interaction with host cells. Previously, the putative periplasmic binding protein p39 had been described as T-cell immunodominant Brucella antigens. Both vectors (pCIp39 and pCIsp41) induced antigenspecific serum immunoglobulin as well as a T-cell-proliferative response and a strong gamma interferon production upon re-stimulation with either the specific antigens or Brucella extract. The level of protection was significant in pCIp39 and pCIsp41 treated mice but it was lower than the required level.

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Brucellosis

Cited by 83 publications

References 86 publications

Epizootiology of Brucella Infection in Australian Fur Seals

Epizootiology of Brucella Infection in Australian Fur Seals

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

A DNA vaccine encoding p39 and sp41 of Brucella melitensis induces protective immunity in BALB/c mice

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