Brucellosis with p-ANCA-associated renal failure, leukocytoclastic vasculitis and endocarditis: Case report

Abstract

The relationship between brucellosis and p-antinuclear cytoplasmic antibody (p-ANCA)-associated vasculitis (pAAV) is a rare condition. Herein, we report a 52-year-old man who was diagnosed as rapidly progressive glomerulonephritis (RPGN) and endocarditis due to brucellosis. He was treated with antimicrobial agents, steroids, plasmapheresis, renal replacement therapy and aortic valve replacement. According to our best of knowledge, no similar case has been reported previously in the literature in regard to p-ANCA anti-lactoferrin antibodies associated-glomerulonephritis with brucellosis and endocarditis.

Kidney Disease in Brucellosis

“…Vasculitis is a lethal picture of brucellosis with systemic organ involvement. Turgay et al [7] reported 52-year-old male with Brucella infection and ANCAassociated vasculitis that induced rapidly progressive glomerulitis. The patient had endocarditis with vegetation on the aortic valve and leukocytoclastic vasculitis.…”