Bruch's membrane opening – minimum rim width measurement after acute primary angle-closure

Abstract

Purpose To evaluate Bruch's membrane opening – minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) following an acute primary angle-closure attack (APAC). Materials and methods Nine consecutive patients with unilateral APAC were included. Patients with a bilateral attack, with signs of glaucomatous optic nerve damage or evidence of a previous APAC in either eye were excluded. Three months after the attack, all eyes underwent BMO-MRW and RNFLT measurements with SDOCT. APAC eyes were compared to the contralateral eyes. Results Three months after the attack, mean BMO-MRWs were 281.22 ± 56.88 μm and 313.78 ± 43.48 μm ( P = 0.009) and mean RNFLTs were 78 ± 15.36 μm vs 95.78 ± 10.81 μm ( P = 0.008) in the APAC and contralateral eyes, respectively. RNFLT and BMO-MRW measurements had a strong positive correlation ( R = 0.7436, P = 0.013). APAC eyes had a shorter axial length (21.85 ± 1.21 vs 22 ± 1.07, P = 0.042) and shallower anterior chamber depth (2.29 ± 0.21 vs 2.41 ± 0.12, P = 0.039) than contralateral eyes. IOP at presentation showed a strong negative correlation with both BMO-MRW ( R = −0.7669, P = 0.009) and RNFLT measurements ( R = −0.7723, P = 0.008). Conclusion BMO-MRW and RNFLT measurements are significantly reduced 3 months after an APAC when compared to the contralateral eye. IOP at presentation may have an impact on the reduction of these parameters.

Effect of Conventional Cataract Surgery and Femtosecond Laser‐Assisted Cataract Surgery on Bruch’s Membrane Opening‐Minimum Rim Width, Retinal Nerve Fiber Layer, and Macular Thickness

“…This may be related with the findings of a study by Chauhan et al [ 19 ], who stated that BMO-MRW may be more sensitive to ONH conformational changes that precede but do not directly correlate to RNFL loss. Some studies have shown that acute increases in IOP cause significant changes in BMO-MRW [ 50 , 51 ], and it has also been suggested that glaucoma subjects are more susceptible to these IOP increases compared to normal subjects [ 52 ]. In spite of the intraoperative IOP increases that occur during CCS and FLACS, in the present study, there was not a decrease in BMO-MRW following cataract surgery.…”