Brucellosis seroprevalence in dairy cattle in China during 2008–2018: A systematic review and meta-analysis

Ran, Xuhua; Cheng, Jiajia; Wang, Miaomiao; Chen, Xiaohong; Wang, Haoxian; Yu, Gui; Ni, Hong-Bo; Zhang, Xiaoxuan; Wen, Xiaobo

doi:10.1016/j.actatropica.2018.10.002

Cited by 56 publications

(35 citation statements)

References 33 publications

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“…This reminded us that though there was a possibility that the development of husbandry created a more suitable environment for the epidemic of human brucellosis, some other factors might minimize or even counteract such a risk. However, it did not mean to deny the influence of husbandry development on human brucellosis, since human brucellosis is indeed a zoonosis, and the infection among humans always comes from infected animals [32]. By contrast, such a result emphasized that the risk created by the development of husbandry could be reduced if much attention could be paid to some protective factors of human brucellosis. Health impact One interesting point of this study was that health and hygiene condition was associated with human brucellosis epidemics.…”

Section: Discussionmentioning

confidence: 99%

An exploratory study of factors associated with human brucellosis in mainland China based on time-series-cross-section data from 2005 to 2016

Lin

Zhang

et al. 2019

PLoS ONE

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Objective Many studies focused on reasons behind the increasing incidence and the spread of human brucellosis in mainland China, yet most of them lacked comprehensive consideration with quantitative evidence. Hence, this study aimed to further investigate the epidemic mechanism and associated factors of human brucellosis so as to provide thoughts for future countermeasures in China and the rest of the world. Methods Data of human brucellosis incidence and some associated factors in economy, animal husbandry, transportation as well as health and hygiene were collected at provincial level from 2005–2016. Time series plots were first used to visualize the annual incidence and annual rate of change of human brucellosis for each province, then cluster analysis categorized all the 31 provinces of mainland China based on their incidence time series during the study period. In addition, according to the characteristics of data, the dynamic panel data model in combination with supervised principal component analysis was proposed to explore effects of associated factors on human brucellosis. Results 1. The incidence rate of human brucellosis in mainland China increased three-fold from 1.41 per 100,000 people in 2005 to 4.22 per 100,000 people in 2014, though it went down a little in 2015 and 2016. Incidence rates in the north have always been higher than those in the south, but the latter also experienced an upward trend especially between 2012 and 2016. 2. The 31 provinces of mainland China were categorized into three clusters, and each cluster had its own characteristics of incidence time series. 3. The impact of health and hygiene situations on the prevention and control work of human brucellosis was still very limited and trivial (regression coefficient = -0.02). Therefore, it was plausible to presume that improving the personal average number of medical institutes and the proportion of rural medical expenditure might be helpful in preventing and controlling human brucellosis. Conclusions The epidemic status of human brucellosis has changed in both spatial and temporal dimensions in recent years in mainland China. Apart from traditional control measures, more attention should be paid to the improvement of medical healthcare especially in rural areas in the hope of enhancing the control effect.

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Section: Discussionmentioning

confidence: 99%

An exploratory study of factors associated with human brucellosis in mainland China based on time-series-cross-section data from 2005 to 2016

Lin

Zhang

et al. 2019

PLoS ONE

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“…B. melitensis is the predominant circulating strain in northeastern and northwestern China and it produces the most severe infections in humans [5]. B. abortus is the main etiological agent of brucellosis in cattle, but it is associated with far fewer cases of human disease [6, 7]. Human cases due to B. abortus are sporadic in China and, in Sichuan, B. abortus is the predominant strain isolated.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the molecular characteristics of Brucella isolates from Guangxi Province, China

Liu

Wang²,

Zhao

et al. 2019

BMC Microbiol

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BackgroundHuman brucellosis has become a severe public health problem in China’s Guangxi Province, and there has been higher prevalence of brucellosis in this region after 2010. Both multiple locus variable-number tandem repeat analysis (MLVA) and multilocus sequence typing (MLST) assay schedules were used to genotype isolates and determine relationships among isolates.ResultsA total of 40 isolates of Brucella were obtained from humans, pigs, and dogs from 1961 to 2016. There were at least three species of Brucella detected in Guangxi Province, Brucella melitensis, Brucella suis, and Brucella canis, with 16, 17, and 7 isolates, respectively. Of which B. suis biovar 3 was the predominant species resulting in pig brucellosis in the area examined before 2000s. Moreover, B. melitensis biovar 3 was found to be mainly responsible for human brucellosis during 2012–2016. All B. melitensis isolates in this study belonged to East Mediterranean lineage. MLVA-11 genotype 116 was the dominant genotype and represented 81.2% of the isolates. MLVA cluster analysis showed there to be 44% (7/16) brucellosis cases caused by B. melitensis with a profile of outbreak epidemic from 2012 to 2016. However, nearly 83.3% (20/24) of brucellosis cases resulting from both B. suis and B. canis showed no epidemiological links or sporadic characteristics. MLVA-16 analysis confirmed extensive genotype-sharing events between B. melitensis isolates from Guangxi and other northern provinces within China. These data revealed that there are potential epidemiology links among these strains. B. suis strains of this study showed a unique genetic lineage at the global level and may have existed historically in this area. However, present B. canis isolates were closely related to previously reported isolates in Korea, where they may have originated. MLST typing showed that the population structure of Brucella strains had changed considerably in this province; ST17 and ST21, two previously predominant populations appeared to have been replaced by recently emerging ST8 group.ConclusionsOur investigation data have inspired the hypothesis that Guangxi Province had been subject to an imported human brucellosis epidemic. Our data suggest that strains found in Northern regions of China are the principal source of infections in recent cases of human brucellosis in Guangxi Province. Comparative genomic analysis from more strains is necessary to confirm this hypothesis. This work will facilitate better understanding of the epidemiology and improve the effectiveness of control and prevention of brucellosis in this region.

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“…Recently, a study on the epidemiology of human brucellosis was carried out with official data ( 6 ). Moreover, Ran and his group applied a meta-analysis on seroprevalence in dairy cows in China ( 22 ). Despite these interesting and novel studies, information on the dominant biotype of Brucella in multiple kinds of hosts and prevalence within other animals is ambiguous.…”

Section: Discussionmentioning

confidence: 99%

ONE Health Approach to Address Zoonotic Brucellosis: A Spatiotemporal Associations Study Between Animals and Humans

Zhou

Pan

et al. 2020

Front. Vet. Sci.

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Background: Brucellosis is one of the most significant zoonosis over the world, threatening both veterinary and human public health. However, few studies were focused on nationwide animal brucellosis and made association with human brucellosis. Methodology and Principal Findings: We conducted a bilingual literature search on Brucella or brucellosis in China on the two largest databases (China National Knowledge Infrastructure and PubMed) and conducted a systematic review. A total of 1,383 Chinese and 81 English publications, published between 1958 and 2018 were identified. From them, 357 publications presenting 692 datasets were subjected to the meta-analysis. The overall prevalence rate is 1.70% (95% CI: 1.66–1.74), with a declining (until the late 1990s) and rising trend (starting the early 2000s). Interestingly, the animal with highest prevalence rate is canine (8.35%, 95% CI: 7.21–9.50), and lowest in cattle (1.22%, 95% CI: 1.17–1.28). The prevalence of Brucella in animals was unequally distributed among the 24 examined regions in China. Conclusions: Brucellosis is a reemerging disease for both humans and animals in China. The observed data suggests that dogs and yaks are the leading reservoirs for Brucella , and the provinces with highest prevalence rates in animals are Hubei, Sichuan, Inner Mongolia, Fujian, and Guizhou. Accordingly targeted intervention policy should be implemented to break the Brucella transmission chain between animals and humans in China.

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Brucellosis seroprevalence in dairy cattle in China during 2008–2018: A systematic review and meta-analysis

Cited by 56 publications

References 33 publications

An exploratory study of factors associated with human brucellosis in mainland China based on time-series-cross-section data from 2005 to 2016

An exploratory study of factors associated with human brucellosis in mainland China based on time-series-cross-section data from 2005 to 2016

Investigation of the molecular characteristics of Brucella isolates from Guangxi Province, China

ONE Health Approach to Address Zoonotic Brucellosis: A Spatiotemporal Associations Study Between Animals and Humans

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